Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors Y Bourne, TT Talley, SB Hansen, P Taylor, P Marchot The EMBO journal 24 (8), 1512-1522, 2005 | 382 | 2005 |
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism Y Bourne, Z Radić, R Aráoz, TT Talley, E Benoit, D Servent, P Taylor, ... Proceedings of the National Academy of Sciences 107 (13), 6076-6081, 2010 | 202 | 2010 |
Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica SB Hansen, TT Talley, Z Radic, P Taylor Journal of Biological Chemistry 279 (23), 24197-24202, 2004 | 191 | 2004 |
Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore TT Talley, M Harel, RE Hibbs, Z Radić, M Tomizawa, JE Casida, P Taylor Proceedings of the National Academy of Sciences 105 (21), 7606-7611, 2008 | 189 | 2008 |
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor RE Hibbs, G Sulzenbacher, J Shi, TT Talley, S Conrod, WR Kem, P Taylor, ... The EMBO journal 28 (19), 3040-3051, 2009 | 188 | 2009 |
Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein SB Hansen, Z Radić, TT Talley, BE Molles, T Deerinck, I Tsigelny, ... Journal of Biological Chemistry 277 (44), 41299-41302, 2002 | 129 | 2002 |
Mapping the elusive neonicotinoid binding site M Tomizawa, TT Talley, D Maltby, KA Durkin, KF Medzihradszky, ... Proceedings of the National Academy of Sciences 104 (21), 9075-9080, 2007 | 99 | 2007 |
Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template NP Grimster, B Stump, JR Fotsing, T Weide, TT Talley, JG Yamauchi, ... Journal of the American Chemical Society 134 (15), 6732-6740, 2012 | 94 | 2012 |
Atypical nicotinic agonist bound conformations conferring subtype selectivity M Tomizawa, D Maltby, TT Talley, KA Durkin, KF Medzihradszky, ... Proceedings of the National Academy of Sciences 105 (5), 1728-1732, 2008 | 92 | 2008 |
α-Conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as α3β2 and α7 nicotinic acetylcholine receptors TT Talley, BM Olivera, KH Han, SB Christensen, C Dowell, I Tsigelny, ... Journal of biological chemistry 281 (34), 24678-24686, 2006 | 74 | 2006 |
Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein RE Hibbs, TT Talley, P Taylor Journal of Biological Chemistry 279 (27), 28483-28491, 2004 | 68 | 2004 |
Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes P Taylor, TT Talley, SB Hansen, RE Hibbs, J Shi Biochemical pharmacology 74 (8), 1164-1171, 2007 | 61 | 2007 |
Defining nicotinic agonist binding surfaces through photoaffinity labeling M Tomizawa, D Maltby, KF Medzihradszky, N Zhang, KA Durkin, J Presley, ... Biochemistry 46 (30), 8798-8806, 2007 | 58 | 2007 |
Curariform antagonists bind in different orientations to acetylcholine-binding protein F Gao, N Bern, A Little, HL Wang, SB Hansen, TT Talley, P Taylor, ... Journal of Biological Chemistry 278 (25), 23020-23026, 2003 | 56 | 2003 |
Protein Folding Determinants: Structural Features Determining Alternative Disulfide Pairing in α- and χ/λ-Conotoxins, TS Kang, Z Radić, TT Talley, SDS Jois, P Taylor, RM Kini Biochemistry 46 (11), 3338-3355, 2007 | 54 | 2007 |
Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand− nicotinic receptor interactions TT Talley, S Yalda, KY Ho, Y Tor, FS Soti, WR Kem, P Taylor Biochemistry 45 (29), 8894-8902, 2006 | 54 | 2006 |
Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca++ Sensors JG Yamauchi, Á Nemecz, QT Nguyen, A Muller, LF Schroeder, TT Talley, ... PLoS one 6 (1), e16519, 2011 | 51 | 2011 |
Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system LP Rodríguez, N Vilariño, J Molgó, R Aráoz, MC Louzao, P Taylor, ... Analytical chemistry 85 (4), 2340-2347, 2013 | 44 | 2013 |
A virtual screening study of the acetylcholine binding protein using a relaxed–complex approach A Babakhani, TT Talley, P Taylor, JA McCammon Computational biology and chemistry 33 (2), 160-170, 2009 | 43 | 2009 |
Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related … JA Doorn, TT Talley, CM Thompson, RJ Richardson Chemical research in toxicology 14 (7), 807-813, 2001 | 40 | 2001 |