Peter Tsvetkov

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Yosef ShaulProfessor of Biology, Weizmann Institute of ScienceVerified email at weizmann.ac.il
Sandro Santagata MD PhDBWH Pathology | HMS Laboratory of Systems Pharmacology | HMS Department of SysBioVerified email at bics.bwh.harvard.edu
Gad AsherDepartment of Biomolecular Sciences, Weizmann Institute of ScienceVerified email at weizmann.ac.il
Yaarit AdamovichStaff Scientist, Weizmann Institute of ScienceVerified email at weizmann.ac.il
Irene GhobrialDana-Farber Cancer InstituteVerified email at dfci.harvard.edu
Aviad TsherniakBroad Institute of Harvard and MITVerified email at broadinstitute.org
Alexandre DetappeInstitut de Cancérologie Strasbourg Europe/Strasbourg University, FranceVerified email at icans.eu
Evan ElliottAssociate Professor Bar Ilan UniversityVerified email at biu.ac.il
Can KayatekinHarvard Department of Stem Cell and Regenerative BiologyVerified email at g.harvard.edu
Aviv PazHauptman-Woodward Medical Research InstituteVerified email at hwi.buffalo.edu
Joel SussmanWeizmann Institute of ScienceVerified email at weizmann.ac.il
Amir ShlomaiHead, Department of Medicine D and the Laboratory of Liver Research, The Liver Institute, RabinVerified email at post.tau.ac.il
Josef PenningerLife Sciences Institute, University of British Columbia / IMBA Institut für MolekulareVerified email at imba.oeaw.ac.at
Marc MendilloAssociate Professor, Northwestern UniversityVerified email at northwestern.edu
Thijn BrummelkampGroupleader, Netherlands Cancer InstituteVerified email at nki.nl
Simon CookSignalling Programme, The Babraham InstituteVerified email at babraham.ac.uk
Ahmad S KhalilBoston University & Wyss Institute at Harvard UniversityVerified email at bu.edu
Mahmoud GhandiBroad Institute of MIT and HarvardVerified email at broadinstitute.org
Levi GarrawayAssociate Professor of Medicine, Harvard Medical SchoolVerified email at dfci.harvard.edu
Uri Ben-DavidTel Aviv UniversityVerified email at tauex.tau.ac.il

Peter Tsvetkov

Research Scientist Group Leader, Broad Institute

Verified email at broadinstitute.org - Homepage

protein homeostasis cancer metabolism cell death drug-resistance copper


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Copper induces cell death by targeting lipoylated TCA cycle proteins P Tsvetkov, S Coy, B Petrova, M Dreishpoon, A Verma, M Abdusamad, ... Science 375 (6586), 1254-1261, 2022	1905	2022
Genetic and transcriptional evolution alters cancer cell line drug response U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ... Nature 560 (7718), 325-330, 2018	808	2018
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73 G Asher, P Tsvetkov, C Kahana, Y Shaul Genes & development 19 (3), 316-321, 2005	430	2005
Mitochondrial metabolism promotes adaptation to proteotoxic stress P Tsvetkov, A Detappe, K Cai, HR Keys, Z Brune, W Ying, P Thiru, ... Nature chemical biology 15 (7), 681-689, 2019	334	2019
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1 G Asher, Z Bercovich, P Tsvetkov, Y Shaul, C Kahana Molecular cell 17 (5), 645-655, 2005	194	2005
The crystal structure of NAD (P) H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol G Asher, O Dym, P Tsvetkov, J Adler, Y Shaul Biochemistry 45 (20), 6372-6378, 2006	186	2006
Inhibition of NAD (P) H: quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin P Tsvetkov, G Asher, V Reiss, Y Shaul, L Sachs, J Lotem Proceedings of the National Academy of Sciences 102 (15), 5535-5540, 2005	180	2005
Ubiquitin-independent p53 proteasomal degradation P Tsvetkov, N Reuven, Y Shaul Cell Death & Differentiation 17 (1), 103-108, 2010	162	2010
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome P Tsvetkov, G Asher, A Paz, N Reuven, JL Sussman, I Silman, Y Shaul Proteins: Structure, Function, and Bioinformatics 70 (4), 1357-1366, 2008	133	2008
BAG-1 associates with Hsc70· Tau complex and regulates the proteasomal degradation of Tau protein E Elliott, P Tsvetkov, I Ginzburg Journal of biological chemistry 282 (51), 37276-37284, 2007	132	2007
The nanny model for IDPs P Tsvetkov, N Reuven, Y Shaul Nature chemical biology 5 (11), 778-781, 2009	130	2009
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1 O Moscovitz, P Tsvetkov, N Hazan, I Michaelevski, H Keisar, ... Molecular cell 47 (1), 76-86, 2012	111	2012
The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1 Y Adamovich, A Shlomai, P Tsvetkov, KB Umansky, N Reuven, JL Estall, ... Molecular and cellular biology 33 (13), 2603-2613, 2013	107	2013
The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets N Pode‐Shakked, R Shukrun, M Mark‐Danieli, P Tsvetkov, S Bahar, ... EMBO molecular medicine 5 (1), 18-37, 2013	96	2013
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome P Tsvetkov, ML Mendillo, J Zhao, JE Carette, PH Merrill, D Cikes, ... elife 4, e08467, 2015	86	2015
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD (P) H: quinone oxidoreductase 1 G Asher, J Lotem, P Tsvetkov, V Reiss, L Sachs, Y Shaul Proceedings of the National Academy of Sciences 100 (25), 15065-15070, 2003	86	2003
BIM_EL, an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation CM Wiggins, P Tsvetkov, M Johnson, CL Joyce, CA Lamb, NJ Bryant, ... Journal of cell science 124 (6), 969-977, 2011	81	2011
E3 ligase STUB1/CHIP regulates NAD (P) H: quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients P Tsvetkov, Y Adamovich, E Elliott, Y Shaul Journal of biological chemistry 286 (11), 8839-8845, 2011	73	2011
A genetic tool to track protein aggregates and control prion inheritance GA Newby, S Kiriakov, E Hallacli, C Kayatekin, P Tsvetkov, CP Mancuso, ... Cell 171 (4), 966-979. e18, 2017	70	2017
Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response*♦ P Tsvetkov, N Reuven, C Prives, Y Shaul Journal of biological chemistry 284 (39), 26234-26242, 2009	68	2009

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