| Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors NS Gray, L Wodicka, AMWH Thunnissen, TC Norman, S Kwon, ... Science 281 (5376), 533-538, 1998 | 1137 | 1998 |
| Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent L Meijer, AMWH Thunnissen, AW White, M Garnier, M Nikolic, LH Tsai, ... Chemistry & biology 7 (1), 51-63, 2000 | 591 | 2000 |
| Crystal Structures of the ATPase Subunit of the Glucose ABC Transporter from Sulfolobus solfataricus: Nucleotide-free and Nucleotide-bound Conformations G Verdon, SV Albers, BW Dijkstra, AJM Driessen, AMWH Thunnissen Journal of molecular biology 330 (2), 343-358, 2003 | 210 | 2003 |
| Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography AMWH Thunnissen, AJ Dijkstra, KH Kalk, HJ Rozeboom, H Engel, W Keck, ... Nature 367 (6465), 750-753, 1994 | 200 | 1994 |
| Subunit and chlorophyll organization of the plant photosystem II supercomplex LS van Bezouwen, S Caffarri, RS Kale, R Kouřil, AMWH Thunnissen, ... Nature Plants 3 (7), 1-11, 2017 | 149 | 2017 |
| Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymic mechanism AMWH Thunnissen, HJ Rozeboom, KH Kalk, BW Dijkstra Biochemistry 34 (39), 12729-12737, 1995 | 142 | 1995 |
| High resolution crystal structures of the Escherichia coli lytic transglycosylase Slt70 and its complex with a peptidoglycan fragment EJ Van Asselt, AMWH Thunnissen, BW Dijkstra Journal of molecular biology 291 (4), 877-898, 1999 | 141 | 1999 |
| Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition PK Madoori, H Agustiandari, AJM Driessen, AMWH Thunnissen The EMBO journal 28 (2), 156-166, 2009 | 140 | 2009 |
| Formation of the productive ATP-Mg2+-bound dimer of GlcV, an ABC-ATPase from Sulfolobus solfataricus G Verdon, SV Albers, N van Oosterwijk, BW Dijkstra, AJM Driessen, ... Journal of molecular biology 334 (2), 255-267, 2003 | 124 | 2003 |
| An artificial heme enzyme for cyclopropanation reactions L Villarino, KE Splan, E Reddem, L Alonso‐Cotchico, ... Angewandte Chemie International Edition 57 (26), 7785-7789, 2018 | 111 | 2018 |
| The structural basis for peptide selection by the transport receptor OppA RPA Berntsson, MK Doeven, F Fusetti, RH Duurkens, D Sengupta, ... The EMBO journal 28 (9), 1332-1340, 2009 | 106 | 2009 |
| The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes MEM Noble, RK Wierenga, AM Lambeir, FR Opperdoes, ... Proteins: Structure, Function, and Bioinformatics 10 (1), 50-69, 1991 | 105 | 1991 |
| The catalytic domain of a bacterial lytic transglycosylase defines a novel class of lysozymes AMWH Thunnissen, NW Isaacs, BW Dijkstral Proteins: Structure, Function, and Bioinformatics 22 (3), 245-258, 1995 | 101 | 1995 |
| Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids H Raj, W Szymański, J De Villiers, HJ Rozeboom, VP Veetil, CR Reis, ... Nature Chemistry 4 (6), 478-484, 2012 | 97 | 2012 |
| Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases JY van der Meer, H Poddar, BJ Baas, Y Miao, M Rahimi, A Kunzendorf, ... Nature communications 7 (1), 10911, 2016 | 92 | 2016 |
| Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease AM Szperl, MR Golachowska, M Bruinenberg, R Prekeris, ... Journal of pediatric gastroenterology and nutrition 52 (3), 307-313, 2011 | 87 | 2011 |
| Directed evolution of a designer enzyme featuring an unnatural catalytic amino acid C Mayer, C Dulson, E Reddem, AMWH Thunnissen, G Roelfes Angewandte Chemie International Edition 58 (7), 2083-2087, 2019 | 85 | 2019 |
| Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold KE van Straaten, BW Dijkstra, W Vollmer, AMWH Thunnissen Journal of molecular biology 352 (5), 1068-1080, 2005 | 84 | 2005 |
| Explaining operational instability of amine transaminases: substrate-induced inactivation mechanism and influence of quaternary structure on enzyme–cofactor intermediate stability T Börner, S Rämisch, ER Reddem, S Bartsch, A Vogel, ... Acs Catalysis 7 (2), 1259-1269, 2017 | 71 | 2017 |
| Robust ω-transaminases by computational stabilization of the subunit interface Q Meng, N Capra, CM Palacio, E Lanfranchi, M Otzen, LZ Van Schie, ... ACS catalysis 10 (5), 2915-2928, 2020 | 69 | 2020 |
Driessen AJ*professor of molecular microbiologyPatvirtintas el. paštas rug.nl
