| The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 831 | 2015 |
| Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors X Zhu, JL Kim, JR Newcomb, PE Rose, DR Stover, LM Toledo, H Zhao, ... Structure 7 (6), 651-661, 1999 | 324 | 1999 |
| The structure-based design of ATP-site directed protein kinases LM Toledo, NB Lydon, D Elbaum Curr. Med. Chem 6, 775-805, 1999 | 263 | 1999 |
| Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571 AS Corbin, E Buchdunger, F Pascal, BJ Druker Journal of Biological Chemistry 277 (35), 32214-32219, 2002 | 258 | 2002 |
| Molecular symmetry and the design of molecular solids: The oxalamide functionality as a persistent hydrogen bonding unit S Coe, JJ Kane, TL Nguyen, LM Toledo, E Wininger, FW Fowler, ... Journal of the American Chemical Society 119 (1), 86-93, 1997 | 161 | 1997 |
| Synthesis and self-assembly of pseudo-spherical homo-and heterodimeric capsules C Valdes, UP Spitz, LM Toledo, SW Kubik, J Rebek Jr Journal of the American Chemical Society 117 (51), 12733-12745, 1995 | 122 | 1995 |
| Kinase inhibitors D Armistead, J Bemis, L DiPietro, S Geuns-Meyer, G Habgood, J Kim, ... US Patent App. 09/785,599, 2002 | 105 | 2002 |
| Structures of staurosporine bound to CDK2 and cAPK–new tools for structure-based design of protein kinase inhibitors LM Toledo, NB Lydon Structure 5 (12), 1551-1556, 1997 | 103 | 1997 |
| Kinase inhibitors DM Armistead, JE Bemis, LV DiPietro, SD Geuns-Meyer, GJ Habgood, ... US Patent 7,282,504, 2007 | 99 | 2007 |
| Discovery and structure–activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington’s disease ME Prime, OA Andersen, JJ Barker, MA Brooks, RKY Cheng, ... Journal of medicinal chemistry 55 (3), 1021-1046, 2012 | 85 | 2012 |
| Energetics of a low barrier hydrogen bond in nonpolar solvents Y Kato, LM Toledo, J Rebek Journal of the American Chemical Society 118 (36), 8575-8579, 1996 | 82 | 1996 |
| Kinase inhibitors D Armistead, J Bemis, D Elbaum, G Habgood, P Novak, J Nunes, ... US Patent App. 10/278,369, 2004 | 73 | 2004 |
| Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington’s disease LM Toledo-Sherman, ME Prime, L Mrzljak, MG Beconi, A Beresford, ... Journal of medicinal chemistry 58 (3), 1159-1183, 2015 | 68 | 2015 |
| Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening L Toledo-Sherman, E Deretey, JJ Slon-Usakiewicz, W Ng, JR Dai, ... Journal of medicinal chemistry 48 (9), 3221-3230, 2005 | 66 | 2005 |
| Diels-Alder reaction of 2-cyano-1-azadienes. The effect of nitrogen substituents C Trione, LM Toledo, SD Kuduk, FW Fowler, DS Grierson The Journal of Organic Chemistry 58 (8), 2075-2080, 1993 | 59 | 1993 |
| Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery JJ Slon-Usakiewicz, JR Dai, W Ng, JE Foster, E Deretey, ... Analytical chemistry 77 (5), 1268-1274, 2005 | 56 | 2005 |
| Current directions in tau research: Highlights from Tau 2020 C Sexton, H Snyder, D Beher, AL Boxer, P Brannelly, JP Brion, L Buée, ... Alzheimer's & Dementia 18 (5), 988-1007, 2022 | 53 | 2022 |
| High-throughput virtual screening for drug discovery in parallel. LM Toledo-Sherman, D Chen Current opinion in drug discovery & development 5 (3), 414-421, 2002 | 52 | 2002 |
| The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease V Beaumont, L Mrzljak, U Dijkman, R Freije, M Heins, A Rassoulpour, ... Experimental neurology 282, 99-118, 2016 | 50 | 2016 |
| Kinase inhibitors DM Armistead, JE Bemis, JL Buchanan, LV DiPietro, D Elbaum, ... US Patent 7,074,789, 2006 | 48 | 2006 |
