Christoph Klenk, MD PhD
Christoph Klenk, MD PhD
Rudolf Buchheim Institute of Pharmacology, University of Giessen
Verified email at - Homepage
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Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli
P Egloff, M Hillenbrand, C Klenk, A Batyuk, P Heine, S Balada, ...
Proceedings of the National Academy of Sciences 111 (6), E655-E662, 2014
Modification of nonstructural protein 1 of influenza A virus by SUMO1
K Xu, C Klenk, B Liu, B Keiner, J Cheng, BJ Zheng, L Li, Q Han, C Wang, ...
Journal of virology 85 (2), 1086-1098, 2011
High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist
J Ehrenmann, J Schöppe, C Klenk, M Rappas, L Kummer, AS Doré, ...
Nature structural & molecular biology 25 (12), 1086-1092, 2018
Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues
A Lupp, C Klenk, C Röcken, M Evert, C Mawrin, S Schulz
European journal of endocrinology 162 (5), 979-986, 2010
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs
M Zhang, M Gui, ZF Wang, C Gorgulla, JJ Yu, H Wu, ZJ Sun, C Klenk, ...
Nature structural & molecular biology 28 (3), 258-267, 2021
SUMO-1 controls the protein stability and the biological function of phosducin
C Klenk, J Humrich, U Quitterer, MJ Lohse
Journal of biological chemistry 281 (13), 8357-8364, 2006
Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth
Q Han, C Chang, L Li, C Klenk, J Cheng, Y Chen, N Xia, Y Shu, Z Chen, ...
Journal of virology 88 (16), 9379-9390, 2014
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
J Schöppe, J Ehrenmann, C Klenk, P Rucktooa, M Schütz, AS Doré, ...
Nature communications 10 (1), 17, 2019
Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts
M Schütz, J Schöppe, E Sedlák, M Hillenbrand, G Nagy-Davidescu, ...
Scientific reports 6 (1), 21508, 2016
Regulation of fusion activity by the cytoplasmic domain of a paramyxovirus F protein
S Tong, M Li, A Vincent, RW Compans, E Fritsch, R Beier, C Klenk, ...
Virology 301 (2), 322-333, 2002
Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores
A Zürn, C Klenk, U Zabel, S Reiner, MJ Lohse, C Hoffmann
Bioconjugate chemistry 21 (5), 853-859, 2010
Formation of a ternary complex among NHERF1, β-arrestin, and parathyroid hormone receptor
C Klenk, T Vetter, A Zürn, JP Vilardaga, PA Friedman, B Wang, MJ Lohse
Journal of biological chemistry 285 (39), 30355-30362, 2010
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
M Deluigi, A Klipp, C Klenk, L Merklinger, SA Eberle, L Morstein, P Heine, ...
Science Advances 7 (5), eabe5504, 2021
A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution
C Klenk, J Ehrenmann, M Schütz, A Plückthun
Scientific reports 6 (1), 21294, 2016
Generation of fluorogen-activating designed ankyrin repeat proteins (FADAs) as versatile sensor tools
M Schütz, A Batyuk, C Klenk, L Kummer, S De Picciotto, B Gülbakan, ...
Journal of molecular biology 428 (6), 1272-1289, 2016
G proteins in reverse mode: receptor-mediated GTP release inhibits G protein and effector function
LG Hommers, C Klenk, C Dees, M Bünemann
Journal of biological chemistry 285 (11), 8227-8233, 2010
Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1
C Klenk, S Schulz, D Calebiro, MJ Lohse
Journal of biological chemistry 285 (12), 8665-8674, 2010
Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition
M Deluigi, L Morstein, M Schuster, C Klenk, L Merklinger, RR Cridge, ...
Nature communications 13 (1), 382, 2022
Blocking them all: β-arrestins inhibit cellular signaling
MJ Lohse, C Klenk
Molecular cell 31 (5), 619-621, 2008
Engineering of challenging G protein-coupled receptors for structure determination and biophysical studies
Y Waltenspühl, J Ehrenmann, C Klenk, A Plückthun
Molecules 26 (5), 1465, 2021
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