Mike Hough
Mike Hough
Principal beamline scientist, Diamond light Source; Honorary Professor of Structural Biology
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The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis
RW Strange, S Antonyuk, MA Hough, PA Doucette, JA Rodriguez, PJ Hart, ...
Journal of molecular biology 328 (4), 877-891, 2003
Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants
MA Hough, JG Grossmann, SV Antonyuk, RW Strange, PA Doucette, ...
Proceedings of the National Academy of Sciences 101 (16), 5976-5981, 2004
Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu–Zn, Zn–Zn and as-isolated wild-type enzymes
RW Strange, SV Antonyuk, MA Hough, PA Doucette, JS Valentine, ...
Journal of molecular biology 356 (5), 1152-1162, 2006
Crystallographic structures of bovine copper-zinc superoxide dismutase reveal asymmetry in two subunits: functionally important three and five coordinate copper sites captured …
MA Hough, SS Hasnain
Journal of molecular biology 287 (3), 579-592, 1999
Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase
MA Hough, SV Antonyuk, RW Strange, RR Eady, SS Hasnain
Journal of molecular biology 378 (2), 353-361, 2008
Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 Ć
MA Hough, SS Hasnain
Structure 11 (8), 937-946, 2003
Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg
S Antonyuk, JS Elam, MA Hough, RW Strange, PA Doucette, ...
Protein Science 14 (5), 1201-1213, 2005
The hydrogen-peroxide-induced radical behaviour in human cytochrome c–phospholipid complexes: implications for the enhanced pro-apoptotic activity of the …
BS Rajagopal, AN Edzuma, MA Hough, KLIM Blundell, VE Kagan, ...
Biochemical Journal 456 (3), 441-452, 2013
Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase
NGH Leferink, C Han, SV Antonyuk, DJ Heyes, SEJ Rigby, MA Hough, ...
Biochemistry 50 (19), 4121-4131, 2011
GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis of Streptomyces lividans
AK Chaplin, MLC Petrus, G Mangiameli, MA Hough, DA Svistunenko, ...
Biochemical Journal 469 (3), 433-444, 2015
Response to copper stress in Streptomyces lividans extends beyond genes under direct control of a copper-sensitive operon repressor protein (CsoR)
S Dwarakanath, AK Chaplin, MA Hough, S Rigali, E Vijgenboom, ...
Journal of Biological Chemistry 287 (21), 17833-17847, 2012
Conformational variability of the Cu site in one subunit of bovine CuZn superoxide dismutase: the importance of mobility in the Glu119-Leu142 loop region for catalytic function
MA Hough, RW Strange, SS Hasnain
Journal of Molecular Biology 304 (2), 231-241, 2000
Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins
A Ebrahim, T Moreno-Chicano, MV Appleby, AK Chaplin, JH Beale, ...
IUCrJ 6 (4), 543-551, 2019
Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal
S Horrell, SV Antonyuk, RR Eady, SS Hasnain, MA Hough, RW Strange
IUCrJ 3 (4), 271-281, 2016
Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases
S Brenner, DJ Heyes, S Hay, MA Hough, RR Eady, SS Hasnain, ...
Journal of Biological Chemistry 284 (38), 25973-25983, 2009
Heterogeneity in the histidine-brace copper coordination sphere in auxiliary activity family 10 (AA10) lytic polysaccharide monooxygenases
AK Chaplin, MT Wilson, MA Hough, DA Svistunenko, GR Hemsworth, ...
Journal of Biological Chemistry 291 (24), 12838-12850, 2016
Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: insights into the structural relationship with the cupredoxins and the …
LD Kanbi, S Antonyuk, MA Hough, JF Hall, FE Dodd, SS Hasnain
Journal of molecular biology 320 (2), 263-275, 2002
Recent structural insights into the function of copper nitrite reductases
S Horrell, D Kekilli, RW Strange, MA Hough
Metallomics 9 (11), 1470-1482, 2017
Atomic Resolution Crystal Structures, EXAFS, and Quantum Chemical Studies of Rusticyanin and Its Two Mutants Provide Insight into Its Unusual Properties,
ML Barrett, I Harvey, M Sundararajan, R Surendran, JF Hall, MJ Ellis, ...
Biochemistry 45 (9), 2927-2939, 2006
Active site structures and the redox properties of blue copper proteins: atomic resolution structure of azurin II and electronic structure calculations of azurin, plastocyanin …
K Paraskevopoulos, M Sundararajan, R Surendran, MA Hough, RR Eady, ...
Dalton Transactions, 3067-3076, 2006
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