| Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19 RT Eastman, JS Roth, KR Brimacombe, A Simeonov, M Shen, S Patnaik, ... ACS central Science 6 (5), 672-683, 2020 | 895 | 2020 |
| Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries J Inglese, DS Auld, A Jadhav, RL Johnson, A Simeonov, A Yasgar, ... Proceedings of the National Academy of Sciences 103 (31), 11473-11478, 2006 | 875 | 2006 |
| High-throughput screening assays for the identification of chemical probes J Inglese, RL Johnson, A Simeonov, M Xia, W Zheng, CP Austin, DS Auld Nature chemical biology 3 (8), 466-479, 2007 | 739 | 2007 |
| Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions SAI Seidel, PM Dijkman, WA Lea, G van den Bogaart, ... Methods 59 (3), 301-315, 2013 | 701 | 2013 |
| Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen M Xu, EM Lee, Z Wen, Y Cheng, WK Huang, X Qian, J Tcw, ... Nature medicine 22 (10), 1101-1107, 2016 | 687 | 2016 |
| Fluorescence polarization assays in small molecule screening WA Lea, A Simeonov Expert opinion on drug discovery 6 (1), 17-32, 2011 | 490 | 2011 |
| A high-throughput screen for aggregation-based inhibition in a large compound library BY Feng, A Simeonov, A Jadhav, K Babaoglu, J Inglese, BK Shoichet, ... Journal of medicinal chemistry 50 (10), 2385-2390, 2007 | 412 | 2007 |
| High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ... Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014 | 403 | 2014 |
| Gene expression analysis identifies global gene dosage sensitivity in cancer RSN Fehrmann, JM Karjalainen, M Krajewska, HJ Westra, D Maloney, ... Nature genetics 47 (2), 115-125, 2015 | 389 | 2015 |
| Unexplored therapeutic opportunities in the human genome TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ... Nature reviews Drug discovery 17 (5), 317-332, 2018 | 362 | 2018 |
| Identification of oxadiazoles as new drug leads for the control of schistosomiasis AA Sayed, A Simeonov, CJ Thomas, J Inglese, CP Austin, DL Williams Nature medicine 14 (4), 407-412, 2008 | 317 | 2008 |
| A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth L Wang, J Chang, D Varghese, M Dellinger, S Kumar, AM Best, J Ruiz, ... Nature communications 4 (1), 2035, 2013 | 314 | 2013 |
| Fluorescence spectroscopic profiling of compound libraries A Simeonov, A Jadhav, CJ Thomas, Y Wang, R Huang, NT Southall, ... Journal of medicinal chemistry 51 (8), 2363-2371, 2008 | 285 | 2008 |
| Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization R Huang, M Xia, S Sakamuru, J Zhao, SA Shahane, M Attene-Ramos, ... Nature communications 7 (1), 10425, 2016 | 281 | 2016 |
| Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors RS Ferreira, A Simeonov, A Jadhav, O Eidam, BT Mott, MJ Keiser, ... Journal of medicinal chemistry 53 (13), 4891-4905, 2010 | 268 | 2010 |
| Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease A Jadhav, RS Ferreira, C Klumpp, BT Mott, CP Austin, J Inglese, ... Journal of medicinal chemistry 53 (1), 37-51, 2010 | 256 | 2010 |
| Pharos: collating protein information to shed light on the druggable genome DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ... Nucleic acids research 45 (D1), D995-D1002, 2017 | 254 | 2017 |
| Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ... Journal of medicinal chemistry 52 (24), 7950-7953, 2009 | 246 | 2009 |
| Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors ONF King, XS Li, M Sakurai, A Kawamura, NR Rose, SS Ng, AM Quinn, ... PloS one 5 (11), e15535, 2010 | 243 | 2010 |
| The Tox21 robotic platform for the assessment of environmental chemicals–from vision to reality MS Attene-Ramos, N Miller, R Huang, S Michael, M Itkin, RJ Kavlock, ... Drug discovery today 18 (15-16), 716-723, 2013 | 241 | 2013 |
James IngleseADST Laboratory, NCATS, Adjunct Investigator NHGRI, NIHVerified email at mail.nih.gov
