A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development S Robinson, JL Delongeas, E Donald, D Dreher, M Festag, S Kervyn, ... Regulatory Toxicology and Pharmacology 50 (3), 345-352, 2008 | 105 | 2008 |
An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. I: Establishment of the differentiation
M Festag, C Sehner, P Steinberg, B Viertel Toxicology in Vitro 21 (8), 1619-1630, 2007 | 89 | 2007 |
A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies K Chapman, F Sewell, L Allais, JL Delongeas, E Donald, M Festag, ... Regulatory Toxicology and Pharmacology 67 (1), 27-38, 2013 | 57 | 2013 |
Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy F Bauss, M Lechmann, BF Krippendorff, R Staack, F Herting, M Festag, ... Molecular oncology 10 (8), 1317-1329, 2016 | 46 | 2016 |
Inhibition of EGF uptake by nephrotoxic antisense drugs in vitro and implications for preclinical safety profiling A Moisan, M Gubler, JD Zhang, Y Tessier, KD Erichsen, S Sewing, ... Molecular Therapy-Nucleic Acids 6, 89-105, 2017 | 28 | 2017 |
Pediatric safety of polysorbates in drug formulations C Kriegel, M Festag, RSK Kishore, D Roethlisberger, G Schmitt Children 7 (1), 1, 2020 | 27 | 2020 |
Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human
F Sewell, K Chapman, P Baldrick, D Brewster, A Broadmeadow, P Brown, ... Regulatory Toxicology and Pharmacology 70 (1), 413-429, 2014 | 26 | 2014 |
Assessment of the Genotoxic Potential of Azidothymidine in the Comet, Micronucleus, and Pig-a Assay M Guérard, J Koenig, M Festag, SD Dertinger, T Singer, G Schmitt, ... toxicological sciences 135 (2), 309-316, 2013 | 20 | 2013 |
Interspecies variation of outer retina and choriocapillaris imaged with optical coherence tomography P Soukup, P Maloca, B Altmann, M Festag, EA Atzpodien, S Pot Investigative ophthalmology & visual science 60 (10), 3332-3342, 2019 | 14 | 2019 |
From the cover: The minipig is a suitable Non-Rodent model in the safety assessment of single stranded oligonucleotides A Braendli-Baiocco, M Festag, K Dumong Erichsen, R Persson, ... Toxicological Sciences 157 (1), 112-128, 2017 | 12 | 2017 |
Vehicle systems and excipients used in minipig drug development studies ML Weaver, AB Grossi, J Schützsack, J Parish, J Løgsted, IB Bøgh, ... Toxicologic Pathology 44 (3), 367-372, 2016 | 11 | 2016 |
Assessment of preclinical liver and skeletal muscle biomarkers following clofibrate administration in Wistar rats P Maliver, M Festag, M Bennecke, F Christen, B Bánfai, B Lenz, M Winter Toxicologic pathology 45 (4), 506-525, 2017 | 8 | 2017 |
Safety, tissue distribution, and metabolism of LNA-containing antisense oligonucleotides in rats F Romero-Palomo, M Festag, B Lenz, S Schadt, A Brink, A Kipar, ... Toxicologic pathology 49 (6), 1174-1192, 2021 | 6 | 2021 |
Genotoxicity testing of peptides: folate deprivation as a marker of exaggerated pharmacology M Guérard, A Zeller, M Festag, C Schubert, T Singer, L Müller Toxicology and applied pharmacology 279 (3), 419-427, 2014 | 5 | 2014 |
Morphologic and functional effects of gamma secretase inhibition on splenic marginal zone B cells MC de Vera Mudry, F Regenass-Lechner, L Ozmen, B Altmann, M Festag, ... International journal of Alzheimers disease 2012, 2012 | 5 | 2012 |
Effect of 4-chlorobiphenyls as an initiator of rat liver carcinogenesis P Espandiari, TP Twaroski, M Festag, EY Lee, HP Glauert, LW Robertson PCBsRecent Advances in the Environmental Toxicology and Health Effects 399, 2001 | 5 | 2001 |
Emesis in minipigs and relevance in nonclinical safety testing. G. Schmitt, M. Festag, S. Roberts Göttingen Minipigs magazine 63, 6-9, 2022 | | 2022 |
Cardiovascular effects of RTR2996, a single stranded oligonucleotide, in the minipig S Roberts, A Greiter-Wilke, D Waiz, R Jenni, C Weile, M Zihlmann, ... Journal of Pharmacological and Toxicological Methods 99, 106595, 2019 | | 2019 |
Antisense oligonucleotidesrecent advances in preclinical safety assessment M Festag Toxicology Letters 295, S23, 2018 | | 2018 |
Preclinical assessment of a selective and potent γ-secretase inhibitor in a non-rodent species MCDV Mudry, M Festag, L Müller Toxicology Letters, S313, 2016 | | 2016 |