| 2', 5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'', 2''-oxathiole-2'', 2'-dioxide) pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human … J Balzarini, MJ Perez-Perez, A San-Felix, D Schols, CF Perno, ... Proceedings of the National Academy of Sciences 89 (10), 4392-4396, 1992 | 252 | 1992 |
| HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase J Balzarini, A Karlsson, MJ Perez-Perez, L Vrang, J Walbers, H Zhang, ... Virology 192 (1), 246-253, 1993 | 201 | 1993 |
| 3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-. beta … MJ Camarasa, MJ Perez-Perez, A San-Felix, J Balzarini, E De Clercq Journal of medicinal chemistry 35 (15), 2721-2727, 1992 | 167 | 1992 |
| Blocking blood flow to solid tumors by destabilizing tubulin: an approach to targeting tumor growth MJ Pérez-Pérez, EM Priego, O Bueno, MS Martins, MD Canela, S Liekens Journal of medicinal chemistry 59 (19), 8685-8711, 2016 | 163 | 2016 |
| Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2', 5'-bis-O-(tert … J Balzarini, MJ Pérez-Pérez, A San-Felix, MJ Camarasa, IC Bathurst, ... Journal of Biological Chemistry 267 (17), 11831-11838, 1992 | 144 | 1992 |
| Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does … J Balzarini, A Karlsson, MJ Pérez-Pérez, MJ Camarasa, WG Tarpley, ... Journal of Virology 67 (9), 5353-5359, 1993 | 131 | 1993 |
| TSAO analogs. Stereospecific synthesis and anti-HIV-1 activity of 1-[2', 5'-bis-O-(tert-butyldimethylsilyl)-. beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'', 2''-oxathiole … MJ Perez-Perez, A San-Felix, J Balzarini, E De Clercq, MJ Camarasa Journal of medicinal chemistry 35 (16), 2988-2995, 1992 | 122 | 1992 |
| Design, Synthesis, and Enzymatic Evaluation of Multisubstrate Analogue Inhibitors of Escherichia coli Thymidine Phosphorylase A Esteban-Gamboa, J Balzarini, R Esnouf, E De Clercq, MJ Camarasa, ... Journal of medicinal chemistry 43 (5), 971-983, 2000 | 115 | 2000 |
| Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2', 5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'', 2 … J Balzarini, A Karlsson, AM Vandamme, MJ Pérez-Pérez, H Zhang, ... Proceedings of the National Academy of Sciences 90 (15), 6952-6956, 1993 | 110 | 1993 |
| The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection L Delang, C Li, A Tas, G Quérat, IC Albulescu, T De Burghgraeve, ... Scientific Reports 6 (1), 31819, 2016 | 104 | 2016 |
| Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy S Liekens, A Bronckaers, MJ Pérez-Pérez, J Balzarini Biochemical pharmacology 74 (11), 1555-1567, 2007 | 95 | 2007 |
| 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase J Balzarini, AE Gamboa, R Esnouf, S Liekens, J Neyts, E De Clercq, ... FEBS letters 438 (1-2), 91-95, 1998 | 95 | 1998 |
| Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes? MJ Camarasa, S Velázquez, A San-Félix, MJ Pérez-Pérez, F Gago Antiviral research 71 (2-3), 260-267, 2006 | 88 | 2006 |
| Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus J Balzarini, A Karlsson, MJ Pérez-Pérez, MJ Camarasa, E De Clercq Virology 196 (2), 576-585, 1993 | 86 | 1993 |
| Identification of a Putative Binding Site for [2‘,5‘-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]-3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide … F Rodríguez-Barrios, C Pérez, E Lobatón, S Velázquez, C Chamorro, ... Journal of Medicinal Chemistry 44 (12), 1853-1865, 2001 | 83 | 2001 |
| Identification of [1,2,3]Triazolo[4,5-d]pyrimidin-7(6H)-ones as Novel Inhibitors of Chikungunya Virus Replication A Gigante, MD Canela, L Delang, EM Priego, MJ Camarasa, G Querat, ... Journal of Medicinal Chemistry 57 (10), 4000-4008, 2014 | 79 | 2014 |
| The nucleoside derivative 5′-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action S Liekens, AI Hernández, D Ribatti, E De Clercq, MJ Camarasa, ... Journal of Biological Chemistry 279 (28), 29598-29605, 2004 | 74 | 2004 |
| Pyrido[2,1-f]purine-2,4-dione Derivatives as a Novel Class of Highly Potent Human A3 Adenosine Receptor Antagonists EM Priego, J von Frijtag Drabbe Kuenzel, AP IJzerman, MJ Camarasa, ... Journal of medicinal chemistry 45 (16), 3337-3344, 2002 | 73 | 2002 |
| Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with … J Balzarini, MJ Perez-Perez, S Velazquez, A San-Felix, MJ Camarasa, ... Proceedings of the National Academy of Sciences 92 (12), 5470-5474, 1995 | 73 | 1995 |
| Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications MJ Pérez-Pérez, EM Priego, AI Hernández, MJ Camarasa, J Balzarini, ... Mini reviews in medicinal chemistry 5 (12), 1113-1123, 2005 | 72 | 2005 |
