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Ryan G Kruger
Ryan G Kruger
Anagenex
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Cited by
Year
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
MT McCabe, HM Ott, G Ganji, S Korenchuk, C Thompson, GS Van Aller, ...
Nature 492 (7427), 108-112, 2012
18992012
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
W Béguelin, R Popovic, M Teater, Y Jiang, KL Bunting, M Rosen, H Shen, ...
Cancer cell 23 (5), 677-692, 2013
9102013
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8352015
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
MT McCabe, AP Graves, G Ganji, E Diaz, WS Halsey, Y Jiang, ...
Proceedings of the National Academy of Sciences 109 (8), 2989-2994, 2012
5392012
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
E Chan-Penebre, KG Kuplast, CR Majer, PA Boriack-Sjodin, TJ Wigle, ...
Nature chemical biology 11 (6), 432-437, 2015
5362015
A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC
HP Mohammad, KN Smitheman, CD Kamat, D Soong, KE Federowicz, ...
Cancer cell 28 (1), 57-69, 2015
4892015
Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2
SK Verma, X Tian, LV LaFrance, C Duquenne, DP Suarez, KA Newlander, ...
ACS medicinal chemistry letters 3 (12), 1091-1096, 2012
4052012
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
PK Mazur, N Reynoird, P Khatri, PWTC Jansen, AW Wilkinson, S Liu, ...
Nature 510 (7504), 283-287, 2014
3952014
Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation
GG Liou, JC Tanny, RG Kruger, T Walz, D Moazed
Cell 121 (4), 515-527, 2005
3292005
Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss
A Fedoriw, SR Rajapurkar, S O'Brien, SV Gerhart, LH Mitchell, ND Adams, ...
Cancer cell 36 (1), 100-114. e25, 2019
2372019
Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus
BA Frankel, M Bentley, RG Kruger, DG McCafferty
Journal of the American Chemical Society 126 (11), 3404-3405, 2004
2242004
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
GS Van Aller, N Reynoird, O Barbash, M Huddleston, S Liu, AF Zmoos, ...
Epigenetics 7 (4), 340-343, 2012
2072012
Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA
RG Kruger, B Otvos, BA Frankel, M Bentley, P Dostal, DG McCafferty
Biochemistry 43 (6), 1541-1551, 2004
1882004
Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism
BA Frankel, RG Kruger, DE Robinson, NL Kelleher, DG McCafferty
Biochemistry 44 (33), 11188-11200, 2005
1822005
Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing
SV Gerhart, WA Kellner, C Thompson, MB Pappalardi, XP Zhang, ...
Scientific reports 8 (1), 9711, 2018
1672018
Chemistry and biology of the ramoplanin family of peptide antibiotics
DG McCafferty, P Cudic, BA Frankel, S Barkallah, RG Kruger, W Li
Peptide Science: Original Research on Biomolecules 66 (4), 261-284, 2002
1522002
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
CC Bell, KA Fennell, YC Chan, F Rambow, MM Yeung, D Vassiliadis, ...
Nature communications 10 (1), 2723, 2019
1482019
Distinct concentration-dependent effects of the polo-like kinase 1–specific inhibitor GSK461364A, including differential effect on apoptosis
AG Gilmartin, MR Bleam, MC Richter, SG Erskine, RG Kruger, L Madden, ...
Cancer research 69 (17), 6969-6977, 2009
1362009
Synergy and duality in peptide antibiotic mechanisms
DG McCafferty, P Cudic, KY Michael, DC Behenna, R Kruger
Current opinion in chemical biology 3 (6), 672-680, 1999
1361999
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers
P Sabbatini, S Korenchuk, JL Rowand, A Groy, Q Liu, D Leperi, C Atkins, ...
Molecular cancer therapeutics 8 (10), 2811-2820, 2009
1292009
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