| Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage I Angulo, O Vadas, F Garçon, E Banham-Hall, V Plagnol, TR Leahy, ... Science 342 (6160), 866-871, 2013 | 670 | 2013 |
| Structural basis for activation and inhibition of class I phosphoinositide 3-kinases O Vadas, JE Burke, X Zhang, A Berndt, RL Williams Science signaling 4 (195), re2-re2, 2011 | 322 | 2011 |
| Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA) JE Burke, O Perisic, GR Masson, O Vadas, RL Williams Proceedings of the National Academy of Sciences 109 (38), 15259-15264, 2012 | 307 | 2012 |
| Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism X Zhang, O Vadas, O Perisic, KE Anderson, J Clark, PT Hawkins, ... Molecular cell 41 (5), 567-578, 2011 | 208 | 2011 |
| G protein–coupled receptor–mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness HA Dbouk, O Vadas, A Shymanets, JE Burke, RS Salamon, BD Khalil, ... Science signaling 5 (253), ra89-ra89, 2012 | 174 | 2012 |
| Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs) O Vadas, HA Dbouk, A Shymanets, O Perisic, JE Burke, WF Abi Saab, ... Proceedings of the National Academy of Sciences 110 (47), 18862-18867, 2013 | 160 | 2013 |
| Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α JE Burke, O Vadas, A Berndt, T Finegan, O Perisic, RL Williams Structure 19 (8), 1127-1137, 2011 | 119 | 2011 |
| Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1 GL Dornan, BD Siempelkamp, ML Jenkins, O Vadas, CL Lucas, JE Burke Proceedings of the National Academy of Sciences 114 (8), 1982-1987, 2017 | 112 | 2017 |
| Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma L Farrera-Soler, JP Daguer, S Barluenga, O Vadas, P Cohen, S Pagano, ... PloS one 15 (9), e0238089, 2020 | 91 | 2020 |
| Using hydrogen–deuterium exchange mass spectrometry to examine protein–membrane interactions O Vadas, ML Jenkins, GL Dornan, JE Burke Methods in enzymology 583, 143-172, 2017 | 69 | 2017 |
| Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange–MS (HDX–MS) O Vadas, JE Burke Biochemical Society Transactions 43 (5), 773-786, 2015 | 64 | 2015 |
| Autoregulation of class II alpha PI3K activity by its lipid-binding PX-C2 domain module H Wang, WT Lo, AV Žagar, F Gulluni, M Lehmann, L Scapozza, V Haucke, ... Molecular cell 71 (2), 343-351. e4, 2018 | 49 | 2018 |
| PI (3, 4) P2-mediated cytokinetic abscission prevents early senescence and cataract formation F Gulluni, L Prever, H Li, P Krafcikova, I Corrado, WT Lo, JP Margaria, ... Science 374 (6573), eabk0410, 2021 | 39 | 2021 |
| A coincidence detection mechanism controls PX-BAR domain-mediated endocytic membrane remodeling via an allosteric structural switch WT Lo, AV Žagar, F Gerth, M Lehmann, D Puchkov, O Krylova, C Freund, ... Developmental cell 43 (4), 522-529. e4, 2017 | 33 | 2017 |
| Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation MK Rathinaswamy, U Dalwadi, KD Fleming, C Adams, JTB Stariha, ... Science Advances 7 (35), eabj4282, 2021 | 32 | 2021 |
| Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa N Dos Santos Pacheco, L Brusini, R Haase, N Tosetti, B Maco, M Brochet, ... Nature Microbiology 7 (11), 1777-1790, 2022 | 31 | 2022 |
| Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of … A Shymanets, O Vadas, C Czupalla, J LoPiccolo, M Brenowitz, A Ghigo, ... Biochemical Journal 469 (1), 59-69, 2015 | 26 | 2015 |
| SUV39 SET domains mediate crosstalk of heterochromatic histone marks A Stirpe, N Guidotti, SJ Northall, S Kilic, A Hainard, O Vadas, B Fierz, ... Elife 10, e62682, 2021 | 25 | 2021 |
| Structural basis of phosphatidylinositol 3-kinase C2α function WT Lo, Y Zhang, O Vadas, Y Roske, F Gulluni, MC De Santis, AV Zagar, ... Nature Structural & Molecular Biology 29 (3), 218-228, 2022 | 24 | 2022 |
| Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion G Lentini, R Ben Chaabene, O Vadas, C Ramakrishnan, B Mukherjee, ... Nature Communications 12 (1), 3788, 2021 | 22 | 2021 |
