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Qiaolin Deng
Qiaolin Deng
Structural Chemistry, Merck & Co.
Verified email at merck.com
Title
Cited by
Cited by
Year
An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution
A Heine, EA Stura, JT Yli-Kauhaluoma, C Gao, Q Deng, BR Beno, ...
Science 279 (5358), 1934-1940, 1998
1721998
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template
J Xu, Q Deng, J Chen, KN Houk, J Bartek, D Hilvert, IA Wilson
Science 286 (5448), 2345-2348, 1999
1481999
A single point mutation in ecdysone receptor leads to increased ligand specificity: Implication for gene switch applications
MB Kumar, T Fujimoto, DW Potter, Q Deng, SR Palli
Proceedings of the National Academy of Sciences 99 (23), 14710-14715, 2002
1132002
Benzannulation reactions of Fischer carbene complexes for the synthesis of indolocarbazoles
CA Merlic, Y You, DM McInnes, AL Zechman, MM Miller, Q Deng
Tetrahedron 57 (24), 5199-5212, 2001
972001
CETP inhibitors
A Ali, JM Napolitano, Q Deng, Z Lu, PJ Sinclair, GE Taylor, CF Thompson, ...
US Patent 7,652,049, 2010
692010
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats
HC Shen, FX Ding, Q Deng, LC Wilsie, ML Krsmanovic, AK Taggart, ...
Journal of medicinal chemistry 52 (8), 2587-2602, 2009
682009
CETP inhibitors
A Ali, JM Napolitano, Q Deng, Z Lu, PJ Sinclair, GE Taylor, CF Thompson, ...
US Patent 7,652,049, 2010
672010
Shape Complementarity, Binding‐Site Dynamics, and Transition State Stabilization: A Theoretical Study of Diels–Alder Catalysis by Antibody 1E9
J Chen, Q Deng, R Wang, KN Houk, D Hilvert
ChemBioChem 1 (4), 255-261, 2000
652000
CETP inhibitors
A Ali, JM Napolitano, Q Deng, Z Lu, PJ Sinclair, GE Taylor, CF Thompson, ...
US Patent 7,652,049, 2010
642010
CETP inhibitors
A Ali, JM Napolitano, Q Deng, Z Lu, PJ Sinclair, GE Taylor, CF Thompson, ...
US Patent 7,652,049, 2010
642010
CETP inhibitors
A Ali, JM Napolitano, Q Deng, Z Lu, PJ Sinclair, GE Taylor, CF Thompson, ...
US Patent 7,652,049, 2010
642010
1-benzyl-4-[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl) biphenyl-2-yl] imidazolidin-2-one; cholesteryl ester transfer protein inhibitor; raising HDL-cholesterol …
A Ali, JM Napolitano, Q Deng, Z Lu, PJ Sinclair, GE Taylor, CF Thompson, ...
US Patent 7,652,049, 2010
64*2010
Novel 3, 4-dihydroquinolin-2 (1H)-one inhibitors of human glycogen phosphorylase a
KG Rosauer, AK Ogawa, CA Willoughby, KP Ellsworth, WM Geissler, ...
Bioorganic & Medicinal Chemistry Letters 13 (24), 4385-4388, 2003
552003
Transition structures of the ene reactions of cyclopropene
Q Deng, BE Thomas, KN Houk, P Dowd
Journal of the American Chemical Society 119 (29), 6902-6908, 1997
531997
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors
HC Shen, FX Ding, Q Deng, S Xu, X Tong, X Zhang, Y Chen, G Zhou, ...
Bioorganic & medicinal chemistry letters 19 (19), 5716-5721, 2009
502009
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor
HC Shen, FX Ding, S Luell, MJ Forrest, E Carballo-Jane, KK Wu, TJ Wu, ...
Journal of medicinal chemistry 50 (25), 6303-6306, 2007
502007
Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis …
Q Deng, JA Clemas, G Chrebet, P Fischer, JJ Hale, Z Li, SG Mills, ...
Molecular pharmacology 71 (3), 724-735, 2007
482007
A new class of glycogen phosphorylase inhibitors
Z Lu, J Bohn, R Bergeron, Q Deng, KP Ellsworth, WM Geissler, G Harris, ...
Bioorganic & medicinal chemistry letters 13 (22), 4125-4128, 2003
482003
Binding site analysis of c-Myb: screening of potential binding sites by using the mutation matrix derived from systematic binding affinity measurements
QL Deng, S Ishii, A Sarai
Nucleic acids research 24 (4), 766-774, 1996
451996
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement
HC Shen, FX Ding, S Wang, Q Deng, X Zhang, Y Chen, G Zhou, S Xu, ...
Journal of medicinal chemistry 52 (16), 5009-5012, 2009
442009
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