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Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells T Vogiatzi, M Xilouri, K Vekrellis, L Stefanis Journal of Biological Chemistry 283 (35), 23542-23556, 2008 | 757 | 2008 |
Pathological roles of α-synuclein in neurological disorders K Vekrellis, M Xilouri, E Emmanouilidou, HJ Rideout, L Stefanis The Lancet Neurology 10 (11), 1015-1025, 2011 | 460 | 2011 |
Abberant α-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy M Xilouri, T Vogiatzi, K Vekrellis, D Park, L Stefanis PloS one 4 (5), e5515, 2009 | 411 | 2009 |
ER stress and autophagic perturbations lead to elevated extracellular α-synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons HJR Fernandes, EM Hartfield, HC Christian, E Emmanoulidou, Y Zheng, ... Stem cell reports 6 (3), 342-356, 2016 | 355 | 2016 |
Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome E Emmanouilidou, L Stefanis, K Vekrellis Neurobiology of aging 31 (6), 953-968, 2010 | 269 | 2010 |
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy M Papadakis, G Hadley, M Xilouri, LC Hoyte, S Nagel, MM McMenamin, ... Nature medicine 19 (3), 351-357, 2013 | 235 | 2013 |
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype G Minakaki, S Menges, A Kittel, E Emmanouilidou, I Schaeffner, ... Autophagy 14 (1), 98-119, 2018 | 229 | 2018 |
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How is alpha‐synuclein cleared from the cell? L Stefanis, E Emmanouilidou, M Pantazopoulou, D Kirik, K Vekrellis, ... Journal of neurochemistry 150 (5), 577-590, 2019 | 166 | 2019 |
Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice M Karampetsou, MT Ardah, M Semitekolou, A Polissidis, M Samiotaki, ... Scientific reports 7 (1), 16533, 2017 | 155 | 2017 |
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Inducible over‐expression of wild type α‐synuclein in human neuronal cells leads to caspase‐dependent non‐apoptotic death K Vekrellis, M Xilouri, E Emmanouilidou, L Stefanis Journal of neurochemistry 109 (5), 1348-1362, 2009 | 138 | 2009 |
Neurobiology of α-synuclein K Vekrellis, HJ Rideout, L Stefanis Molecular neurobiology 30, 1-21, 2004 | 137 | 2004 |
Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling J Xu, M Xilouri, J Bruban, J Shioi, Z Shao, I Papazoglou, K Vekrellis, ... Neurobiology of aging 32 (12), 2326. e5-2326. e16, 2011 | 114 | 2011 |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption I Pediaditakis, KR Kodella, DV Manatakis, CY Le, CD Hinojosa, ... Nature communications 12 (1), 5907, 2021 | 109 | 2021 |
Cellular models of alpha‐synuclein toxicity and aggregation M Delenclos, JD Burgess, A Lamprokostopoulou, TF Outeiro, K Vekrellis, ... Journal of neurochemistry 150 (5), 566-576, 2019 | 101 | 2019 |
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson’s disease VE Papadopoulos, G Nikolopoulou, I Antoniadou, A Karachaliou, ... Human molecular genetics 27 (10), 1696-1710, 2018 | 98 | 2018 |
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease LMA Oliveira, T Gasser, R Edwards, M Zweckstetter, R Melki, L Stefanis, ... npj Parkinson's Disease 7 (1), 65, 2021 | 97 | 2021 |
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity O Chutna, S Gonçalves, A Villar-Piqué, P Guerreiro, Z Marijanovic, ... Human molecular genetics 23 (25), 6732-6745, 2014 | 95 | 2014 |