Nicole G. H. Leferink
Nicole G. H. Leferink
Research Fellow Future BRH, Manchester Intsitute of Biotechnology (MIB), University of Manchester
Verified email at - Homepage
Cited by
Cited by
3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities
RK Kuipers, HJ Joosten, WJH Van Berkel, NGH Leferink, E Rooijen, ...
Proteins: Structure, Function, and Bioinformatics 78 (9), 2101-2113, 2010
The growing VAO flavoprotein family
NGH Leferink, DPHM Heuts, MW Fraaije, WJH van Berkel
Archives of biochemistry and biophysics 474 (2), 292-301, 2008
l‐Galactono‐γ‐lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis
NGH Leferink, WAM van den Berg, WJH van Berkel
The FEBS journal 275 (4), 713-726, 2008
Identification of a Gatekeeper Residue That Prevents Dehydrogenases from Acting as Oxidases*♦
NGH Leferink, MW Fraaije, HJ Joosten, PJ Schaap, A Mattevi, ...
Journal of Biological Chemistry 284 (7), 4392-4397, 2009
Correlated mutation analyses on super‐family alignments reveal functionally important residues
RKP Kuipers, HJ Joosten, E Verwiel, S Paans, J Akerboom, ...
Proteins: Structure, Function, and Bioinformatics 76 (3), 608-616, 2009
Occurrence and biocatalytic potential of carbohydrate oxidases
EW van Hellemond, NGH Leferink, DPHM Heuts, MW Fraaije, ...
Advances in applied microbiology 60, 17, 2006
Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase
NGH Leferink, C Han, SV Antonyuk, DJ Heyes, SEJ Rigby, MA Hough, ...
Biochemistry 50 (19), 4121-4131, 2011
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase
V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ...
Acs Catalysis 7 (9), 6268-6282, 2017
Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C
NGH Leferink, E Van Duijn, A Barendregt, AJR Heck, WJH Van Berkel
Plant physiology 150 (2), 596-605, 2009
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase
NGH Leferink, SV Antonyuk, JA Houwman, NS Scrutton, RR Eady, ...
Nature Communications 5 (1), 4395, 2014
Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures
R Machielsen, NGH Leferink, A Hendriks, SJJ Brouns, HG Hennemann, ...
Extremophiles 12, 587-594, 2008
A ‘Plug and Play’ Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli.
NGH Leferink, AJ Jervis, Z Zebec, HS Toogood, S Hay, E Takano, ...
ChemistrySelect 1 (9), 1893-1896, 2016
Exploring novel bacterial terpene synthases
GK Reddy, NGH Leferink, M Umemura, ST Ahmed, R Breitling, ...
PloS one 15 (4), e0232220, 2020
Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent …
NGH Leferink, CR Pudney, S Brenner, DJ Heyes, RR Eady, SS Hasnain, ...
FEBS letters 586 (5), 578-584, 2012
Experiment and simulation reveal how mutations in functional plasticity regions guide plant monoterpene synthase product outcome
NGH Leferink, KE Ranaghan, V Karuppiah, A Currin, MW Van Der Kamp, ...
ACS catalysis 8 (5), 3780-3791, 2018
Energy landscapes and catalysis in nitric-oxide synthase
A Sobolewska-Stawiarz, NGH Leferink, K Fisher, DJ Heyes, S Hay, ...
Journal of Biological Chemistry 289 (17), 11725-11738, 2014
Towards the free energy landscape for catalysis in mammalian nitric oxide synthases
NGH Leferink, S Hay, SEJ Rigby, NS Scrutton
The FEBS Journal 282 (16), 3016-3029, 2015
Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers
ST Ahmed, NGH Leferink, NS Scrutton
Molecular catalysis 467, 95-110, 2019
Isopentenol Utilization Pathway for the Production of Linalool in Escherichia coli Using an Improved Bacterial Linalool/Nerolidol Synthase
CA Ferraz, NGH Leferink, I Kosov, NS Scrutton
ChemBioChem 22 (13), 2325-2334, 2021
Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c
M Hervás, Q Bashir, NGH Leferink, P Ferreira, B Moreno‐Beltrán, ...
The FEBS journal 280 (8), 1830-1840, 2013
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