| Structural basis for inhibition of the epidermal growth factor receptor by cetuximab S Li, KR Schmitz, PD Jeffrey, JJW Wiltzius, P Kussie, KM Ferguson Cancer cell 7 (4), 301-311, 2005 | 1331 | 2005 |
| An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors AW Burgess, HS Cho, C Eigenbrot, KM Ferguson, TPJ Garrett, DJ Leahy, ... Molecular cell 12 (3), 541-552, 2003 | 1309 | 2003 |
| EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization KM Ferguson, MB Berger, JM Mendrola, HS Cho, DJ Leahy, MA Lemmon Molecular cell 11 (2), 507-517, 2003 | 1020 | 2003 |
| Signal-dependent membrane targeting by pleckstrin homology (PH) domains MA LEMMON, KM FERGUSON Biochemical Journal 350 (1), 1-18, 2000 | 999 | 2000 |
| Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain KM Ferguson, MA Lemmon, J Schlessinger, PB Sigler Cell 83 (6), 1037-1046, 1995 | 773 | 1995 |
| Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. MA Lemmon, KM Ferguson, R O'Brien, PB Sigler, J Schlessinger Proceedings of the National Academy of Sciences 92 (23), 10472-10476, 1995 | 730 | 1995 |
| PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface MA Lemmon, KM Ferguson, J Schlessinger Cell 85 (5), 621-624, 1996 | 606 | 1996 |
| The EGFR family: not so prototypical receptor tyrosine kinases MA Lemmon, J Schlessinger, KM Ferguson Cold Spring Harbor perspectives in biology 6 (4), a020768, 2014 | 480 | 2014 |
| Structure-based view of epidermal growth factor receptor regulation KM Ferguson Annu. Rev. Biophys. 37, 353-373, 2008 | 468 | 2008 |
| Identification and analysis of PH domain‐containing targets of phosphatidylinositol 3‐kinase using a novel in vivo assay in yeast SJ Isakoff, T Cardozo, J Andreev, Z Li, KM Ferguson, R Abagyan, ... The EMBO journal, 1998 | 434 | 1998 |
| Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains KM Ferguson, JM Kavran, VG Sankaran, E Fournier, SJ Isakoff, ... Molecular cell 6 (2), 373-384, 2000 | 413 | 2000 |
| Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface JP Dawson, MB Berger, CC Lin, J Schlessinger, MA Lemmon, ... Molecular and cellular biology 25 (17), 7734-7742, 2005 | 406 | 2005 |
| Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin KM Ferguson, MA Lemmon, J Schlessinger, PB Sigler Cell 79 (2), 199-209, 1994 | 349 | 1994 |
| Pleckstrin homology domains and the cytoskeleton MA Lemmon, KM Ferguson, CS Abrams FEBS letters 513 (1), 71-76, 2002 | 344 | 2002 |
| EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics DM Freed, NJ Bessman, A Kiyatkin, E Salazar-Cavazos, PO Byrne, ... Cell 171 (3), 683-695. e18, 2017 | 314 | 2017 |
| A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth RC Roovers, MJWD Vosjan, T Laeremans, R el Khoulati, RCG de Bruin, ... International journal of cancer 129 (8), 2013-2024, 2011 | 284 | 2011 |
| The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand S Bouyain, PA Longo, S Li, KM Ferguson, DJ Leahy Proceedings of the National Academy of Sciences 102 (42), 15024-15029, 2005 | 263 | 2005 |
| Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains KR Schmitz, A Bagchi, RC Roovers, PMPB en Henegouwen, ... Structure 21 (7), 1214-1224, 2013 | 219 | 2013 |
| Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization J Schmiedel, A Blaukat, S Li, T Knöchel, KM Ferguson Cancer cell 13 (4), 365-373, 2008 | 204 | 2008 |
| Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains MA Lemmon, M Falasca, J Schlessinger, K Ferguson Trends in Cell Biology 7 (6), 237-242, 1997 | 193 | 1997 |
Mark A. Lemmon, Ph.D., F.R.S.Alfred Gilman Professor and Chair of Pharmacology at Yale University, Co-Director, Canc. Biol. Inst.Verified email at yale.edu
