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Shivashankar Othy
Shivashankar Othy
Assistant Professor, Dept. of Physiology & Biophysics, UC Irvine School of Medicine
Verified email at uci.edu - Homepage
Title
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Cited by
Year
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
H Atcha, A Jairaman, JR Holt, VS Meli, RR Nagalla, ...
Nature communications 12 (1), 3256, 2021
2832021
Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming
MP Matheu, S Othy, ML Greenberg, TX Dong, M Schuijs, K Deswarte, ...
Nature communications 6 (1), 6219, 2015
1382015
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
F Marangoni, A Zhakyp, M Corsini, SN Geels, E Carrizosa, M Thelen, ...
Cell 184 (15), 3998-4015. e19, 2021
1272021
Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses
JL Bolton, AK Short, S Othy, CL Kooiker, M Shao, BG Gunn, J Beck, X Bai, ...
Cell reports 38 (13), 2022
892022
Immunomodulation by intravenous immunoglobulin: role of regulatory T cells
MS Maddur, S Othy, P Hegde, J Vani, S Lacroix-Desmazes, J Bayry, ...
Journal of Clinical Immunology 30, 4-8, 2010
872010
T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse
TX Dong, S Othy, A Jairaman, J Skupsky, A Zavala, I Parker, JL Dynes, ...
Elife 6, e32417, 2017
772017
Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine …
S Othy, P Hegde, S Topçu, M Sharma, MS Maddur, S Lacroix-Desmazes, ...
The Journal of Immunology 190 (9), 4535-4541, 2013
732013
Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses
A Jairaman, S Othy, JL Dynes, AV Yeromin, A Zavala, ML Greenberg, ...
Science advances 7 (28), eabg5859, 2021
672021
Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation
S Othy, A Jairaman, JL Dynes, TX Dong, C Tune, AV Yeromin, A Zavala, ...
Proceedings of the National Academy of Sciences 117 (33), 20088-20099, 2020
582020
Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant
LL McIntyre, SA Greilach, S Othy, I Sears-Kraxberger, B Wi, ...
Neurobiology of disease 140, 104868, 2020
562020
Sialylation may be dispensable for reciprocal modulation of helper T cells by intravenous immunoglobulin
S Othy, S Topçu, C Saha, P Kothapalli, S Lacroix‐Desmazes, ...
European journal of immunology 44 (7), 2059-2063, 2014
522014
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
A Jairaman, A McQuade, A Granzotto, YJ Kang, JP Chadarevian, ...
Elife 11, e73021, 2022
442022
Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility
TX Dong, S Othy, ML Greenberg, A Jairaman, C Akunwafo, S Leverrier, ...
Elife 6, e27827, 2017
412017
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
G Coulis, D Jaime, C Guerrero-Juarez, JM Kastenschmidt, PK Farahat, ...
Science advances 9 (27), eadd9984, 2023
342023
Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: role of lipid accumulation
S Othy, P Bruneval, S Topçu, I Dugail, F Delers, S Lacroix-Desmazes, ...
Journal of autoimmunity 39 (3), 168-172, 2012
242012
Cxcl17 -/- mice develop exacerbated disease in a T cell-dependent autoimmune model
M Hernández-Ruiz, S Othy, C Herrera, HT Nguyen, G Arrevillaga-Boni, ...
Journal of leukocyte biology 105 (5), 1027-1039, 2019
192019
Calcium dynamics in astrocytes during cell injury
NM Wakida, V Gomez-Godinez, H Li, J Nguyen, EK Kim, JL Dynes, S Othy, ...
Frontiers in Bioengineering and Biotechnology 8, 912, 2020
182020
Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis
S Othy, S Topçu, SV Kaveri, J Bayry
Proceedings of the National Academy of Sciences 109 (37), E2412-E2413, 2012
102012
Imaging regulatory T cell dynamics and suppression of T cell priming mediated by CTLA4
MP Matheu, S Othy, ML Greenberg, TX Dong, M Schuijs, K Deswarte, ...
Nature communications 6, 6219, 2015
62015
Interruption of the intratumor CD8+ T cell: Treg crosstalk improves the efficacy of PD-1 immunotherapy
SN Geels, A Moshensky, RS Sousa, C Murat, MA Bustos, BL Walker, ...
Cancer Cell 42 (6), 1051-1066. e7, 2024
42024
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