Structural insight into the biogenesis of β-barrel membrane proteins N Noinaj, AJ Kuszak, JC Gumbart, P Lukacik, H Chang, NC Easley, ... Nature 501 (7467), 385-390, 2013 | 459 | 2013 |
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... Nature communications 11 (1), 5047, 2020 | 438 | 2020 |
Structure and function of human 17β-hydroxysteroid dehydrogenases P Lukacik, KL Kavanagh, U Oppermann Molecular and cellular endocrinology 248 (1-2), 61-71, 2006 | 239 | 2006 |
Autotransporter structure reveals intra-barrel cleavage followed by conformational changes TJ Barnard, N Dautin, P Lukacik, HD Bernstein, SK Buchanan Nature structural & molecular biology 14 (12), 1214-1220, 2007 | 203 | 2007 |
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell Stem Cell 29 (2), 217-231. e8, 2022 | 174 | 2022 |
Structural engineering of a phage lysin that targets Gram-negative pathogens P Lukacik, TJ Barnard, PW Keller, KS Chaturvedi, N Seddiki, JW Fairman, ... Proceedings of the National Academy of Sciences 109 (25), 9857-9862, 2012 | 172 | 2012 |
Complement regulation at the molecular level: the structure of decay-accelerating factor P Lukacik, P Roversi, J White, D Esser, GP Smith, J Billington, ... Proceedings of the National Academy of Sciences 101 (5), 1279-1284, 2004 | 148 | 2004 |
Structure of colicin I receptor bound to the R‐domain of colicin Ia: implications for protein import SK Buchanan, P Lukacik, S Grizot, R Ghirlando, MMU Ali, TJ Barnard, ... The EMBO journal 26 (10), 2594-2604, 2007 | 126 | 2007 |
Structural insights into Ail-mediated adhesion in Yersinia pestis S Yamashita, P Lukacik, TJ Barnard, N Noinaj, S Felek, TM Tsang, ... Structure 19 (11), 1672-1682, 2011 | 108 | 2011 |
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity P Lukacik, B Keller, G Bunkoczi, K Kavanagh, W Hwa Lee, J Adamski, ... Biochemical Journal 402 (3), 419-427, 2007 | 104 | 2007 |
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-β-hydroxybutyrate dehydrogenase K Guo, P Lukacik, E Papagrigoriou, M Meier, WH Lee, J Adamski, ... Journal of biological chemistry 281 (15), 10291-10297, 2006 | 84 | 2006 |
SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation X Wu, P Lukacik, KL Kavanagh, U Oppermann Molecular and cellular endocrinology 265, 71-76, 2007 | 71 | 2007 |
Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding HTH Chan, MA Moesser, RK Walters, TR Malla, RM Twidale, T John, ... Chemical science 12 (41), 13686-13703, 2021 | 64 | 2021 |
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor D Zaidman, P Gehrtz, M Filep, D Fearon, R Gabizon, A Douangamath, ... Cell chemical biology 28 (12), 1795-1806. e5, 2021 | 60 | 2021 |
Streptococcus pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor CD Owen, P Lukacik, JA Potter, O Sleator, GL Taylor, MA Walsh Journal of Biological Chemistry 290 (46), 27736-27748, 2015 | 58 | 2015 |
Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint P Roversi, L Marti, AT Caputo, DS Alonzi, JC Hill, KC Dent, A Kumar, ... Proceedings of the National Academy of Sciences 114 (32), 8544-8549, 2017 | 55 | 2017 |
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine … H Achdout, A Aimon, E Bar-David, GM Morris BioRxiv, 2020 | 53 | 2020 |
Biological activity, membrane‐targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli J White, P Lukacik, D Esser, M Steward, N Giddings, JR Bright, ... Protein science 13 (9), 2406-2415, 2004 | 49 | 2004 |
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors TR Malla, A Tumber, T John, L Brewitz, C Strain-Damerell, CD Owen, ... Chemical Communications 57 (12), 1430-1433, 2021 | 46 | 2021 |
Using a bacteriocin structure to engineer a phage lysin that targets Yersinia pestis P Lukacik, TJ Barnard, SK Buchanan Biochemical Society Transactions 40 (6), 1503-1506, 2012 | 46 | 2012 |