| An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery GR Masson, ML Jenkins, JE Burke Expert opinion on drug discovery 12 (10), 981-994, 2017 | 167 | 2017 |
| Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1 GL Dornan, BD Siempelkamp, ML Jenkins, O Vadas, CL Lucas, JE Burke Proceedings of the National Academy of Sciences 114 (8), 1982-1987, 2017 | 112 | 2017 |
| Ras binder induces a modified switch-II pocket in GTP and GDP states DR Gentile, MK Rathinaswamy, ML Jenkins, SM Moss, BD Siempelkamp, ... Cell chemical biology 24 (12), 1455-1466. e14, 2017 | 107 | 2017 |
| Recognition of protein-linked glycans as a determinant of peptidase activity I Noach, E Ficko-Blean, B Pluvinage, C Stuart, ML Jenkins, D Brochu, ... Proceedings of the National Academy of Sciences 114 (5), E679-E688, 2017 | 90 | 2017 |
| Expanding the scope of electrophiles capable of targeting K-Ras oncogenes LM McGregor, ML Jenkins, C Kerwin, JE Burke, KM Shokat Biochemistry 56 (25), 3178-3183, 2017 | 83 | 2017 |
| Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans AJ Takeda, Y Zhang, GL Dornan, BD Siempelkamp, ML Jenkins, ... Journal of Allergy and Clinical Immunology 140 (4), 1152-1156. e10, 2017 | 75 | 2017 |
| Using hydrogen–deuterium exchange mass spectrometry to examine protein–membrane interactions O Vadas, ML Jenkins, GL Dornan, JE Burke Methods in enzymology 583, 143-172, 2017 | 69 | 2017 |
| Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas BD Siempelkamp, MK Rathinaswamy, ML Jenkins, JE Burke Journal of Biological Chemistry 292 (29), 12256-12266, 2017 | 68 | 2017 |
| Molecular basis for recognition of the cancer glycobiomarker, LacdiNAc (GalNAc [β1→ 4] GlcNAc), by Wisteria floribunda Agglutinin O Haji-Ghassemi, M Gilbert, J Spence, MJ Schur, MJ Parker, ML Jenkins, ... Journal of Biological Chemistry 291 (46), 24085-24095, 2016 | 64 | 2016 |
| Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-l-fucosidases from GH29 C Vickers, F Liu, K Abe, O Salama-Alber, M Jenkins, CMK Springate, ... Journal of Biological Chemistry 293 (47), 18296-18308, 2018 | 58 | 2018 |
| Novel K-Ras G12C switch-II covalent binders destabilize Ras and accelerate nucleotide exchange CI Nnadi, ML Jenkins, DR Gentile, LA Bateman, D Zaidman, TE Balius, ... Journal of chemical information and modeling 58 (2), 464-471, 2018 | 53 | 2018 |
| The molecular basis of Aichi virus 3A protein activation of phosphatidylinositol 4 kinase IIIβ, PI4KB, through ACBD3 JA McPhail, EH Ottosen, ML Jenkins, JE Burke Structure 25 (1), 121-131, 2017 | 49 | 2017 |
| Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 ML Fowler, JA McPhail, ML Jenkins, GR Masson, FU Rutaganira, ... Protein Science 25 (4), 826-839, 2016 | 49 | 2016 |
| Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 ML Jenkins, JP Margaria, JTB Stariha, RM Hoffmann, JA McPhail, ... Nature Communications 9 (1), 3772, 2018 | 42 | 2018 |
| An intrinsic lipid-binding interface controls sphingosine kinase 1 function [S] MJ Pulkoski-Gross, ML Jenkins, JP Truman, MF Salama, CJ Clarke, ... Journal of lipid research 59 (3), 462-474, 2018 | 37 | 2018 |
| Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication JA McPhail, H Lyoo, JG Pemberton, RM Hoffmann, W van Elst, ... EMBO reports 21 (2), e48441, 2020 | 36 | 2020 |
| Escherichia coli and Sf9 Contaminant Databases to Increase Efficiency of Tandem Mass Spectrometry Peptide Identification in Structural Mass Spectrometry … JM Dobbs, ML Jenkins, JE Burke Journal of the American Society for Mass Spectrometry 31 (10), 2202-2209, 2020 | 28 | 2020 |
| Activation of phospholipase C β by Gβγ and Gαq involves C-terminal rearrangement to release autoinhibition IJ Fisher, ML Jenkins, GG Tall, JE Burke, AV Smrcka Structure 28 (7), 810-819. e5, 2020 | 27 | 2020 |
| Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane I Ulengin-Talkish, MAH Parson, ML Jenkins, J Roy, AZL Shih, N St-Denis, ... Nature communications 12 (1), 6064, 2021 | 26 | 2021 |
| The substrate specificity of the human TRAPPII complex’s Rab-guanine nucleotide exchange factor activity ML Jenkins, NJ Harris, U Dalwadi, KD Fleming, DS Ziemianowicz, ... Communications Biology 3 (1), 735, 2020 | 24 | 2020 |
John E BurkeProfessor of Biochemistry and Microbiology, University of VictoriaVerified email at uvic.ca
