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| Direct measurement of protein binding energetics by isothermal titration calorimetry S Leavitt, E Freire Current opinion in structural biology 11 (5), 560-566, 2001 | 932 | 2001 |
| Thermodynamics of structural stability and cooperative folding behavior in proteins KP Murphy, E Freire Advances in protein chemistry 43, 313-361, 1992 | 837 | 1992 |
| Isothermal titration calorimetry E Freire, OL Mayorga, M Straume Analytical chemistry 62 (18), 950A-959A, 1990 | 759 | 1990 |
| The heat capacity of proteins J Gomez, VJ Hilser, D Xie, E Freire Proteins: Structure, Function, and Bioinformatics 22 (4), 404-412, 1995 | 530 | 1995 |
| Do enthalpy and entropy distinguish first in class from best in class? E Freire Drug discovery today 13 (19-20), 869-874, 2008 | 508 | 2008 |
| Statistical mechanical deconvolution of thermal transitions in macromolecules. I. Theory and application to homogeneous systems E Freire, RL Biltonen Biopolymers: Original Research on Biomolecules 17 (2), 463-479, 1978 | 470 | 1978 |
| Adding calorimetric data to decision making in lead discovery: a hot tip JE Ladbury, G Klebe, E Freire Nature reviews Drug discovery 9 (1), 23-27, 2010 | 453 | 2010 |
| Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo Q Xu, LM Ensign, NJ Boylan, A Schon, X Gong, JC Yang, NW Lamb, ... ACS nano 9 (9), 9217-9227, 2015 | 432 | 2015 |
| The magnitude of the backbone conformational entropy change in protein folding JA D'aquino, J Gómez, VJ Hilser, KH Lee, LM Amzel, E Freire Proteins: Structure, Function, and Bioinformatics 25 (2), 143-156, 1996 | 355 | 1996 |
| Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env Y Do Kwon, M Pancera, P Acharya, IS Georgiev, ET Crooks, J Gorman, ... Nature structural & molecular biology 22 (7), 522-531, 2015 | 339 | 2015 |
| Forces and factors that contribute to the structural stability of membrane proteins T Haltia, E Freire Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes 1241 (2), 295-322, 1995 | 329 | 1995 |
| Isothermal titration calorimetry to determine association constants for high-affinity ligands A Velazquez-Campoy, E Freire Nature protocols 1 (1), 186-191, 2006 | 320 | 2006 |
| Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors VJ Hilser, E Freire Journal of molecular biology 262 (5), 756-772, 1996 | 314 | 1996 |
| Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins Z Si, N Madani, JM Cox, JJ Chruma, JC Klein, A Schön, N Phan, L Wang, ... Proceedings of the National Academy of Sciences 101 (14), 5036-5041, 2004 | 310 | 2004 |
| Calorimetrically determined dynamics of complex unfolding transitions in proteins E Freire, WW Osdol, OL Mayorga, JM Sanchez-Ruiz Annual review of biophysics and biophysical chemistry 19 (1), 159-188, 1990 | 302 | 1990 |
| Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin J Gómez, E Freire Journal of molecular biology 252 (3), 337-350, 1995 | 297 | 1995 |
| Estimation of changes in side chain configurational entropy in binding and folding: general methods and application to helix formation KH Lee, D Xie, E Freire, LM Amzel Proteins: Structure, Function, and Bioinformatics 20 (1), 68-84, 1994 | 281 | 1994 |
| Differential scanning calorimetry E Freire Protein stability and folding: Theory and practice, 191-218, 1995 | 280 | 1995 |
| Isothermal titration calorimetry A Velázquez‐Campoy, H Ohtaka, A Nezami, S Muzammil, E Freire Current protocols in cell biology 23 (1), 17.8. 1-17.8. 24, 2004 | 275 | 2004 |
Adrian Velazquez-CampoyInstitute BIFI - University of ZaragozaVerified email at unizar.es
