J. Fernando Díaz
J. Fernando Díaz
Investigador Científico, Centro de Investigaciones Biológicas CSIC.
Verified email at - Homepage
Cited by
Cited by
Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition
JF Diaz, JM Andreu
Biochemistry 32 (11), 2747-2755, 1993
Molecular mechanism of action of microtubule-stabilizing anticancer agents
AE Prota, K Bargsten, D Zurwerra, JJ Field, JF Díaz, KH Altmann, ...
Science 339 (6119), 587-590, 2013
Low-resolution structures of proteins in solution retrieved from X-ray scattering with a genetic algorithm
P Chacon, F Moran, JF Diaz, E Pantos, JM Andreu
Biophysical Journal 74 (6), 2760-2775, 1998
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for …
DE Pryor, A O'Brate, G Bilcer, JF Díaz, Y Wang, Y Wang, M Kabaki, ...
Biochemistry 41 (29), 9109-9115, 2002
Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines
TN Gaitanos, RM Buey, JF Díaz, PT Northcote, P Teesdale-Spittle, ...
Cancer research 64 (15), 5063-5067, 2004
Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity
RM Buey, I Barasoain, E Jackson, A Meyer, P Giannakakou, I Paterson, ...
Chemistry & biology 12 (12), 1269-1279, 2005
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
AE Prota, K Bargsten, JF Diaz, M Marsh, C Cuevas, M Liniger, C Neuhaus, ...
Proceedings of the National Academy of Sciences 111 (38), 13817-13821, 2014
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure− activity relationships and molecular modeling studies
G La Regina, MC Edler, A Brancale, S Kandil, A Coluccia, F Piscitelli, ...
Journal of medicinal chemistry 50 (12), 2865-2874, 2007
Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures
EH Kellogg, NMA Hejab, S Howes, P Northcote, JH Miller, JF Díaz, ...
Journal of molecular biology 429 (5), 633-646, 2017
Structural basis of microtubule stabilization by laulimalide and peloruside A
AE Prota, K Bargsten, PT Northcote, M Marsh, KH Altmann, JH Miller, ...
Angewandte Chemie International Edition 53 (6), 1621-1625, 2014
Low resolution structure of microtubules in solution: Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in …
JM Andreu, J Bordas, JF Diaz, JG de Ancos, R Gil, FJ Medrano, ...
Journal of molecular biology 226 (1), 169-184, 1992
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
RM Buey, E Calvo, I Barasoain, O Pineda, MC Edler, R Matesanz, ...
Nature chemical biology 3 (2), 117-125, 2007
Molecular recognition of taxol by microtubules: kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site
JF Dıaz, R Strobe, Y Engelborghs, AA Souto, JM Andreu
Journal of Biological Chemistry 275 (34), 26265-26276, 2000
Changes in microtubule protofilament number induced by taxol binding to an easily accessible site: internal microtubule dynamics
JF Dıaz, JM Valpuesta, P Chacón, G Diakun, JM Andreu
Journal of Biological Chemistry 273 (50), 33803-33810, 1998
Reconstruction of protein form with X-ray solution scattering and a genetic algorithm
P Chacón, JF Dıaz, F Morán, JM Andreu
Journal of molecular biology 299 (5), 1289-1302, 2000
The susceptibility of pure tubulin to high magnetic fields: a magnetic birefringence and x-ray fiber diffraction study
W Bras, GP Diakun, JF Diaz, G Maret, H Kramer, J Bordas, FJ Medrano
Biophysical journal 74 (3), 1509-1521, 1998
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity
RM Buey, JF Dı́az, JM Andreu, A O'Brate, P Giannakakou, KC Nicolaou, ...
Chemistry & biology 11 (2), 225-236, 2004
Fast kinetics of Taxol binding to microtubules: effects of solution variables and microtubule-associated proteins
JF Dıaz, I Barasoain, JM Andreu
Journal of Biological Chemistry 278 (10), 8407-8419, 2003
Thermodynamics of ligand-induced assembly of tubulin
JF Diaz, M Menendez, JM Andreu
Biochemistry 32 (38), 10067-10077, 1993
The binding sites of microtubule-stabilizing agents
JJ Field, JF Díaz, JH Miller
Chemistry & biology 20 (3), 301-315, 2013
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