Alemayehu (Alex) Gorfe
Alemayehu (Alex) Gorfe
Professor, University of Texas McGovern Medical School-Houston
Verified email at - Homepage
Cited by
Cited by
Large conformational changes in proteins: signaling and other functions
BJ Grant, AA Gorfe, JA McCammon
Current opinion in structural biology 20 (2), 142-147, 2010
Structural determinants and functional consequences of protein affinity for membrane rafts
JH Lorent, B Diaz-Rohrer, X Lin, K Spring, AA Gorfe, KR Levental, ...
Nature communications 8 (1), 1219, 2017
Lipid-sorting specificity encoded in K-Ras membrane anchor regulates signal output
Y Zhou, P Prakash, H Liang, KJ Cho, AA Gorfe, JF Hancock
Cell 168 (1), 239-251. e16, 2017
Ras membrane orientation and nanodomain localization generate isoform diversity
D Abankwa, AA Gorfe, K Inder, JF Hancock
Proceedings of the National Academy of Sciences 107 (3), 1130-1135, 2010
Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins
AA Gorfe, BJ Grant, JA McCammon
Structure 16 (6), 885-896, 2008
Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1, 2-dimyristoylglycero-3-phosphocholine bilayer
AA Gorfe, M Hanzal-Bayer, D Abankwa, JF Hancock, JA McCammon
Journal of medicinal chemistry 50 (4), 674-684, 2007
A novel switch region regulates H‐ras membrane orientation and signal output
D Abankwa, M Hanzal‐Bayer, N Ariotti, SJ Plowman, AA Gorfe, RG Parton, ...
The EMBO journal 27 (5), 727-735, 2008
Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics
BJ Grant, AA Gorfe, JA McCammon
PLoS computational biology 5 (3), e1000325, 2009
Polyunsaturated lipids regulate membrane domain stability by tuning membrane order
KR Levental, JH Lorent, X Lin, AD Skinkle, MA Surma, EA Stockenbojer, ...
Biophysical journal 110 (8), 1800-1810, 2016
Novel allosteric sites on Ras for lead generation
BJ Grant, S Lukman, HJ Hocker, J Sayyah, JH Brown, JA McCammon, ...
PloS one 6 (10), e25711, 2011
Organization, dynamics, and segregation of Ras nanoclusters in membrane domains
L Janosi, Z Li, JF Hancock, AA Gorfe
Proceedings of the National Academy of Sciences, 2012
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
HJ Hocker, KJ Cho, CYK Chen, N Rambahal, SR Sagineedu, K Shaari, ...
Proceedings of the National Academy of Sciences 110 (25), 10201-10206, 2013
Ras nanoclusters: molecular structure and assembly
D Abankwa, AA Gorfe, JF Hancock
Seminars in cell & developmental biology 18 (5), 599-607, 2007
Oncogenic K-Ras binds to an anionic membrane in two distinct orientations: a molecular dynamics analysis
P Prakash, Y Zhou, H Liang, JF Hancock, AA Gorfe
Biophysical journal 110 (5), 1125-1138, 2016
Simulating POPC and POPC/POPG bilayers: Conserved packing and altered surface reactivity
L Janosi, AA Gorfe
Journal of chemical theory and computation 6 (10), 3267-3273, 2010
Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins
K Cho, JH Park, AM Piggott, AA Salim, AA Gorfe, RG Parton, RJ Capon, ...
Journal of Biological Chemistry 287 (52), 43573-43584, 2012
Functional plasticity in the substrate binding site of β-secretase
AA Gorfe, A Caflisch
Structure 13 (10), 1487-1498, 2005
Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers
P Prakash, A Sayyed-Ahmad, KJ Cho, DM Dolino, W Chen, H Li, BJ Grant, ...
Scientific reports 7 (1), 40109, 2017
Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds
CS Brand, HJ Hocker, AA Gorfe, CN Cavasotto, CW Dessauer
Journal of Pharmacology and Experimental Therapeutics 347 (2), 265-275, 2013
The distinct conformational dynamics of K-Ras and H-Ras A59G
S Lukman, BJ Grant, AA Gorfe, GH Grant, JA McCammon
PLoS computational biology 6 (9), e1000922, 2010
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