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Torbjörn Gräslund
Torbjörn Gräslund
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Affibody molecules in biotechnological and medical applications
S Ståhl, T Gräslund, AE Karlström, FY Frejd, PÅ Nygren, J Löfblom
Trends in biotechnology 35 (8), 691-712, 2017
3292017
Improving the tolerance of a protein a analogue to repeated alkaline exposures using a bypass mutagenesis approach
M Linhult, S Gülich, T Gräslund, A Simon, M Karlsson, A Sjöberg, K Nord, ...
Proteins: structure, function, and bioinformatics 55 (2), 407-416, 2004
1432004
Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of γ-globin expression and the …
T Gräslund, X Li, L Magnenat, M Popkov, CF Barbas
Journal of Biological Chemistry 280 (5), 3707-3714, 2005
1162005
S100A4 interacts with p53 in the nucleus and promotes p53 degradation
LM Orre, E Panizza, VO Kaminskyy, E Vernet, T Gräslund, B Zhivotovsky, ...
Oncogene 32 (49), 5531-5540, 2013
1062013
HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [99mTc(CO)3]+, and Shows Improved Biodistribution with Reduced …
V Tolmachev, C Hofström, J Malmberg, S Ahlgren, SJ Hosseinimehr, ...
Bioconjugate chemistry 21 (11), 2013-2022, 2010
1022010
Charge engineering of a protein domain to allow efficient ion-exchange recovery
T Gräslund, G Lundin, M Uhlén, PÅ Nygren, S Hober
Protein Engineering 13 (10), 703-709, 2000
862000
Evolution of programmable zinc finger-recombinases with activity in human cells
RM Gordley, JD Smith, T Gräslund, CF Barbas III
Journal of molecular biology 367 (3), 802-813, 2007
782007
Use of a HEHEHE purification tag instead of a hexahistidine tag improves biodistribution of affibody molecules site-specifically labeled with 99mTc, 111In, and 125I
C Hofström, A Orlova, M Altai, F Wångsell, T Gräslund, V Tolmachev
Journal of medicinal chemistry 54 (11), 3817-3826, 2011
732011
HAHAHA, HEHEHE, HIHIHI, or HKHKHK: Influence of Position and Composition of Histidine Containing Tags on Biodistribution of [99mTc(CO)3]+-Labeled …
C Hofström, M Altai, H Honarvar, J Strand, J Malmberg, ...
Journal of medicinal chemistry 56 (12), 4966-4974, 2013
712013
Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the affibody molecule 111In-DOTA-ZIGF1R: 4551
V Tolmachev, J Malmberg, C Hofström, L Abrahmsén, T Bergman, ...
Journal of Nuclear Medicine 53 (1), 90-97, 2012
622012
Protein engineering strategies for selective protein purification
M Hedhammar, T Gräslund, S Hober
Chemical Engineering & Technology: Industrial Chemistry‐Plant Equipment …, 2005
612005
Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors
M Altai, H Liu, H Ding, B Mitran, PH Edqvist, V Tolmachev, A Orlova, ...
Journal of controlled release 288, 84-95, 2018
582018
An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein
J Seijsing, M Lindborg, I Höidén-Guthenberg, H Bönisch, E Guneriusson, ...
Proceedings of the National Academy of Sciences 111 (48), 17110-17115, 2014
572014
Display of active subtilisin 309 on phage: analysis of parameters influencing the selection of subtilisin variants with changed substrate specificity from libraries using …
D Legendre, N Laraki, T Gräslund, ME Bjørnvad, M Bouchet, PÅ Nygren, ...
Journal of molecular biology 296 (1), 87-102, 2000
572000
Site-specifically conjugated anti-HER2 Affibody® molecules as one-step reagents for target expression analyses on cells and xenograft samples
E Lundberg, I Höidén-Guthenberg, B Larsson, M Uhlén, T Gräslund
Journal of immunological methods 319 (1-2), 53-63, 2007
542007
Selection of affibody molecules to the ligand‐binding site of the insulin‐like growth factor‐1 receptor
J Li, E Lundberg, E Vernet, B Larsson, I Höidén‐Guthenberg, T Gräslund
Biotechnology and applied biochemistry 55 (2), 99-109, 2010
472010
[99mTc(CO)3]+-(HE)3-ZIGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours
A Orlova, C Hofström, J Strand, Z Varasteh, M Sandstrom, K Andersson, ...
European journal of nuclear medicine and molecular imaging 40, 439-449, 2013
462013
In vitro selection of enzymatically active lipase variants from phage libraries using a mechanism-based inhibitor
S Danielsen, M Eklund, HJ Deussen, T Gräslund, PÅ Nygren, TV Borchert
Gene 272 (1-2), 267-274, 2001
462001
Integrated strategy for selective expanded bed ion-exchange adsorption and site-specific protein processing using gene fusion technology
T Gräslund, M Hedhammar, M Uhlén, PÅ Nygren, S Hober
Journal of biotechnology 96 (1), 93-102, 2002
442002
In vivo depletion of serum IgG by an affibody molecule binding the neonatal Fc receptor
J Seijsing, S Yu, FY Frejd, I Höiden-Guthenberg, T Gräslund
Scientific Reports 8 (1), 5141, 2018
382018
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