Cinzia Tesauro
Cinzia Tesauro
Senior Scientist, VPCIR biosciences aps
Patvirtintas el. paštas
Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement
S Juul, CJF Nielsen, R Labouriau, A Roy, C Tesauro, PW Jensen, ...
ACS nano 6 (12), 10676-10683, 2012
Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity
C Alonso, M Fuertes, E Martín-Encinas, A Selas, G Rubiales, C Tesauro, ...
European Journal of Medicinal Chemistry 149, 225-237, 2018
Real-time label-free direct electronic monitoring of topoisomerase enzyme binding kinetics on graphene
L Zuccaro, C Tesauro, T Kurkina, P Fiorani, HK Yu, BR Knudsen, K Kern, ...
ACS nano 9 (11), 11166-11176, 2015
Interaction between natural compounds and human topoisomerase I
S Castelli, A Coletta, I D’Annessa, P Fiorani, C Tesauro, A Desideri
Biological Chemistry 393 (11), 1327-1340, 2012
Synthesis and biological evaluation of indeno [1, 5] naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity
C Alonso, M Fuertes, M González, G Rubiales, C Tesauro, BR Knudsen, ...
European Journal of Medicinal Chemistry 115, 179-190, 2016
Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I
C Tesauro, P Fiorani, I d'Annessa, G Chillemi, G Turchi, A Desideri
Biochemical Journal 425 (3), 531-539, 2010
Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study
C Tesauro, AK Simonsen, MB Andersen, KW Petersen, EL Kristoffersen, ...
BMC cancer 19, 1-15, 2019
Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant
P Fiorani, C Tesauro, G Mancini, G Chillemi, I D'A; nnessa, G Graziani, ...
Nucleic acids research 37 (20), 6849-6858, 2009
Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin
S Castelli, A Campagna, O Vassallo, C Tesauro, P Fiorani, P Tagliatesta, ...
Archives of biochemistry and biophysics 486 (2), 103-110, 2009
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
C Tesauro, B Morozzo della Rocca, A Ottaviani, A Coletta, L Zuccaro, ...
Molecular cancer 12, 1-13, 2013
Synthesis of novel hybrid quinolino [4, 3-b][1, 5] naphthyridines and quinolino [4, 3-b][1, 5] naphthyridin-6 (5H)-one derivatives and biological evaluation as topoisomerase I …
E Martín-Encinas, A Selas, C Tesauro, G Rubiales, BR Knudsen, ...
European Journal of Medicinal Chemistry 195, 112292, 2020
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I
A Roy, C Tesauro, R Frøhlich, MS Hede, MJ Nielsen, E Kjeldsen, ...
PloS one 9 (6), e99628, 2014
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation
I D'Annessa, C Tesauro, Z Wang, B Arnò, L Zuccaro, P Fiorani, A Desideri
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (12), 2712-2721, 2013
Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification
C Tesauro, S Juul, B Arnò, CJF Nielsen, P Fiorani, RF Frøhlich, ...
2012 Annual International Conference of the IEEE Engineering in Medicine and …, 2012
Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant
B Arnò, I D’Annessa, C Tesauro, L Zuccaro, A Ottaviani, B Knudsen, ...
PLoS One 8 (7), e68404, 2013
Role of Flexibility in Protein‐DNA‐Drug Recognition: The Case of Asp677Gly‐Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
I D′ Annessa, C Tesauro, P Fiorani, G Chillemi, S Castelli, O Vassallo, ...
Journal of amino acids 2012 (1), 206083, 2012
Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study
MB Andersen, C Tesauro, M Gonzalez, EL Kristoffersen, C Alonso, ...
Nanoscale 9 (5), 1886-1895, 2017
Genetic and molecular characterization of the immortalized murine hepatic stellate cell line GRX
SK Schröder, HM Schüler, KV Petersen, C Tesauro, BR Knudsen, ...
Cells 11 (9), 1504, 2022
Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation
Z Wang, I D'Annessa, C Tesauro, S Croce, A Ottaviani, P Fiorani, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (8), 860-868, 2015
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
JG Keller, KM Hymøller, ME Thorsager, NY Hansen, JU Erlandsen, ...
Nucleic Acids Research 50 (11), 6332-6342, 2022
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Straipsniai 1–20