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Yi-Chun Lin
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A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
WM Botello-Smith, W Jiang, H Zhang, AD Ozkan, YC Lin, CN Pham, ...
Nature communications 10 (1), 4503, 2019
1682019
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia
X He, Y Zhu, YC Lin, M Li, J Du, H Dong, J Sun, L Zhu, H Wang, Z Ding, ...
Blood, The Journal of the American Society of Hematology 134 (6), 548-560, 2019
612019
Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
W Jiang, JS Del Rosario, W Botello-Smith, S Zhao, Y Lin, H Zhang, ...
Communications Biology 4 (1), 84, 2021
372021
Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia
Y Zhu, X He, YC Lin, H Dong, L Zhang, X Chen, Z Wang, Y Shen, M Li, ...
Blood, The Journal of the American Society of Hematology 134 (15), 1257-1268, 2019
312019
Mechanical properties of anionic asymmetric bilayers from atomistic simulations
W Jiang, YC Lin, YL Luo
The Journal of Chemical Physics 154 (22), 2021
82021
Free energy and kinetics of cAMP permeation through connexin26 via applied voltage and milestoning
W Jiang, YC Lin, W Botello-Smith, JE Contreras, AL Harris, L Maragliano, ...
Biophysical Journal 120 (15), 2969-2983, 2021
52021
Structural and thermodynamic framework for PIEZO1 modulation by small molecules
W Jiang, TD Wijerathne, H Zhang, YC Lin, S Jo, W Im, JJ Lacroix, YL Luo
Proceedings of the National Academy of Sciences 120 (50), e2310933120, 2023
22023
Binding Free Energies of Piezo1 Channel Agonists at Protein-Membrane Interface
W Jiang, H Zhang, W Im, JJ Lacroix, YL Luo
bioRxiv, 2022.06. 27.497657, 2022
22022
Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltage
W Jiang, YC Lin, W Botello-Smith, J Contreras, AL Harris, L Maragliano, ...
bioRxiv, 2021.01. 18.427208, 2021
12021
A piezo1 open state reveals a multi-fenestrated ion permeation pathway
W Jiang, JS Del Rosario, W Botello-Smith, S Zhao, Y Lin, H Zhang, ...
bioRxiv, 2020.03. 12.988378, 2020
12020
Large-pore connexin hemichannels function as molecule transporters independently of ion conduction
PS Gaete, D Kumar, CI Fernandez, JM Valdez-Capuccino, A Bhatt, ...
bioRxiv, 2024.02. 20.581300, 2024
2024
Refining HCN1 channel closed and open state models using cysteine bridge simulations
YC Lin, PH Larsson, YL Luo
Biophysical journal 122 (3), 193a, 2023
2023
Rationale design of novel PIEZO1 modulators
W Jiang, TD Wijerathne, H Zhang, YC Lin, W Im, JJ Lacroix, YL Luo
Biophysical Journal 122 (3), 396a, 2023
2023
Small molecule permeation through a wide-pore channel via applied voltage and Markovian milestoning
YC Lin, W Jiang, YL Luo
Biophysical Journal 121 (3), 248a, 2022
2022
Computer simulations of Piezo1 channel regulation by membrane and small molecule
YL Luo, W Jiang, YC Lin, H Zhang, WM Botello-Smith
Biophysical Journal 121 (3), 187a-188a, 2022
2022
Single-Channel Permeability from Markovian Milestoning, Umbrella Sampling, and Voltage Simulations
YC Lin, Y Luo
2021
An Open State Was Induced by Mimicking Mechanosensitive Piezo1 Channel Clusters in Molecular Dynamic Simulations
W Jiang, J Del Rosario, WM Botello-Smith, S Zhao, Y Lin, H Zhang, ...
Biophysical Journal 120 (3), 228a, 2021
2021
In Silico Transmission of Cyclic Amp through Connexin 26 via Milestoning and External Electric Field Molecular Dynamics Simulations
WM Botello-Smith, Y Lin, W Jiang, L Maragliano, JE Contreras, AL Harris, ...
Biophysical Journal 120 (3), 178a, 2021
2021
Molecular Dynamics Simulation of pH-Mediated Conformational Change in Connexin Channels
C Sen, WM Botello-Smith, YC Lin, YL Luo
Biophysical Journal 120 (3), 228a, 2021
2021
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Articles 1–19