Gabriel Simon
Gabriel Simon
VP of Discovery at Vividion Therapeutics
Verified email at
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Quantitative reactivity profiling predicts functional cysteines in proteomes
E Weerapana, C Wang, GM Simon, F Richter, S Khare, MBD Dillon, ...
Nature 468 (7325), 790-795, 2010
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
JL Blankman, GM Simon, BF Cravatt
Chemistry & biology 14 (12), 1347-1356, 2007
The biological impact of mass-spectrometry-based proteomics
BF Cravatt, GM Simon, JR Yates Iii
Nature 450 (7172), 991-1000, 2007
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for α/β-hydrolase 4 in this pathway
GM Simon, BF Cravatt
Journal of Biological Chemistry 281 (36), 26465-26472, 2006
Inactivation of N-Acyl Phosphatidylethanolamine Phospholipase D Reveals Multiple Mechanisms for the Biosynthesis of Endocannabinoids
D Leung, A Saghatelian, GM Simon, BF Cravatt
Biochemistry 45 (15), 4720-4726, 2006
Global mapping of the topography and magnitude of proteolytic events in apoptosis
MM Dix, GM Simon, BF Cravatt
Cell 134 (4), 679-691, 2008
Bacteria from diverse habitats colonize and compete in the mouse gut
H Seedorf, NW Griffin, VK Ridaura, A Reyes, J Cheng, FE Rey, MI Smith, ...
Cell 159 (2), 253-266, 2014
Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study
GM Simon, BF Cravatt
Journal of Biological Chemistry 285 (15), 11051-11055, 2010
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
DA Bachovchin, T Ji, W Li, GM Simon, JL Blankman, A Adibekian, ...
Proceedings of the National Academy of Sciences 107 (49), 20941-20946, 2010
Disparate proteome reactivity profiles of carbon electrophiles
E Weerapana, GM Simon, BF Cravatt
Nature chemical biology 4 (7), 405-407, 2008
Determining target engagement in living systems
GM Simon, MJ Niphakis, BF Cravatt
Nature chemical biology 9 (4), 200-205, 2013
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain
GM Simon, BF Cravatt
Journal of Biological Chemistry 283 (14), 9341-9349, 2008
An activity-guided map of electrophile-cysteine interactions in primary human T cells
EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ...
Cell 182 (4), 1009-1026. e29, 2020
The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex
DE Sterner, X Wang, MH Bloom, GM Simon, SL Berger
Journal of Biological Chemistry 277 (10), 8178-8186, 2002
Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo
GM Simon, BF Cravatt
Molecular BioSystems 6 (8), 1411-1418, 2010
Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome
MM Dix, GM Simon, C Wang, E Okerberg, MP Patricelli, BF Cravatt
Cell 150 (2), 426-440, 2012
Localization of N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) expression in mouse brain: A new perspective on N‐acylethanolamines as neural signaling molecules
M Egertová, GM Simon, BF Cravatt, MR Elphick
Journal of Comparative Neurology 506 (4), 604-615, 2008
Biomarkers of endocannabinoid system activation in severe obesity
JC Sipe, TM Scott, S Murray, O Harismendy, GM Simon, BF Cravatt, ...
PloS one 5 (1), e8792, 2010
Activation of the endocannabinoid system by organophosphorus nerve agents
DK Nomura, JL Blankman, GM Simon, K Fujioka, RS Issa, AM Ward, ...
Nature chemical biology 4 (6), 373-378, 2008
Identification of ABX-1431, a selective inhibitor of monoacylglycerol lipase and clinical candidate for treatment of neurological disorders
JS Cisar, OD Weber, JR Clapper, JL Blankman, CL Henry, GM Simon, ...
Journal of medicinal chemistry 61 (20), 9062-9084, 2018
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