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Adrian Velazquez-Campoy
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Isothermal titration calorimetry to determine association constants for high-affinity ligands
A Velazquez-Campoy, E Freire
Nature Protocols 1 (1), 186, 2006
3442006
Isothermal titration calorimetry
A Velázquez‐Campoy, H Ohtaka, A Nezami, S Muzammil, E Freire
Current Protocols in Cell Biology, 17.8.1-17.8.24, 2004
3102004
ITC in the post-genomic era…? Priceless
AV Campoy, E Freire
Biophysical Chemistry 115 (2), 115-124, 2005
2802005
Characterization of protein-protein interactions by isothermal titration calorimetry
A Velazquez-Campoy, SA Leavitt, E Freire
Methods in Molecular Biology 261, 35-54, 2004
2702004
Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro
U Bacha, J Barrila, A Velazquez-Campoy, SA Leavitt, E Freire
Biochemistry 43 (17), 4906-4912, 2004
2682004
Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening
O Abian, D Ortega-Alarcon, A Jimenez-Alesanco, L Ceballos-Laita, ...
International Journal of Biological Macromolecules 164, 1693-1703, 2020
2552020
The binding energetics of first-and second-generation HIV-1 protease inhibitors: implications for drug design
A Velazquez-Campoy, Y Kiso, E Freire
Archives of biochemistry and biophysics 390 (2), 169-175, 2001
2122001
Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes
A Velazquez-Campoy, MJ Todd, S Vega, E Freire
Proceedings of the National Academy of Sciences 98 (11), 6062-6067, 2001
1942001
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, ...
The Journal of Clinical Investigation 118 (8), 2858, 2008
1912008
Isothermal titration calorimetry: general formalism using binding polynomials
E Freire, A Schön, A Velazquez‐Campoy
Methods in Enzymology 455, 127-155, 2009
1892009
HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity
A Velazquez-Campoy, MJ Todd, E Freire
Biochemistry 39 (9), 2201-2207, 2000
1692000
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
R Sant'Anna, P Gallego, LZ Robinson, A Pereira-Henriques, N Ferreira, ...
Nature Communications 7, 10787, 2016
1632016
Overcoming drug resistance in HIV‐1 chemotherapy: the binding thermodynamics of Amprenavir and TMC‐126 to wild‐type and drug‐resistant mutants of the HIV‐1 protease
H Ohtaka, A Velázquez‐Campoy, D Xie, E Freire
Protein Science 11 (8), 1908-1916, 2002
1602002
Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant
MJ Todd, I Luque, A Velázquez-Campoy, E Freire
Biochemistry 39 (39), 11876-11883, 2000
1552000
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
JL Neira, J Bintz, M Arruebo, B Rizzuti, T Bonacci, S Vega, A Lanas, ...
Scientific Reports 7, 39732, 2017
1302017
Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes
A Velazquez-Campoy, S Vega, E Freire
Biochemistry 41 (27), 8613-8619, 2002
1212002
Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor
A Velazquez-Campoy, I Luque, MJ Todd, M Milutinovich, Y Kiso, E Freire
Protein Science 9 (9), 1801-1809, 2000
1192000
Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions
I Moukadiri, S Prado, J Piera, A Velázquez-Campoy, GR Björk, ...
Nucleic Acids Research 37 (21), 7177-7193, 2009
1142009
Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
CA Elena-Real, A Díaz-Quintana, K González-Arzola, ...
Cell Death & Disease 9 (3), 365, 2018
1082018
Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets
H Ohtaka, S Muzammil, A Schön, A Velazquez-Campoy, S Vega, E Freire
The International Journal of Biochemistry & Cell Biology 36 (9), 1787-1799, 2004
972004
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