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Klaus Rytved
Klaus Rytved
Principal Scientist, Predicitive Toxicology
Verified email at leo-pharma.com
Title
Cited by
Cited by
Year
Fragment-based discovery of 6-arylindazole JAK inhibitors
A Ritzén, MD Sørensen, KN Dack, DR Greve, A Jerre, MA Carnerup, ...
ACS Medicinal Chemistry Letters 7 (6), 641-646, 2016
242016
Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
K Rytved, N Dragsted, N Nyborg, L Iversen, M Kristiansen
US Patent App. 10/429,625, 2004
242004
Prostaglandin E2 release from dermis regulates sodium permeability of frog skin epithelium
KA Rytved, B Brodin, R Nielsen
Acta physiologica scandinavica 153 (3), 263-270, 1995
221995
An increase in [Ca2+]i activates basolateral chloride channels and inhibits apical sodium channels in frog skin epithelium
B Brodin, KA Rytved, R Nielsen
Pflügers Archiv 433, 16-25, 1996
201996
EP3 receptors inhibit antidiuretic-hormone-dependent sodium transport across frog skin epithelium
KA Rytved, R Nielsen
Pflügers Archiv 437, 213-218, 1999
101999
Intracellular calcium modulates basolateral K+-permeability in frog skin epithelium
B Brodin, KA Rytved, R Nielsen
Pflügers Archiv 426, 171-173, 1994
101994
Prostaglandin E2 inhibits antidiuretic hormone induced transepithelial sodium transport and cAMP production in frog skin epithelium (Rana esculenta)
KA Rytved, H Andersen, R Nielsen
Acta physiologica scandinavica 158 (4), 357-363, 1996
61996
Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
K Rytved, N Dragsted, N Nyborg, L Iversen, M Kristiansen
US Patent App. 10/943,548, 2005
42005
Non-linear mixed effects modeling of sparse concentration data from rats: Application to a glycogen phosphorylase inhibitor
SH Ingwersen, B Kiehr, L Iversen, MP Andersen, Y Petersen, KA Rytved
European journal of drug metabolism and pharmacokinetics 27, 203-212, 2002
32002
Outward rectifying chloride channels in the basolateral membrane of frog skin epithelium. A patch clamp study
KA Rytved, B Brodin, R Nielsen
Acta physiol. scand 153, 263-270, 1996
21996
P04-19 Selecting drug like structures using in silico tools
KA Rytved, M Joergensen, MJ De Groot, MD Soerensen, M Egebjerg, ...
Toxicology Letters 368, S106, 2022
2022
A cold-hearted guinea pig: cardiovascular toxicity elucidated using in vivo and ex vivo models
KA Rytved, MD Soerensen, K Maansson, FL Egerod, P Johnson, ...
TOXICOLOGY LETTERS 314, S169-S170, 2019
2019
Effects of temperature changes on left ventricular cardiac functions and cardiac electrical activity parameters of guinea-pig isolated perfused heart
H Didier, C Salvetat, S Guilbot, KA Rytved, R Printemps, M Le Grand
Journal of Pharmacological and Toxicological Methods 99, 106595, 2019
2019
032 An advanced biology platform to guide the discovery of a new highly selective JAK1 inhibitor for atopic dermatitis treatment
P Lovato, J Felding, J Larsen, LK Rasmussen, A Ritzen, K Rytved, ...
Journal of Investigative Dermatology 139 (9), S220, 2019
2019
Telemetry in the guinea-pig: A model for early safety evaluation of both haemodynamic and electrocardiographic parameters
E Delpy, KA Rytved, ED Christoffersen, AK Lykkeberg, KG Madsen, ...
Journal of Pharmacological and Toxicological Methods 2 (62), e43, 2010
2010
Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
KA Rytved, N Dragsted, NCB Nyborg, L Iversen, M Kristiansen
US Patent 6,960,610, 2005
2005
Inhibition of myocardial glycogen phosphorylase reduces infarct size following a global ischemic period in anesthetized rabbits
N Nyborg, B Kiehr, K Fosgerau, K Rytved
DIABETES 52, A163-A163, 2003
2003
Inhibition of glycogen phosphorylase prevents arrhytmia following a global ischemic period in the perfused rabbit heart
K Fosgerau, N Nyborg, I Sjogren, K Rytved
DIABETES 52, A154-A154, 2003
2003
NN414 potently inhibits beta-cell function without affecting cardiovascular function
HCM Boonen, POG Arkhammar, JB Hansen, KA Rytved, A Worsaae
DIABETES 51, A387-A387, 2002
2002
PGE2 inhibits ADH induced Na+ transport and cAMP production in frog skin.
KA Rytved, H Andersen, R Nielsen
Pflügers Archiv: European Journal of Physiology, 1995
1995
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Articles 1–20