Stephen Douthwaite
Stephen Douthwaite
Professor of Molecular Microbiology, University of Southern Denmark
Patvirtintas el. paštas
Macrolide resistance conferred by base substitutions in 23S rRNA
B Vester, S Douthwaite
Antimicrobial agents and chemotherapy 45 (1), 1-12, 2001
The bacterial ribosome as a target for antibiotics
J Poehlsgaard, S Douthwaite
Nature Reviews Microbiology 3 (11), 870-881, 2005
The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
LH Hansen, P Mauvais, S Douthwaite
Molecular microbiology 31 (2), 623-631, 1999
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs
SK Johansen, CE Maus, BB Plikaytis, S Douthwaite
Molecular cell 23 (2), 173-182, 2006
Basis for prokaryotic specificity of action of aminoglycoside antibiotics
MI Recht, S Douthwaite, JD Puglisi
The EMBO journal 18 (11), 3133-3138, 1999
The ketolides: a critical review
GG Zhanel, M Walters, A Noreddin, LM Vercaigne, A Wierzbowski, ...
Drugs 62, 1771-1804, 2002
Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
S Douthwaite, LH Hansen, P Mauvais
Molecular microbiology 36 (1), 183-193, 2000
Oxazolidinone Resistance Mutations in 23S rRNA of Escherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action
L Xiong, P Kloss, S Douthwaite, NM Andersen, S Swaney, ...
Journal of bacteriology 182 (19), 5325-5331, 2000
A “bulged” double helix in a RNA-protein contact site
DA Peattie, S Douthwaite, RA Garrett, HF and Noller
Proc. Natl. Acad. Sci. USA 78, 7331-7335, 1981
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage
B Vester, LB Lundberg, MD Sørensen, BR Babu, S Douthwaite, J Wengel
Journal of the American Chemical Society 124 (46), 13682-13683, 2002
Characterization of the binding sites of protein L11 and the L10.(L12) 4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli
J Egebjerg, SR Douthwaite, A Liljas, RA Garrett
Journal of molecular biology 213 (2), 275-288, 1990
Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site
S Douthwaite, WS Champney
Journal of Antimicrobial Chemotherapy 48 (suppl_2), 1-8, 2001
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A
G Rosendahl, S Douthwaite
Nucleic acids research 22 (3), 357-363, 1994
Mapping posttranscriptional modifications in 5S ribosomal RNA by MALDI mass spectrometry.
F Kirpekar, S Douthwaite, P Roepstorff
RNA 6 (2), 296-306, 2000
Macrolide Resistance by Ribosomal Mutation in Clinical Isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 Study
DJ Farrell, S Douthwaite, I Morrissey, S Bakker, J Poehlsgaard, ...
Antimicrobial agents and chemotherapy 47 (6), 1777-1783, 2003
Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA
D Moazed, BJ Van Stolk, S Douthwaite, HF Noller
Journal of molecular biology 191 (3), 483-493, 1986
YebU is a m5C methyltransferase specific for 16S rRNA nucleotide 1407
NM Andersen, S Douthwaite
Journal of molecular biology 359 (3), 777-786, 2006
Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction
MI Recht, S Douthwaite, KD Dahlquist, JD Puglisi
Journal of molecular biology 286 (1), 33-43, 1999
Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK
L Hidalgo, KL Hopkins, B Gutierrez, CM Ovejero, S Shukla, S Douthwaite, ...
Journal of Antimicrobial Chemotherapy 68, 1543-1550, 2013
Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA
M Liu, S Douthwaite
Antimicrobial Agents and Chemotherapy 46 (6), 1629-1633, 2002
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Straipsniai 1–20