Laurence Pearl
Laurence Pearl
Professor of Structural Biology, University of Sussex
Patvirtintas el. paštas - Pagrindinis puslapis
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, LH Pearl
Cell 90 (1), 65-75, 1997
Structure and mechanism of the Hsp90 molecular chaperone machinery
LH Pearl, C Prodromou
Annu. Rev. Biochem. 75, 271-294, 2006
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
SM Roe, C Prodromou, R O'Brien, JE Ladbury, PW Piper, LH Pearl
Journal of medicinal chemistry 42 (2), 260-266, 1999
Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
MMU Ali, SM Roe, CK Vaughan, P Meyer, B Panaretou, PW Piper, ...
Nature 440 (7087), 1013-1017, 2006
GSK-3-selective inhibitors derived from Tyrian purple indirubins
L Meijer, AL Skaltsounis, P Magiatis, P Polychronopoulos, M Knockaert, ...
Chemistry & biology 10 (12), 1255-1266, 2003
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
B Panaretou, C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, ...
The EMBO journal 17 (16), 4829-4836, 1998
A structural model for the retroviral proteases
LH Pearl, WR Taylor
Nature 329 (6137), 351-354, 1987
Crystal structure of glycogen synthase kinase 3β: structural basis for phosphate-primed substrate specificity and autoinhibition
R Dajani, E Fraser, SM Roe, N Young, V Good, TC Dale, LH Pearl
Cell 105 (6), 721-732, 2001
DNA repair, genome stability and cancer: a historical perspective
PA Jeggo, LH Pearl, AM Carr
Nature Reviews Cancer 16 (1), 35-42, 2016
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1
B Panaretou, G Siligardi, P Meyer, A Maloney, JK Sullivan, S Singh, ...
Molecular cell 10 (6), 1307-1318, 2002
The ATPase cycle of Hsp90 drives a molecular ‘clamp’via transient dimerization of the N-terminal domains
C Prodromou, B Panaretou, S Chohan, G Siligardi, R O'Brien, JE Ladbury, ...
The EMBO journal 19 (16), 4383-4392, 2000
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions
P Meyer, C Prodromou, B Hu, C Vaughan, SM Roe, B Panaretou, ...
Molecular cell 11 (3), 647-658, 2003
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
C Prodromou, G Siligardi, R O'Brien, DN Woolfson, L Regan, B Panaretou, ...
The EMBO journal 18 (3), 754-762, 1999
The structural basis of specific base-excision repair by uracil–DNA glycosylase
R Savva, K McAuley-Hecht, T Brown, L Pearl
Nature 373 (6514), 487-493, 1995
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ...
Cancer research 68 (8), 2850-2860, 2008
The Hsp90 molecular chaperone: an open and shut case for treatment
LH Pearl, C Prodromou, P Workman
Biochemical Journal 410 (3), 439-453, 2008
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases
P Polychronopoulos, P Magiatis, AL Skaltsounis, V Myrianthopoulos, ...
Journal of medicinal chemistry 47 (4), 935-946, 2004
4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ...
Journal of medicinal chemistry 51 (2), 196-218, 2008
Therapeutic opportunities within the DNA damage response
LH Pearl, AC Schierz, SE Ward, B Al-Lazikani, FMG Pearl
Nature Reviews Cancer 15 (3), 166-180, 2015
Structure and function in the uracil-DNA glycosylase superfamily
LH Pearl
Mutation Research/DNA Repair 460 (3-4), 165-181, 2000
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Straipsniai 1–20