Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis A Frattini, PJ Orchard, C Sobacchi, S Giliani, M Abinun, JP Mattsson, ... Nature genetics 25 (3), 343-346, 2000 | 818 | 2000 |
Pharmacological aspects of acid secretion BI Hirschowitz, D Keeling, M Lewin, S Okabe, M Parsons, K Sewing, ... Digestive diseases and sciences 40, 3S-23S, 1995 | 156 | 1995 |
Components of successful lead generation AM Davis, DJ Keeling, J Steele, NP Tomkinson, AC Tinker Current topics in medicinal chemistry 5 (4), 421-439, 2005 | 135 | 2005 |
Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2, 4-diaminoquinazolines and thienopyrimidines RJ Ife, TH Brown, P Blurton, DJ Keeling, CA Leach, ML Meeson, ... Journal of medicinal chemistry 38 (14), 2763-2773, 1995 | 110 | 1995 |
Esomeprazole—enhanced bio‐availability, specificity for the proton pump and inhibition of acid secretion P Lindberg, D Keeling, J Fryklund, T Andersson, P Lundborg, E Carlsson Alimentary pharmacology & therapeutics 17 (4), 481-488, 2003 | 104 | 2003 |
Studies on the mechanism of action of omeprazole DJ Keeling, C Fallowfield, KJ Milliner, SK Tingley, RJ Ife, AH Underwood Biochemical pharmacology 34 (16), 2967-2973, 1985 | 101 | 1985 |
Isolation and reconstitution of a vacuolar-type proton pump of osteoclast membranes. JP Mattsson, PH Schlesinger, DJ Keeling, SL Teitelbaum, DK Stone, ... Journal of Biological Chemistry 269 (40), 24979-24982, 1994 | 93 | 1994 |
Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino) quinolines RJ Ife, TH Brown, DJ Keeling, CA Leach, ML Meeson, ME Parsons, ... Journal of medicinal chemistry 35 (18), 3413-3422, 1992 | 86 | 1992 |
SCH 28080 is a lumenally acting, K+-site inhibitor of the gastric (H++ K+)-ATPase DJ Keeling, SM Laing, J Senn-Bilfinger Biochemical pharmacology 37 (11), 2231-2236, 1988 | 85 | 1988 |
Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo [3, 2-c] quinolines as conformationally restrained analogs of 4-(arylamino) quinolines TH Brown, RJ Ife, DJ Keeling, SM Laing, CA Leach, ME Parsons, ... Journal of medicinal chemistry 33 (2), 527-533, 1990 | 79 | 1990 |
The binding of a K+ competitive ligand, 2-methyl, 8-(phenylmethoxy) imidazo (1, 2-a) pyridine 3-acetonitrile, to the gastric (H++ K+)-ATPase DJ Keeling, AG Taylor, C Schudt Journal of Biological Chemistry 264 (10), 5545-5551, 1989 | 78 | 1989 |
By 1023/SK&F 96022: Biochemistry of a novel (H++ K+-ATPase inhibitor WA Simon, DJ Keeling, SM Laing, C Fallowfield, AG Taylor Biochemical pharmacology 39 (11), 1799-1806, 1990 | 77 | 1990 |
Novel approaches to the pharmacological blockade of gastric acid secretion ME Parsons, DJ Keeling Expert opinion on investigational drugs 14 (4), 411-421, 2005 | 76 | 2005 |
Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo [3, 2-c] quinolines: effect of the 4-substituent CA Leach, TH Brown, RJ Ife, DJ Keeling, SM Laing, ME Parsons, ... Journal of medicinal chemistry 35 (10), 1845-1852, 1992 | 76 | 1992 |
The specificity of omeprazole as an (H++ K+)-ATPase inhibitor depends upon the means of its activation DJ Keeling, C Fallowfield, AH Underwood Biochemical pharmacology 36 (3), 339-344, 1987 | 74 | 1987 |
Subunit G of the vacuolar proton pump: molecular characterization and functional expression BP Crider, P Andersen, AE White, Z Zhou, X Li, JP Mattsson, L Lundberg, ... Journal of Biological Chemistry 272 (16), 10721-10728, 1997 | 67 | 1997 |
Cell biology of gastric acid secretion HF Helander, DJ Keeling Baillière's clinical gastroenterology 7 (1), 1-21, 1993 | 61 | 1993 |
Vacuolar H+‐ATPases Targets for Drug Discovery? DJ Keeling, M Herslöf, B Ryberg, S Sjögren, L Sölvell Annals of the New York Academy of Sciences 834 (1), 600-608, 1997 | 55 | 1997 |
2-[[(4-Amino-2-pyridyl) methyl] sulfinyl] benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity RJ Ife, CA Dyke, DJ Keeling, E Meenan, ML Meeson, ME Parsons, ... Journal of medicinal chemistry 32 (8), 1970-1977, 1989 | 55 | 1989 |
Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma M Liljevald, M Rehnberg, M Söderberg, M Ramnegård, J Börjesson, ... Autoimmunity reviews 15 (11), 1062-1070, 2016 | 52 | 2016 |