Testing Racemic Chiral Catalysts for Kinetic Resolution Potential. B Dominguez, NS Hodnett, GC Lloyd-Jones Angewandte Chemie (International ed. in English) 40 (22), 4289-4291, 2001 | 57 | 2001 |
High-throughput automated design of experiment (DoE) and kinetic modeling to aid in process development of an API C Nunn, A DiPietro, N Hodnett, P Sun, KM Wells Organic Process Research & Development 22 (1), 54-61, 2018 | 54 | 2018 |
A catalytic asymmetric bioorganic route to enantioenriched tetrahydro-and dihydropyranones C Baker-Glenn, N Hodnett, M Reiter, S Ropp, R Ancliff, V Gouverneur Journal of the American Chemical Society 127 (5), 1481-1486, 2005 | 46 | 2005 |
Kinetic model development for accelerated stability studies D Clancy, N Hodnett, R Orr, M Owen, J Peterson AAPS PharmSciTech 18 (4), 1158-1176, 2017 | 41 | 2017 |
Mechanistic implications of pseudo zero order kinetics in kinetic resolutions DG Blackmond, NS Hodnett, GC Lloyd-Jones Journal of the American Chemical Society 128 (23), 7450-7451, 2006 | 36 | 2006 |
Trimethylsilyldiazomethane NS Hodnett Synlett 2003 (13), 2095-2096, 2003 | 19 | 2003 |
Identification and characterisation of a salt form of Danirixin with reduced pharmacokinetic variability in patient populations JC Bloomer, C Ambery, BE Miller, P Connolly, H Garden, N Henley, ... European Journal of Pharmaceutics and Biopharmaceutics 117, 224-231, 2017 | 17 | 2017 |
ZUSCHRIFTEN-Testing Racemic Chiral Catalysts for Kinetic Resolution Potential B Dominguez, NS Hodnett, GC Lloyd-Jones Angewandte Chemie-German Edition 113 (22), 4419-4422, 2001 | 17 | 2001 |
The Even‐Handed Approach: Strategies for the Deployment of Racemic Chiral Catalysts LA Evans, NS Hodnett, GC Lloyd‐Jones Angewandte Chemie International Edition 51 (7), 1526-1533, 2012 | 11 | 2012 |
Development and Scale-Up of a Manufacturing Route for the Non-nucleoside Reverse Transcriptase Inhibitor GSK2248761A (IDX-899): Synthesis of an Advanced Key Chiral Intermediate R Bellingham, G Borrett, G Bret, B Choudary, D Colclough, J Hayes, ... Organic Process Research & Development 22 (2), 200-206, 2018 | 9 | 2018 |
Predictive distributions for constructing the ICH Q8 design space JJ Peterson, M Yahyah, K Lief, N Hodnett Comprehensive Quality by Design for Pharmaceutical Product Development and …, 2017 | 9 | 2017 |
Application of a system model for continuous manufacturing of an active pharmaceutical ingredient in an industrial environment S Diab, G Bano, C Christodoulou, N Hodnett, A Benedetti, M Andersson, ... Journal of Pharmaceutical Innovation 17 (4), 1333-1346, 2022 | 7 | 2022 |
Computer vision for non-contact monitoring of catalyst degradation and product formation kinetics C Yan, M Cowie, C Howcutt, KMP Wheelhouse, NS Hodnett, M Kollie, ... Chemical Science 14 (20), 5323-5331, 2023 | 6 | 2023 |
Development of a Scalable Process for the PPAR-α Agonist GW641597X Incorporating Baeyer–Villiger Chemistry and Retrospective ICH M7 Assessment T Boyer, BM Choudary, AJ Edwards, E Etridge, S Etridge, A Giddings, ... Organic Process Research & Development 24 (3), 371-386, 2020 | 4 | 2020 |
Computer vision for understanding catalyst degradation kinetics C Yan, M Cowie, C Howcutt, K Wheelhouse, N Hodnett, M Kollie, ... | 3 | 2022 |
Investigation of a Weak Temperature–Rate Relationship in the Carbamoylation of a Barbituric Acid Pharmaceutical Intermediate AG O’Brien, YC Liu, MJ Hughes, JJ Lim, NS Hodnett, N Falco The Journal of Organic Chemistry 84 (8), 4948-4952, 2019 | 3 | 2019 |
Development of an Efficient Manufacturing Process to GSK2248761A API C Bret, E Smith, E Vit, JF Hayes, JD Hayler, A Ironmonger, D Pascoe, ... Organic Process Research & Development 22 (2), 207-211, 2018 | 2 | 2018 |
Der “unparteiische” Ansatz: Strategien zur Entwicklung von racemischen chiralen Katalysatoren LA Evans, NS Hodnett, GC Lloyd‐Jones Angewandte Chemie 124 (7), 1556-1564, 2012 | 2 | 2012 |
Kinetic barriers to disproportionation of salts of weakly basic drugs T Van Duong, S Diab, NS Hodnett, LS Taylor Molecular Pharmaceutics 20 (8), 3886-3894, 2023 | 1 | 2023 |
The Integration of Drug Substance and Drug Product Manufacturing Models: The Missing Link for Model-based End-to-End Process Development C Christodoulou, S Diab, G Bano, M Aroniada, N Hodnett, S Zomer Computer Aided Chemical Engineering 52, 2101-2106, 2023 | | 2023 |