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Jiankang (Jack) Jiang
Jiankang (Jack) Jiang
Staff Scientist, National Center for Advancing Translational Sciences, NIH
Verified email at mail.nih.gov
Title
Cited by
Cited by
Year
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
RE Davis, VN Ngo, G Lenz, P Tolar, RM Young, PB Romesser, ...
Nature 463 (7277), 88-92, 2010
18812010
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ...
Science 334 (6060), 1278-1283, 2011
12162011
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
EM Palsson-McDermott, AM Curtis, G Goel, MAR Lauterbach, FJ Sheedy, ...
Cell metabolism 21 (1), 65-80, 2015
11012015
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
7712012
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ...
Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014
4032014
Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase
MB Boxer, J Jiang, MG Vander Heiden, M Shen, AP Skoumbourdis, ...
Journal of medicinal chemistry 53 (3), 1048-1055, 2010
1882010
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion
J Feng, CD Petersen, DH Coy, JK Jiang, CJ Thomas, MR Pollak, ...
Proceedings of the National Academy of Sciences 107 (41), 17791-17796, 2010
1512010
Evaluation of thieno [3, 2-b] pyrrole [3, 2-d] pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
J Jiang, MB Boxer, MG Vander Heiden, M Shen, AP Skoumbourdis, ...
Bioorganic & medicinal chemistry letters 20 (11), 3387-3393, 2010
1462010
Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3 …
J Jiang, K Ghoreschi, F Deflorian, Z Chen, M Perreira, M Pesu, J Smith, ...
Journal of medicinal chemistry 51 (24), 8012-8018, 2008
1432008
Selective targeting of ITK blocks multiple steps of HIV replication
JA Readinger, GM Schiralli, JK Jiang, CJ Thomas, A August, ...
Proceedings of the National Academy of Sciences 105 (18), 6684-6689, 2008
1342008
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin …
H Jäschke, S Neumann, S Moore, CJ Thomas, AO Colson, S Costanzi, ...
Journal of Biological Chemistry 281 (15), 9841-9844, 2006
1162006
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism
S Neumann, G Kleinau, S Costanzi, S Moore, J Jiang, BM Raaka, ...
Endocrinology 149 (12), 5945-5950, 2008
1132008
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation
R Nayar, M Enos, A Prince, HM Shin, S Hemmers, J Jiang, U Klein, ...
Proceedings of the National Academy of Sciences 109 (41), E2794-E2802, 2012
1102012
A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+
J Hu, SJ McLarnon, S Mora, J Jiang, C Thomas, KA Jacobson, ...
Journal of Biological Chemistry 280 (6), 5113-5120, 2005
1082005
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure− activity relationships and selective …
S Moore, H Jaeschke, G Kleinau, S Neumann, S Costanzi, J Jiang, ...
Journal of medicinal chemistry 49 (13), 3888-3896, 2006
1042006
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity
G Lu, E Lomonosova, X Cheng, EA Moran, MJ Meyers, SFJ Le Grice, ...
Antimicrobial agents and chemotherapy 59 (2), 1070-1079, 2015
932015
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H
S Chung, DM Himmel, JK Jiang, K Wojtak, JD Bauman, JW Rausch, ...
Journal of medicinal chemistry 54 (13), 4462-4473, 2011
902011
“Reversine” and Its 2-Substituted Adenine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists
M Perreira, J Jiang, AM Klutz, ZG Gao, A Shainberg, C Lu, CJ Thomas, ...
Journal of medicinal chemistry 48 (15), 4910-4918, 2005
882005
RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction
J Li, S Vootukuri, Y Shang, A Negri, J Jiang, M Nedelman, TG Diacovo, ...
Arteriosclerosis, thrombosis, and vascular biology 34 (10), 2321-2329, 2014
852014
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP
W Ju, M Zhang, J Jiang, CJ Thomas, U Oh, BR Bryant, J Chen, N Sato, ...
Blood, The Journal of the American Society of Hematology 117 (6), 1938-1946, 2011
802011
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