Stebėti
Szymon Klossowski
Szymon Klossowski
Nežinomas ryšys
El. paštas nepatvirtintas
Pavadinimas
Cituota
Cituota
Metai
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
S Klossowski, H Miao, K Kempinska, T Wu, T Purohit, EG Kim, ...
The Journal of clinical investigation 130 (2), 981-997, 2020
1602020
Model studies on the first enzyme-catalyzed Ugi reaction
S Kłossowski, B Wiraszka, S Berłożecki, R Ostaszewski
Organic Letters 15 (3), 566-569, 2013
682013
Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma
A Trzeciecka, S Klossowski, M Bajor, R Zagozdzon, P Gaj, A Muchowicz, ...
Oncotarget 7 (2), 1717, 2016
532016
Complexity of blocking bivalent protein–protein interactions: development of a highly potent inhibitor of the menin–mixed-lineage leukemia interaction
D Borkin, S Klossowski, J Pollock, H Miao, BM Linhares, K Kempinska, ...
Journal of medicinal chemistry 61 (11), 4832-4850, 2018
492018
Studies toward novel peptidomimetic inhibitors of thioredoxin–thioredoxin reductase system
S Kłossowski, A Muchowicz, M Firczuk, M Swiech, A Redzej, J Golab, ...
Journal of medicinal chemistry 55 (1), 55-67, 2012
462012
Menin regulates the serine biosynthetic pathway in Ewing sarcoma
LK Svoboda, SSK Teh, S Sud, S Kerk, A Zebolsky, S Treichel, D Thomas, ...
The Journal of pathology 245 (3), 324-336, 2018
432018
Adenanthin targets proteins involved in the regulation of disulphide bonds
A Muchowicz, M Firczuk, J Chlebowska, D Nowis, J Stachura, ...
Biochemical pharmacology 89 (2), 210-216, 2014
412014
Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma
K Kempinska, B Malik, D Borkin, S Klossowski, S Shukla, H Miao, J Wang, ...
Molecular cancer therapeutics 17 (1), 26-38, 2018
342018
Substituted inhibitors of menin-MLL and methods of use
T Wu, L Li, Y Wang, P Ren, J Grembecka, T Cierpicki, S Klossowski, ...
US Patent 10,781,218, 2020
262020
SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress
A Muchowicz, M Firczuk, M Wachowska, M Kujawa, E Jankowska-Steifer, ...
Biochemical Pharmacology 93 (4), 418-427, 2015
262015
Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations
H Miao, EG Kim, D Chen, T Purohit, K Kempinska, J Ropa, S Klossowski, ...
Blood, The Journal of the American Society of Hematology 136 (25), 2958-2963, 2020
232020
Enzymatic Ugi reaction with amines and cyclic imines
A Żądło‐Dobrowolska, S Kłossowski, D Koszelewski, D Paprocki, ...
Chemistry–A European Journal 22 (46), 16684-16689, 2016
222016
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity
DS Rogawski, J Deng, H Li, H Miao, D Borkin, T Purohit, J Song, J Chase, ...
Nature communications 12 (1), 2792, 2021
202021
Methods and compositions for inhibiting the interaction of menin with MLL proteins
J Grembecka, T Cierpicki, D Borkin, J Pollock, L Li, T Wu, J Feng, P Ren, ...
US Patent 10,077,271, 2018
172018
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C
C Carpenter, RJ Sorenson, Y Jin, S Klossowski, T Cierpicki, M Gnegy, ...
Bioorganic & medicinal chemistry 24 (21), 5495-5504, 2016
172016
Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity
W Szymanski, M Zwolinska, S Klossowski, I Młynarczuk-Biały, Ł Biały, ...
Bioorganic & Medicinal Chemistry 22 (5), 1773-1781, 2014
172014
Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules
W Jedwabny, S Kłossowski, T Purohit, T Cierpicki, J Grembecka, ...
MedChemComm 8 (12), 2216-2227, 2017
82017
Chemoenzymatic synthesis and application of a new, easily chiral auxiliary for the synthesis of peptidomimetics via an Ugi reaction
S Klossowski, A Brodzka, M Zysk, R Ostaszewski
Tetrahedron: Asymmetry 25 (5), 435-442, 2014
82014
Enzymatic synergism in the synthesis of β‐keto esters
C Wiśniewska, D Koszelewski, M Zysk, S Kłossowski, A Żądło, A Brodzka, ...
European Journal of Organic Chemistry 2015 (24), 5432-5437, 2015
72015
Ash1l inhibitors and methods of treatment therewith
J Grembecka, T Cierpicki, D Rogawski, D Borkin, S Klossowski, Z Jin, ...
US Patent 11,883,381, 2024
52024
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Straipsniai 1–20