Ernesto Freire
Cited by
Cited by
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
PD Kwong, ML Doyle, DJ Casper, C Cicala, SA Leavitt, S Majeed, ...
Nature 420 (6916), 678-682, 2002
Direct measurement of protein binding energetics by isothermal titration calorimetry
S Leavitt, E Freire
Current opinion in structural biology 11 (5), 560-566, 2001
Thermodynamics of structural stability and cooperative folding behavior in proteins
KP Murphy, E Freire
Advances in protein chemistry 43, 313-361, 1992
Isothermal titration calorimetry
E Freire, OL Mayorga, M Straume
Analytical chemistry 62 (18), 950A-959A, 1990
The heat capacity of proteins
J Gomez, VJ Hilser, D Xie, E Freire
Proteins: Structure, Function, and Bioinformatics 22 (4), 404-412, 1995
Do enthalpy and entropy distinguish first in class from best in class?
E Freire
Drug discovery today 13 (19-20), 869-874, 2008
Statistical mechanical deconvolution of thermal transitions in macromolecules. I. Theory and application to homogeneous systems
E Freire, RL Biltonen
Biopolymers: Original Research on Biomolecules 17 (2), 463-479, 1978
Adding calorimetric data to decision making in lead discovery: a hot tip
JE Ladbury, G Klebe, E Freire
Nature reviews Drug discovery 9 (1), 23-27, 2010
Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo
Q Xu, LM Ensign, NJ Boylan, A Schon, X Gong, JC Yang, NW Lamb, ...
ACS nano 9 (9), 9217-9227, 2015
The magnitude of the backbone conformational entropy change in protein folding
JA D'aquino, J Gómez, VJ Hilser, KH Lee, LM Amzel, E Freire
Proteins: Structure, Function, and Bioinformatics 25 (2), 143-156, 1996
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
Y Do Kwon, M Pancera, P Acharya, IS Georgiev, ET Crooks, J Gorman, ...
Nature structural & molecular biology 22 (7), 522-531, 2015
Forces and factors that contribute to the structural stability of membrane proteins
T Haltia, E Freire
Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes 1241 (2), 295-322, 1995
Isothermal titration calorimetry to determine association constants for high-affinity ligands
A Velazquez-Campoy, E Freire
Nature protocols 1 (1), 186-191, 2006
Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors
VJ Hilser, E Freire
Journal of molecular biology 262 (5), 756-772, 1996
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins
Z Si, N Madani, JM Cox, JJ Chruma, JC Klein, A Schön, N Phan, L Wang, ...
Proceedings of the National Academy of Sciences 101 (14), 5036-5041, 2004
Calorimetrically determined dynamics of complex unfolding transitions in proteins
E Freire, WW Osdol, OL Mayorga, JM Sanchez-Ruiz
Annual review of biophysics and biophysical chemistry 19 (1), 159-188, 1990
Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin
J Gómez, E Freire
Journal of molecular biology 252 (3), 337-350, 1995
Estimation of changes in side chain configurational entropy in binding and folding: general methods and application to helix formation
KH Lee, D Xie, E Freire, LM Amzel
Proteins: Structure, Function, and Bioinformatics 20 (1), 68-84, 1994
Differential scanning calorimetry
E Freire
Protein stability and folding: Theory and practice, 191-218, 1995
Isothermal titration calorimetry
A Velázquez‐Campoy, H Ohtaka, A Nezami, S Muzammil, E Freire
Current protocols in cell biology 23 (1), 17.8. 1-17.8. 24, 2004
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