Eric S Fischer
Eric S Fischer
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
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Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
ES Fischer, K Böhm, JR Lydeard, H Yang, MB Stadler, S Cavadini, ...
Nature 512 (7512), 49-53, 2014
Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
G Petzold, ES Fischer, NH Thomä
Nature 532 (7597), 127-130, 2016
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
The molecular basis of CRL4 DDB2/CSA ubiquitin ligase architecture, targeting, and activation
ES Fischer, A Scrima, K Böhm, S Matsumoto, GM Lingaraju, M Faty, ...
Cell 147 (5), 1024-1039, 2011
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
CM Olson, B Jiang, MA Erb, Y Liang, ZM Doctor, Z Zhang, T Zhang, ...
Nature chemical biology 14 (2), 163-170, 2018
A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader
HT Huang, D Dobrovolsky, J Paulk, G Yang, EL Weisberg, ZM Doctor, ...
Cell chemical biology 25 (1), 88-99. e6, 2018
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome
KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ...
Elife 7, e38430, 2018
Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance
W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ...
Cell 174 (2), 300-311. e11, 2018
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
M Słabicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, ...
Nature 585 (7824), 293-297, 2020
Crystal structure of the human COP9 signalosome
GM Lingaraju, RD Bunker, S Cavadini, D Hess, U Hassiepen, M Renatus, ...
Nature 512 (7513), 161-165, 2014
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ...
eLife 8, e45457, 2019
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ...
Cell Chemical Biology 27 (1), 19-31. e6, 2020
Development of dual and selective degraders of cyclin‐dependent kinases 4 and 6
B Jiang, ES Wang, KA Donovan, Y Liang, ES Fischer, T Zhang, NS Gray
Angewandte Chemie International Edition 58 (19), 6321-6326, 2019
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ...
Cell chemical biology 26 (2), 300-306. e9, 2019
Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome
S Cavadini, ES Fischer, RD Bunker, A Potenza, GM Lingaraju, KN Goldie, ...
Nature 531 (7596), 598-603, 2016
Chemically induced degradation of anaplastic lymphoma kinase (ALK)
CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ...
Journal of medicinal chemistry 61 (9), 4249-4255, 2018
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development
KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ...
Cell 183 (6), 1714-1731. e10, 2020
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, ...
Molecular Cell 81 (16), 3323-3338. e14, 2021
Small-molecule-induced polymerization triggers degradation of BCL6
M Słabicki, H Yoon, J Koeppel, L Nitsch, SS Roy Burman, C Di Genua, ...
Nature 588 (7836), 164-168, 2020
Humoral signatures of protective and pathological SARS-CoV-2 infection in children
YC Bartsch, C Wang, T Zohar, S Fischinger, C Atyeo, JS Burke, J Kang, ...
Nature medicine 27 (3), 454-462, 2021
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