| Molecular Genetics and Epidemiology of the NAT1 and NAT2 Acetylation Polymorphisms DW Hein, MA Doll, AJ Fretland, MA Leff, SJ Webb, GH Xiao, ... Cancer Epidemiology Biomarkers & Prevention 9 (1), 29-42, 2000 | 933 | 2000 |
| Epoxide hydrolases: biochemistry and molecular biology AJ Fretland, CJ Omiecinski Chemico-biological interactions 129 (1-2), 41-59, 2000 | 377 | 2000 |
| Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms AJ Fretland, MA Leff, MA Doll, DW Hein Pharmacogenetics and Genomics 11 (3), 207-215, 2001 | 181 | 2001 |
| Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas N Ishibe, R Sinha, DW Hein, M Kulldorff, P Strickland, AJ Fretland, ... Pharmacogenetics and Genomics 12 (2), 145-150, 2002 | 135 | 2002 |
| Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype MA Leff, AJ Fretland, MA Doll, DW Hein Journal of Biological Chemistry 274 (49), 34519-34522, 1999 | 100 | 1999 |
| Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug MLT Vieira, B Kirby, I Ragueneau‐Majlessi, A Galetin, JYL Chien, ... Clinical Pharmacology & Therapeutics 95 (2), 189-198, 2014 | 89 | 2014 |
| Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant … Y Chen, L Liu, K Nguyen, AJ Fretland Drug metabolism and disposition 39 (3), 373-382, 2011 | 89 | 2011 |
| Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases DW Hein, MA Doll, AJ Fretland, K Gray, AC Deitz, Y Feng, W Jiang, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997 | 87 | 1997 |
| Dietary selenium reduces the formation of aberrant crypts in rats administered 3, 2′-dimethyl-4-aminobiphenyl Y Feng, JW Finley, CD Davis, WK Becker, AJ Fretland, DW Hein Toxicology and applied pharmacology 157 (1), 36-42, 1999 | 84 | 1999 |
| Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1 AJ Fretland, MA Doll, MA Leff, DW Hein Pharmacogenetics and Genomics 11 (6), 511-520, 2001 | 82 | 2001 |
| Determination of HumanNAT2Acetylator Genotype by Restriction Fragment-Length Polymorphism and Allele-Specific Amplification MA Doll, AJ Fretland, AC Deitz, DW Hein Analytical biochemistry 231 (2), 413-420, 1995 | 78 | 1995 |
| Improving the accuracy of predicted human pharmacokinetics: lessons learned from the AstraZeneca drug pipeline over two decades M Davies, RDO Jones, K Grime, R Jansson-Löfmark, AJ Fretland, ... Trends in pharmacological sciences 41 (6), 390-408, 2020 | 76 | 2020 |
| Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts Y Qian, M Hamilton, A Sidduri, S Gabriel, Y Ren, R Peng, R Kondru, ... Journal of medicinal chemistry 55 (17), 7920-7939, 2012 | 69 | 2012 |
| Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse MA Leff, PN Epstein, MA Doll, AJ Fretland, US Devanaboyina, TD Rustan, ... Journal of pharmacology and experimental therapeutics 290 (1), 182-187, 1999 | 67 | 1999 |
| Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype WM O'Neil, RK Drobitch, RD MacArthur, MJ Farrough, MA Doll, ... Pharmacogenetics and Genomics 10 (2), 171-182, 2000 | 62 | 2000 |
| Cloning, Sequencing, and Recombinant Expression ofNAT1, NAT2, andNAT3Derived from the C3H/HeJ (Rapid) and A/HeJ (Slow) Acetylator Inbred Mouse: Functional Characterization of … AJ Fretland, MA Doll, K Gray, Y Feng, DW Hein Toxicology and applied pharmacology 142 (2), 360-366, 1997 | 60 | 1997 |
| Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions Y Chen, L Liu, M Monshouwer, AJ Fretland Drug metabolism and disposition 39 (11), 2085-2092, 2011 | 58 | 2011 |
| Tissue distribution of N‐acetyltransferase 1 and 2 catalyzing the N‐acetylation of 4‐aminobiphenyl and O‐acetylation of N‐hydroxy‐4‐aminobiphenyl in the … DW Hein, MA Doll, DE Nerland, AJ Fretland Molecular Carcinogenesis: Published in cooperation with the University of …, 2006 | 56 | 2006 |
| Effects of single nucleotide polymorphisms in human N‐acetyltransferase 2 on metabolic activation (O‐acetylation) of heterocyclic amine carcinogens DW Hein, AJ Fretland, MA Doll International journal of cancer 119 (5), 1208-1211, 2006 | 54 | 2006 |
| Acetylator phenotype and genotype in HIV‐infected patients with and without sulfonamide hypersensitivity WM O'Neil, RD MacArthur, MJ Farrough, MA Doll, AJ Fretland, DW Hein, ... The Journal of Clinical Pharmacology 42 (6), 613-619, 2002 | 44 | 2002 |
