William R. Sellers
William R. Sellers
Core Institute Member, The Broad Institute
Verified email at
Cited by
Cited by
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich, S Gabriel, P Herman, ...
Science 304 (5676), 1497-1500, 2004
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
J Barretina, G Caponigro, N Stransky, K Venkatesan, AA Margolin, S Kim, ...
Nature 483 (7391), 603-607, 2012
The landscape of somatic copy-number alteration across human cancers
R Beroukhim, CH Mermel, D Porter, G Wei, S Raychaudhuri, J Donovan, ...
Nature 463 (7283), 899-905, 2010
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
RL Levine, M Wadleigh, J Cools, BL Ebert, G Wernig, BJP Huntly, ...
Cancer cell 7 (4), 387-397, 2005
Gene expression correlates of clinical prostate cancer behavior
D Singh, PG Febbo, K Ross, DG Jackson, J Manola, C Ladd, P Tamayo, ...
Cancer cell 1 (2), 203-209, 2002
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
LA Garraway, HR Widlund, MA Rubin, G Getz, AJ Berger, S Ramaswamy, ...
Nature 436 (7047), 117-122, 2005
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
CM Johannessen, JS Boehm, SY Kim, SR Thomas, L Wardwell, ...
Nature 468 (7326), 968-972, 2010
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
IK Mellinghoff, MY Wang, I Vivanco, DA Haas-Kogan, S Zhu, EQ Dia, ...
New England Journal of Medicine 353 (19), 2012-2024, 2005
Molecular characterization of the tumor microenvironment in breast cancer
M Allinen, R Beroukhim, L Cai, C Brennan, J Lahti-Domenici, H Huang, ...
Cancer cell 6 (1), 17-32, 2004
BRAF mutation predicts sensitivity to MEK inhibition
DB Solit, LA Garraway, CA Pratilas, A Sawai, G Getz, A Basso, Q Ye, ...
Nature 439 (7074), 358-362, 2006
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo …
SM Maira, F Stauffer, J Brueggen, P Furet, C Schnell, C Fritsch, ...
Molecular cancer therapeutics 7 (7), 1851-1863, 2008
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
H Gao, JM Korn, S Ferretti, JE Monahan, Y Wang, M Singh, C Zhang, ...
Nature medicine 21 (11), 1318-1325, 2015
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
I Sansal, WR Sellers
Journal of clinical oncology 22 (14), 2954-2963, 2004
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
R Beroukhim, G Getz, L Nghiemphu, J Barretina, T Hsueh, D Linhart, ...
Proceedings of the National Academy of Sciences 104 (50), 20007-20012, 2007
High-throughput oncogene mutation profiling in human cancer
RK Thomas, AC Baker, RM DeBiasi, W Winckler, T LaFramboise, WM Lin, ...
Nature genetics 39 (3), 347-351, 2007
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder, PG Febbo, R Bikoff, R Berger, Q Xue, LM McMahon, ...
Nature medicine 10 (6), 594-601, 2004
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
WG Kaelin Jr, W Krek, WR Sellers, JA DeCaprio, F Ajchenbaum, ...
Cell 70 (2), 351-364, 1992
Phosphorylation of the PTEN tail regulates protein stability and function
F Vazquez, S Ramaswamy, N Nakamura, WR Sellers
Molecular and cellular biology 20 (14), 5010-5018, 2000
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
ME McMenamin, P Soung, S Perera, I Kaplan, M Loda, WR Sellers
Cancer research 59 (17), 4291-4296, 1999
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