Lars Zender
Lars Zender
Professor of Medical Oncology, Director & Chair, Dept. of Medical Oncology & Pneumology, University Hospital Tübingen, 72076 Tübingen, Germany
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A microRNA component of the p53 tumour suppressor network
L He, X He, LP Lim, E De Stanchina, Z Xuan, Y Liang, W Xue, L Zender, ...
Nature 447 (7148), 1130-1134, 2007
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
W Xue, L Zender, C Miething, RA Dickins, E Hernando, V Krizhanovsky, ...
Nature 445 (7128), 656-660, 2007
Senescence of activated stellate cells limits liver fibrosis
V Krizhanovsky, M Yon, RA Dickins, S Hearn, J Simon, C Miething, H Yee, ...
Cell 134 (4), 657-667, 2008
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
JC Acosta, A Banito, T Wuestefeld, A Georgilis, P Janich, JP Morton, ...
Nature cell biology 15 (8), 978-990, 2013
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Nature 7374 (Nov 9;479), 547-51, 2011
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
L Zender, MS Spector, W Xue, P Flemming, C Cordon-Cardo, J Silke, ...
Cell 125 (7), 1253-1267, 2006
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
S Glück, B Guey, MF Gulen, K Wolter, TW Kang, NA Schmacke, ...
Nature cell biology 19 (9), 1061-1070, 2017
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
D Pfister, NG Núñez, R Pinyol, O Govaere, M Pinter, M Szydlowska, ...
Nature 592 (7854), 450-456, 2021
T-helper-1-cell cytokines drive cancer into senescence
H Braumüller, T Wieder, E Brenner, S Aßmann, M Hahn, M Alkhaled, ...
Nature 494 (7437), 361-365, 2013
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
N Herranz, S Gallage, M Mellone, T Wuestefeld, S Klotz, CJ Hanley, ...
Nature cell biology 17 (9), 1205-1217, 2015
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
SU Wiemann, A Satyanarayana, M Tsahuridu, HL Tillmann, L Zender, ...
The FASEB journal 16 (9), 935-942, 2002
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
B Ritschka, M Storer, A Mas, F Heinzmann, MC Ortells, JP Morton, ...
Genes & development 31 (2), 172-183, 2017
Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma
MZ Xu, TJ Yao, NPY Lee, IOL Ng, YT Chan, L Zender, SW Lowe, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2009
Caspase 8 small interfering RNA prevents acute liver failure in mice
L Zender, S Hütker, C Liedtke, HL Tillmann, S Zender, B Mundt, ...
Proceedings of the National Academy of Sciences 100 (13), 7797-7802, 2003
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
S Walz, F Lorenzin, J Morton, KE Wiese, B Von Eyss, S Herold, L Rycak, ...
Nature 511 (7510), 483-487, 2014
Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression
T Eggert, K Wolter, J Ji, C Ma, T Yevsa, S Klotz, J Medina-Echeverz, ...
Cancer cell 30 (4), 533-547, 2016
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
L Zender, W Xue, J Zuber, CP Semighini, A Krasnitz, B Ma, P Zender, ...
Cell 135 (5), 852-864, 2008
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening
ET Sawey, M Chanrion, C Cai, G Wu, J Zhang, L Zender, A Zhao, ...
Cancer cell 19 (3), 347-358, 2011
NOTCH1 mediates a switch between two distinct secretomes during senescence
M Hoare, Y Ito, TW Kang, MP Weekes, NJ Matheson, DA Patten, S Shetty, ...
Nature cell biology 18 (9), 979-992, 2016
Topoisomerase levels determine chemotherapy response in vitro and in vivo
DJ Burgess, J Doles, L Zender, W Xue, B Ma, WR McCombie, GJ Hannon, ...
Proceedings of the National Academy of Sciences 105 (26), 9053-9058, 2008
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