| Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors YI Zhu, T Tchkonia, H Fuhrmann‐Stroissnigg, HM Dai, YY Ling, MB Stout, ... Aging cell 15 (3), 428-435, 2016 | 932 | 2016 |
| COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A CA Phillips-Krawczak, A Singla, P Starokadomskyy, Z Deng, DG Osborne, ... Molecular biology of the cell 26 (1), 91-103, 2015 | 211 | 2015 |
| Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate L Hu, M Chen, X Chen, C Zhao, Z Fang, H Wang, H Dai Cell death & disease 11 (4), 281, 2020 | 183 | 2020 |
| Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment C Correia, SH Lee, XW Meng, ND Vincelette, KLB Knorr, H Ding, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (7), 1658-1671, 2015 | 181 | 2015 |
| Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization H Dai, A Smith, XW Meng, PA Schneider, YP Pang, SH Kaufmann Journal of Cell Biology 194 (1), 39-48, 2011 | 178 | 2011 |
| BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma C Correia, PA Schneider, H Dai, A Dogan, MJ Maurer, AK Church, ... Blood, The Journal of the American Society of Hematology 125 (4), 658-667, 2015 | 159 | 2015 |
| Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization XW Meng, SH Lee, H Dai, D Loegering, C Yu, K Flatten, P Schneider, ... Journal of Biological Chemistry 282 (41), 29831-29846, 2007 | 135 | 2007 |
| Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance H Dai, H Ding, XW Meng, SH Lee, PA Schneider, SH Kaufmann Cancer research 73 (23), 6998-7008, 2013 | 113 | 2013 |
| Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells AJ Smith, H Dai, C Correia, R Takahashi, SH Lee, I Schmitz, ... Journal of Biological Chemistry 286 (20), 17682-17692, 2011 | 106 | 2011 |
| Prime, shock, and kill: priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size NW Cummins, AM Sainski, H Dai, S Natesampillai, YP Pang, GD Bren, ... Journal of virology 90 (8), 4032-4048, 2016 | 103 | 2016 |
| Evaluation of the BH3-only protein Puma as a direct Bak activator H Dai, YP Pang, M Ramirez-Alvarado, SH Kaufmann Journal of Biological Chemistry 289 (1), 89-99, 2014 | 97 | 2014 |
| BCL2 family, mitochondrial apoptosis, and beyond H Dai, W Meng, S Kaufmann Cancer Translational Medicine 2 (1), 2016 | 85 | 2016 |
| MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors KLB Knorr, PA Schneider, XW Meng, H Dai, BD Smith, AD Hess, JE Karp, ... Cell Death & Differentiation 22 (12), 2133-2142, 2015 | 83 | 2015 |
| CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak KN Kremer, KL Peterson, PA Schneider, XW Meng, H Dai, AD Hess, ... Journal of Biological Chemistry 288 (32), 22899-22914, 2013 | 76 | 2013 |
| Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4 H Sun, J Liu, J Zhang, W Shen, H Huang, C Xu, H Dai, J Wu, Y Shi Biochemical and biophysical research communications 358 (2), 435-441, 2007 | 71 | 2007 |
| Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis H Dai, XW Meng, SH Lee, PA Schneider, SH Kaufmann Journal of biological chemistry 284 (27), 18311-18322, 2009 | 60 | 2009 |
| Apoptotic stress causes mtDNA release during senescence and drives the SASP S Victorelli, H Salmonowicz, J Chapman, H Martini, MG Vizioli, JS Riley, ... Nature 622 (7983), 627-636, 2023 | 58 | 2023 |
| Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis S Rizvi, JC Mertens, SF Bronk, P Hirsova, H Dai, LR Roberts, ... Journal of Biological Chemistry 289 (33), 22835-22849, 2014 | 53 | 2014 |
| Bak conformational changes induced by ligand binding: insight into BH3 domain binding and Bak homo-oligomerization YP Pang, H Dai, A Smith, XW Meng, PA Schneider, SH Kaufmann Scientific reports 2 (1), 257, 2012 | 53 | 2012 |
| Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells H Dai, H Ding, XW Meng, KL Peterson, PA Schneider, JE Karp, ... Genes & development 29 (20), 2140-2152, 2015 | 52 | 2015 |
Scott KaufmannProfessor of Pharmacology and Medicine, Mayo Clinic College of MedicineVerified email at Mayo.edu
