Stebėti
Cinzia Tesauro
Cinzia Tesauro
Senior Scientist, VPCIR biosciences aps
Patvirtintas el. paštas mb.au.dk
Pavadinimas
Cituota
Cituota
Metai
Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement
S Juul, CJF Nielsen, R Labouriau, A Roy, C Tesauro, PW Jensen, ...
ACS nano 6 (12), 10676-10683, 2012
982012
Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity
C Alonso, M Fuertes, E Martín-Encinas, A Selas, G Rubiales, C Tesauro, ...
European Journal of Medicinal Chemistry 149, 225-237, 2018
702018
Real-time label-free direct electronic monitoring of topoisomerase enzyme binding kinetics on graphene
L Zuccaro, C Tesauro, T Kurkina, P Fiorani, HK Yu, BR Knudsen, K Kern, ...
ACS nano 9 (11), 11166-11176, 2015
592015
Interaction between natural compounds and human topoisomerase I
S Castelli, A Coletta, I D’Annessa, P Fiorani, C Tesauro, A Desideri
Biological Chemistry 393 (11), 1327-1340, 2012
572012
Synthesis and biological evaluation of indeno [1, 5] naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity
C Alonso, M Fuertes, M González, G Rubiales, C Tesauro, BR Knudsen, ...
European Journal of Medicinal Chemistry 115, 179-190, 2016
542016
Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I
C Tesauro, P Fiorani, I d'Annessa, G Chillemi, G Turchi, A Desideri
Biochemical Journal 425 (3), 531-539, 2010
532010
Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study
C Tesauro, AK Simonsen, MB Andersen, KW Petersen, EL Kristoffersen, ...
BMC cancer 19, 1-15, 2019
462019
Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant
P Fiorani, C Tesauro, G Mancini, G Chillemi, I D'A; nnessa, G Graziani, ...
Nucleic acids research 37 (20), 6849-6858, 2009
362009
Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin
S Castelli, A Campagna, O Vassallo, C Tesauro, P Fiorani, P Tagliatesta, ...
Archives of biochemistry and biophysics 486 (2), 103-110, 2009
352009
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
C Tesauro, B Morozzo della Rocca, A Ottaviani, A Coletta, L Zuccaro, ...
Molecular cancer 12, 1-13, 2013
342013
Synthesis of novel hybrid quinolino [4, 3-b][1, 5] naphthyridines and quinolino [4, 3-b][1, 5] naphthyridin-6 (5H)-one derivatives and biological evaluation as topoisomerase I …
E Martín-Encinas, A Selas, C Tesauro, G Rubiales, BR Knudsen, ...
European Journal of Medicinal Chemistry 195, 112292, 2020
252020
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I
A Roy, C Tesauro, R Frøhlich, MS Hede, MJ Nielsen, E Kjeldsen, ...
PloS one 9 (6), e99628, 2014
252014
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation
I D'Annessa, C Tesauro, Z Wang, B Arnò, L Zuccaro, P Fiorani, A Desideri
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (12), 2712-2721, 2013
172013
Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification
C Tesauro, S Juul, B Arnò, CJF Nielsen, P Fiorani, RF Frøhlich, ...
2012 Annual International Conference of the IEEE Engineering in Medicine and …, 2012
162012
Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant
B Arnò, I D’Annessa, C Tesauro, L Zuccaro, A Ottaviani, B Knudsen, ...
PLoS One 8 (7), e68404, 2013
152013
Role of Flexibility in Protein‐DNA‐Drug Recognition: The Case of Asp677Gly‐Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
I D′ Annessa, C Tesauro, P Fiorani, G Chillemi, S Castelli, O Vassallo, ...
Journal of amino acids 2012 (1), 206083, 2012
152012
Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study
MB Andersen, C Tesauro, M Gonzalez, EL Kristoffersen, C Alonso, ...
Nanoscale 9 (5), 1886-1895, 2017
142017
Genetic and molecular characterization of the immortalized murine hepatic stellate cell line GRX
SK Schröder, HM Schüler, KV Petersen, C Tesauro, BR Knudsen, ...
Cells 11 (9), 1504, 2022
132022
Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation
Z Wang, I D'Annessa, C Tesauro, S Croce, A Ottaviani, P Fiorani, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (8), 860-868, 2015
132015
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
JG Keller, KM Hymøller, ME Thorsager, NY Hansen, JU Erlandsen, ...
Nucleic Acids Research 50 (11), 6332-6342, 2022
122022
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