John E Burke
John E Burke
Professor of Biochemistry and Microbiology, University of Victoria
Verified email at - Homepage
Cited by
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Accurate prediction of protein structures and interactions using a three-track neural network
M Baek, F DiMaio, I Anishchenko, J Dauparas, S Ovchinnikov, GR Lee, ...
Science 373 (6557), 871-876, 2021
Phospholipase A2 structure/function, mechanism, and signaling1
JE Burke, EA Dennis
Journal of lipid research 50, S237-S242, 2009
Phospholipase A2 Biochemistry
JE Burke, EA Dennis
Cardiovascular drugs and therapy 23, 49-59, 2009
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ...
Nature methods 16 (7), 595-602, 2019
Structural basis for activation and inhibition of class I phosphoinositide 3-kinases
O Vadas, JE Burke, X Zhang, A Berndt, RL Williams
Science signaling 4 (195), re2-re2, 2011
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
JE Burke, O Perisic, GR Masson, O Vadas, RL Williams
Proceedings of the National Academy of Sciences, 2012
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ...
Nature 538 (7625), 344-349, 2016
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
K Rostislavleva, N Soler, Y Ohashi, L Zhang, E Pardon, JE Burke, ...
Science 350 (6257), aac7365, 2015
Structural basis for regulation of phosphoinositide kinases and their involvement in human disease
JE Burke
Molecular cell 71 (5), 653-673, 2018
Synergy in activating class I PI3Ks
JE Burke, RL Williams
Trends in biochemical sciences 40 (2), 88-100, 2015
G protein–coupled receptor–mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness
HA Dbouk, O Vadas, A Shymanets, JE Burke, RS Salamon, BD Khalil, ...
Science signaling 5 (253), ra89-ra89, 2012
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi
G D’Angelo, T Uemura, CC Chuang, E Polishchuk, M Santoro, ...
Nature 501 (7465), 116-120, 2013
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)
O Vadas, HA Dbouk, A Shymanets, O Perisic, JE Burke, WF Abi Saab, ...
Proceedings of the National Academy of Sciences 110 (47), 18862-18867, 2013
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne
TET Mevissen, Y Kulathu, MPC Mulder, PP Geurink, SL Maslen, M Gersch, ...
Nature 538 (7625), 402-405, 2016
An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery
GR Masson, ML Jenkins, JE Burke
Expert opinion on drug discovery 12 (10), 981-994, 2017
Novel roles of phosphoinositides in signaling, lipid transport, and disease
GRV Hammond, JE Burke
Current Opinion in Cell Biology 63, 57-67, 2020
Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors
JE Burke, AJ Inglis, O Perisic, GR Masson, SH McLaughlin, F Rutaganira, ...
Science 344 (6187), 1035-1038, 2014
Dynamics of the Phosphoinositide 3-Kinase p110 [delta] Interaction with p85 [alpha] and Membranes Reveals Aspects of Regulation Distinct from p110 [alpha]
JE Burke, O Vadas, A Berndt, T Finegan, O Perisic, RL Williams
Structure 19 (8), 1127-1137, 2011
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1
GL Dornan, BD Siempelkamp, ML Jenkins, O Vadas, CL Lucas, JE Burke
Proceedings of the National Academy of Sciences 114 (8), 1982-1987, 2017
Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2
G Kokotos, YH Hsu, JE Burke, C Baskakis, CG Kokotos, V Magrioti, ...
Journal of medicinal chemistry 53 (9), 3602-3610, 2010
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