| The ensemble nature of allostery HN Motlagh, JO Wrabl, J Li, VJ Hilser Nature 508 (7496), 331-339, 2014 | 1234 | 2014 |
| Allostery in its many disguises: from theory to applications SJ Wodak, E Paci, NV Dokholyan, IN Berezovsky, A Horovitz, J Li, ... Structure 27 (4), 566-578, 2019 | 301 | 2019 |
| Dynamic allostery can drive cold adaptation in enzymes HG Saavedra, JO Wrabl, JA Anderson, J Li, VJ Hilser Nature 558 (7709), 324-328, 2018 | 171 | 2018 |
| Conformational equilibria and intrinsic affinities define integrin activation J Li, Y Su, W Xia, Y Qin, MJ Humphries, D Vestweber, C Cabañas, C Lu, ... The EMBO journal 36 (5), 629-645, 2017 | 144 | 2017 |
| Integrin extension enables ultrasensitive regulation by cytoskeletal force J Li, TA Springer Proceedings of the National Academy of Sciences 114 (18), 4685-4690, 2017 | 142 | 2017 |
| A milieu molecule for TGF-β required for microglia function in the nervous system Y Qin, BS Garrison, W Ma, R Wang, A Jiang, J Li, M Mistry, RT Bronson, ... Cell 174 (1), 156-171. e16, 2018 | 141 | 2018 |
| Relating conformation to function in integrin α5β1 Y Su, W Xia, J Li, T Walz, MJ Humphries, D Vestweber, C Cabañas, C Lu, ... Proceedings of the National Academy of Sciences 113 (27), E3872-E3881, 2016 | 140 | 2016 |
| Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor J Li, JT White, H Saavedra, JO Wrabl, HN Motlagh, K Liu, J Sowers, ... Elife 6, e30688, 2017 | 88 | 2017 |
| Thermodynamic dissection of the intrinsically disordered N-terminal domain of human glucocorticoid receptor J Li, HN Motlagh, C Chakuroff, EB Thompson, VJ Hilser Journal of Biological Chemistry 287 (32), 26777-26787, 2012 | 61 | 2012 |
| Interplay between allostery and intrinsic disorder in an ensemble HN Motlagh, J Li, EB Thompson, VJ Hilser Biochemical Society Transactions 40 (5), 975-980, 2012 | 60 | 2012 |
| Energy landscape differences among integrins establish the framework for understanding activation J Li, TA Springer Journal of Cell Biology 217 (1), 397-412, 2018 | 58 | 2018 |
| The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions ML Hegde, SE Tsutakawa, PM Hegde, LMF Holthauzen, J Li, N Oezguen, ... Journal of molecular biology 425 (13), 2359-2371, 2013 | 49 | 2013 |
| Atypical interactions of integrin αVβ8 with pro-TGF-β1 J Wang, X Dong, B Zhao, J Li, C Lu, TA Springer Proceedings of the National Academy of Sciences 114 (21), E4168-E4174, 2017 | 41 | 2017 |
| Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells J Li, M Xu, Z Yang, A Li, J Dong Cancer Investigation 28 (4), 350-356, 2010 | 39 | 2010 |
| Ensemble allosteric model: energetic frustration within the intrinsically disordered glucocorticoid receptor JT White, J Li, E Grasso, JO Wrabl, VJ Hilser Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 31 | 2018 |
| A general chemical principle for creating closure-stabilizing integrin inhibitors FY Lin, J Li, Y Xie, J Zhu, TTH Nguyen, Y Zhang, J Zhu, TA Springer Cell 185 (19), 3533-3550. e27, 2022 | 21 | 2022 |
| Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state J Li, J Yan, TA Springer Elife 10, e73359, 2021 | 21 | 2021 |
| Strategies for the thermodynamic characterization of linked binding/local folding reactions within the native state: application to the LID domain of adenylate kinase from … TP Schrank, WA Elam, J Li, VJ Hilser Methods in enzymology 492, 253-282, 2011 | 19 | 2011 |
| Specific high affinity interaction of Helicobacter pylori CagL with integrin αVβ6 promotes type IV secretion of CagA into human cells M Buß, N Tegtmeyer, J Schnieder, X Dong, J Li, TA Springer, S Backert, ... The FEBS journal 286 (20), 3980-3997, 2019 | 16 | 2019 |
| Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange JR Anderson, J Li, TA Springer, A Brown Blood, The Journal of the American Society of Hematology 140 (12), 1419-1430, 2022 | 15 | 2022 |
Vincent J. HilserProfessor and Chair, Department of Biology, Johns Hopkins UniversityVerified email at jhu.edu
