| Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products Y Nicolet, O Lockridge, P Masson, JC Fontecilla-Camps, F Nachon Journal of Biological Chemistry 278 (42), 41141-41147, 2003 | 942 | 2003 |
| Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl-and butyryl-cholinesterase F Nachon, E Carletti, C Ronco, M Trovaslet, Y Nicolet, L Jean, PY Renard Biochemical Journal 453 (3), 393-399, 2013 | 431 | 2013 |
| Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents G Mercey, T Verdelet, J Renou, M Kliachyna, R Baati, F Nachon, L Jean, ... Accounts of chemical research 45 (5), 756-766, 2012 | 417 | 2012 |
| Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study TL Rosenberry, X Brazzolotto, IR Macdonald, M Wandhammer, ... Molecules 22 (12), 2098, 2017 | 244 | 2017 |
| Progress in the development of enzyme-based nerve agent bioscavengers F Nachon, X Brazzolotto, M Trovaslet, P Masson Chemico-biological interactions 206 (3), 536-544, 2013 | 195 | 2013 |
| Engineering of a monomeric and low‐glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization F Nachon, Y Nicolet, N Viguié, P Masson, JC Fontecilla‐Camps, ... European Journal of Biochemistry 269 (2), 630-637, 2002 | 167 | 2002 |
| Discovery and structure–activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening SN Dighe, GS Deora, E De la Mora, F Nachon, S Chan, MO Parat, ... Journal of medicinal chemistry 59 (16), 7683-7689, 2016 | 158 | 2016 |
| The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ... Journal of medicinal chemistry 61 (1), 119-139, 2018 | 155 | 2018 |
| Development of an in-vivo active reversible butyrylcholinesterase inhibitor U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ... Scientific reports 6 (1), 39495, 2016 | 153 | 2016 |
| Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation E Carletti, H Li, B Li, F Ekström, Y Nicolet, M Loiodice, E Gillon, ... Journal of the American Chemical Society 130 (47), 16011-16020, 2008 | 137 | 2008 |
| First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase G Mercey, T Verdelet, G Saint-André, E Gillon, A Wagner, R Baati, L Jean, ... Chemical Communications 47 (18), 5295-5297, 2011 | 128 | 2011 |
| Cholinesterase reactivators and bioscavengers for pre‐and post‐exposure treatments of organophosphorus poisoning P Masson, F Nachon Journal of neurochemistry 142, 26-40, 2017 | 125 | 2017 |
| Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation E Carletti, JP Colletier, F Dupeux, M Trovaslet, P Masson, F Nachon Journal of Medicinal Chemistry 53 (10), 4002-4008, 2010 | 122 | 2010 |
| Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging, F Nachon, OA Asojo, GEO Borgstahl, P Masson, O Lockridge Biochemistry 44 (4), 1154-1162, 2005 | 120 | 2005 |
| Structure, activities and biomedical applications of human butyrylcholinesterase P Masson, E Carletti, F Nachon Protein and peptide letters 16 (10), 1215-1224, 2009 | 117 | 2009 |
| Binding and hydrolysis of soman by human serum albumin B Li, F Nachon, MT Froment, L Verdier, JC Debouzy, B Brasme, E Gillon, ... Chemical research in toxicology 21 (2), 421-431, 2008 | 116 | 2008 |
| Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime B Sanson, F Nachon, JP Colletier, MT Froment, L Toker, HM Greenblatt, ... Journal of medicinal chemistry 52 (23), 7593-7603, 2009 | 114 | 2009 |
| Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure X Brazzolotto, M Wandhammer, C Ronco, M Trovaslet, L Jean, ... The FEBS journal 279 (16), 2905-2916, 2012 | 113 | 2012 |
| Exposure to tri-o-cresyl phosphate detected in jet airplane passengers M Liyasova, B Li, LM Schopfer, F Nachon, P Masson, CE Furlong, ... Toxicology and applied pharmacology 256 (3), 337-347, 2011 | 105 | 2011 |
| Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease K Chalupova, J Korabecny, M Bartolini, B Monti, D Lamba, R Caliandro, ... European journal of medicinal chemistry 168, 491-514, 2019 | 103 | 2019 |
