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| RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether YC Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, ... Cell 179 (1), 147-164. e20, 2019 | 395 | 2019 |
| CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons R Tian, MA Gachechiladze, CH Ludwig, MT Laurie, JY Hong, D Nathaniel, ... Neuron 104 (2), 239-255. e12, 2019 | 333 | 2019 |
| Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ... Stem cell reports 9 (4), 1221-1233, 2017 | 269 | 2017 |
| SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β SH Cho, JA Chen, F Sayed, ME Ward, F Gao, TA Nguyen, G Krabbe, ... Journal of Neuroscience 35 (2), 807-818, 2015 | 261 | 2015 |
| Transcription factor–mediated differentiation of human iPSCs into neurons MS Fernandopulle, R Prestil, C Grunseich, C Wang, L Gan, ME Ward Current protocols in cell biology 79 (1), e51, 2018 | 252 | 2018 |
| Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models SS Minami, SW Min, G Krabbe, C Wang, Y Zhou, R Asgarov, Y Li, ... Nature medicine 20 (10), 1157-1164, 2014 | 246 | 2014 |
| TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A AL Brown, OG Wilkins, MJ Keuss, SE Hill, M Zanovello, WC Lee, ... Nature 603 (7899), 131-137, 2022 | 210 | 2022 |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity YJ Zhang, L Guo, PK Gonzales, TF Gendron, Y Wu, K Jansen-West, ... Science 363 (6428), eaav2606, 2019 | 208 | 2019 |
| Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis ME Ward, R Chen, HY Huang, C Ludwig, M Telpoukhovskaia, A Taubes, ... Science translational medicine 9 (385), eaah5642, 2017 | 173 | 2017 |
| The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin A Ungewickell, ME Ward, E Ungewickell, PW Majerus Proceedings of the National Academy of Sciences 101 (37), 13501-13506, 2004 | 159 | 2004 |
| Neuronal enhancers are hotspots for DNA single-strand break repair W Wu, SE Hill, WJ Nathan, J Paiano, E Callen, D Wang, K Shinoda, ... Nature 593 (7859), 440-444, 2021 | 141 | 2021 |
| Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia M Prudencio, J Humphrey, S Pickles, AL Brown, SE Hill, JM Kachergus, ... The Journal of clinical investigation 130 (11), 2020 | 129 | 2020 |
| The psychiatric cell map initiative: a convergent systems biological approach to illuminating key molecular pathways in neuropsychiatric disorders AJ Willsey, MT Morris, S Wang, HR Willsey, N Sun, N Teerikorpi, TB Baum, ... Cell 174 (3), 505-520, 2018 | 116 | 2018 |
| Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia G Krabbe, SS Minami, JI Etchegaray, P Taneja, B Djukic, D Davalos, D Le, ... Proceedings of the National Academy of Sciences 114 (19), 5029-5034, 2017 | 115 | 2017 |
| Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD ME Ward, A Taubes, R Chen, BL Miller, CF Sephton, JM Gelfand, ... Journal of Experimental Medicine 211 (10), 1937-1945, 2014 | 113 | 2014 |
| Lysosomal dysfunction at the centre of Parkinson’s disease and frontotemporal dementia/amyotrophic lateral sclerosis RL Wallings, SW Humble, ME Ward, R Wade-Martins Trends in neurosciences 42 (12), 899-912, 2019 | 106 | 2019 |
| RNA transport and local translation in neurodevelopmental and neurodegenerative disease MS Fernandopulle, J Lippincott-Schwartz, ME Ward Nature neuroscience 24 (5), 622-632, 2021 | 97 | 2021 |
| Systematic three-dimensional coculture rapidly recapitulates interactions between human neurons and astrocytes R Krencik, K Seo, JV van Asperen, N Basu, C Cvetkovic, S Barlas, ... Stem cell reports 9 (6), 1745-1753, 2017 | 97 | 2017 |
| Loss of TAX1BP1-directed autophagy results in protein aggregate accumulation in the brain SA Sarraf, HV Shah, G Kanfer, AM Pickrell, LA Holtzclaw, ME Ward, ... Molecular Cell 80 (5), 779-795. e10, 2020 | 96 | 2020 |
