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john gardiner
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Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases
HS Toogood, JM Gardiner, NS Scrutton
ChemCatChem 2 (8), 892-914, 2010
3222010
CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane
S Barcelo, JM Gardiner, A Gescher, JK Chipman
Carcinogenesis 17 (2), 277-282, 1996
2761996
Asymmetric reduction of activated alkenes by pentaerythritol tetranitrate reductase: specificity and control of stereochemical outcome by reaction optimisation
A Fryszkowska, H Toogood, M Sakuma, JM Gardiner, GM Stephens, ...
Advanced synthesis & catalysis 351 (17), 2976-2990, 2009
1362009
Highly Enantioselective Reduction of β,β-Disubstituted Aromatic Nitroalkenes Catalyzed by Clostridium sporogenes
A Fryszkowska, K Fisher, JM Gardiner, GM Stephens
The Journal of organic chemistry 73 (11), 4295-4298, 2008
1172008
Structure‐based insight into the asymmetric bioreduction of the C C double bond of α, β‐unsaturated nitroalkenes by pentaerythritol tetranitrate reductase
HS Toogood, A Fryszkowska, V Hare, K Fisher, A Roujeinikova, D Leys, ...
Advanced synthesis & catalysis 350 (17), 2789-2803, 2008
1042008
Free energy landscapes of iduronic acid and related monosaccharides
BM Sattelle, SU Hansen, J Gardiner, A Almond
Journal of the American Chemical Society 132 (38), 13132-13134, 2010
1012010
An updated synthesis of the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate
GT Potter, GC Jayson, GJ Miller, JM Gardiner
The Journal of Organic Chemistry 81 (8), 3443-3446, 2016
992016
Making the longest sugars: a chemical synthesis of heparin-related [4] n oligosaccharides from 16-mer to 40-mer
SU Hansen, GJ Miller, MJ Cliff, GC Jayson, JM Gardiner
Chemical science 6 (11), 6158-6164, 2015
972015
Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor
C Ferreras, G Rushton, CL Cole, M Babur, BA Telfer, TH Van Kuppevelt, ...
Journal of Biological Chemistry 287 (43), 36132-36146, 2012
932012
Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli
HS Toogood, AN Cheallaigh, S Tait, DJ Mansell, A Jervis, A Lygidakis, ...
ACS Synthetic Biology 4 (10), 1112-1123, 2015
852015
A site‐saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity
HS Toogood, A Fryszkowska, M Hulley, M Sakuma, D Mansell, ...
ChemBioChem 12 (5), 738-749, 2011
792011
Acyclic nucleosides as antiviral compounds
S Freeman, JM Gardiner
Molecular biotechnology 5, 125-137, 1996
791996
Structure-activity relationships of anti-HIV-1 N-alkoxy-and N-allyloxy-benzimidazoles
TM Evans, JM Gardiner, N Mahmood, M Smis
Bioorganic & Medicinal Chemistry Letters 7 (4), 409-412, 1997
731997
Synthesis and HIV-1 inhibition of novel benzimidazole derivatives
JM Gardiner, CR Loyns, A Burke, A Khan, N Mahmood
Bioorganic & Medicinal Chemistry Letters 5 (12), 1251-1254, 1995
731995
The influence of few-layer graphene on the gas permeability of the high-free-volume polymer PIM-1
K Althumayri, WJ Harrison, Y Shin, JM Gardiner, C Casiraghi, PM Budd, ...
Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2016
722016
Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N-acetyl-1, 3, 4-oxadiazoles
RY Morjan, AM Mkadmh, I Beadham, AA Elmanama, MR Mattar, J Raftery, ...
Bioorganic & medicinal Chemistry letters 24 (24), 5796-5800, 2014
682014
Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site‐saturated libraries
ME Hulley, HS Toogood, A Fryszkowska, D Mansell, GM Stephens, ...
ChemBioChem 11 (17), 2433-2447, 2010
682010
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum
DJ Mansell, HS Toogood, J Waller, JMX Hughes, CW Levy, JM Gardiner, ...
ACS catalysis 3 (3), 370-379, 2013
672013
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase
V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ...
Acs Catalysis 7 (9), 6268-6282, 2017
662017
Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis
CL Cole, SU Hansen, M Barath, G Rushton, JM Gardiner, E Avizienyte, ...
PLoS One 5 (7), e11644, 2010
642010
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