Koen Augustyns
Koen Augustyns
Full professor, Medicinal Chemistry, University of Antwerp
Verified email at - Homepage
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Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
AM Lambeir, P Proost, C Durinx, G Bal, K Senten, K Augustyns, ...
Journal of Biological Chemistry 276 (32), 29839-29845, 2001
Truncation of macrophage-derived chemokine by CD26/dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction
P Proost, S Struyf, D Schols, G Opdenakker, S Sozzani, P Allavena, ...
Journal of Biological Chemistry 274 (7), 3988-3993, 1999
In vitro antioxidant profile of phenolic acid derivatives
P Cos, P Rajan, I Vedernikova, M Calomme, L Pieters, AJ Vlietinck, ...
Free radical research 36 (6), 711-716, 2002
Synthesis and evaluation of caffeic acid amides as antioxidants
P Rajan, I Vedernikova, P Cos, DV Berghe, K Augustyns, A Haemers
Bioorganic & Medicinal Chemistry Letters 11 (2), 215-217, 2001
Structure− activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors
A Belyaev, X Zhang, K Augustyns, AM Lambeir, I De Meester, ...
Journal of medicinal chemistry 42 (6), 1041-1052, 1999
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
D Rojas-Rivera, T Delvaeye, R Roelandt, W Nerinckx, K Augustyns, ...
Cell Death & Differentiation 24 (6), 1100-1110, 2017
Extended structure–activity relationship and pharmacokinetic investigation of (4-quinolinoyl) glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP)
K Jansen, L Heirbaut, R Verkerk, JD Cheng, J Joossens, P Cos, L Maes, ...
Journal of medicinal chemistry 57 (7), 3053-3074, 2014
Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases
P Van der Veken, K Senten, I Kertèsz, I De Meester, AM Lambeir, ...
Journal of medicinal chemistry 48 (6), 1768-1780, 2005
Regulation of intestinal permeability: the role of proteases
H Van Spaendonk, H Ceuleers, L Witters, E Patteet, J Joossens, ...
World journal of gastroenterology 23 (12), 2106, 2017
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells
IMD Bastos, P Grellier, NF Martins, G Cadavid-Restrepo, ...
Biochemical Journal 388 (1), 29-38, 2005
Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold
K Jansen, L Heirbaut, JD Cheng, J Joossens, O Ryabtsova, P Cos, ...
ACS medicinal chemistry letters 4 (5), 491-496, 2013
Inhibitors of the purine salvage pathway: a valuable approach for antiprotozoal chemotherapy?
M Berg, P Van der Veken, A Goeminne, A Haemers, K Augustyns
Current medicinal chemistry 17 (23), 2456-2481, 2010
Natural substrates of dipeptidyl peptidase IV
ID Meester, C Durinx, G Bal, P Proost, S Struyf, F Goossens, K Augustyns, ...
Cellular peptidases in immune functions and diseases 2, 67-87, 2002
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents
K Augustyns, K Amssoms, A Yamani, PK Rajan, A Haemers
Current pharmaceutical design 7 (12), 1117, 2001
Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator
J Joossens, P Van der Veken, AM Lambeir, K Augustyns, A Haemers
Journal of medicinal chemistry 47 (10), 2411-2413, 2004
Prolyl oligopeptidase stimulates the aggregation of α-synuclein
I Brandt, M Gérard, K Sergeant, B Devreese, V Baekelandt, K Augustyns, ...
Peptides 29 (9), 1472-1478, 2008
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability
K Augustyns, F Vandendriessche, A Van Aerschot, R Busson, C Urbanke, ...
Nucleic acids research 20 (18), 4711-4716, 1992
The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases
K Augustyns, PV d Veken, K Senten, A Haemers
Current medicinal chemistry 12 (8), 971-998, 2005
A new approach towards the synthesis of 3-amino-6-(hetero) arylpyridazines based on palladium catalyzed cross-coupling reactions
BUW Maes, GLF Lemiere, R Dommisse, K Augustyns, A Haemers
Tetrahedron 56 (12), 1777-1781, 2000
Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives
I El Sayed, P Van der Veken, K Steert, L Dhooghe, S Hostyn, ...
Journal of medicinal chemistry 52 (9), 2979-2988, 2009
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