| Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition JF Diaz, JM Andreu Biochemistry 32 (11), 2747-2755, 1993 | 542 | 1993 |
| Molecular mechanism of action of microtubule-stabilizing anticancer agents AE Prota, K Bargsten, D Zurwerra, JJ Field, JF Díaz, KH Altmann, ... Science 339 (6119), 587-590, 2013 | 479 | 2013 |
| Low-resolution structures of proteins in solution retrieved from X-ray scattering with a genetic algorithm P Chacon, F Moran, JF Diaz, E Pantos, JM Andreu Biophysical Journal 74 (6), 2760-2775, 1998 | 348 | 1998 |
| The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for … DE Pryor, A O'Brate, G Bilcer, JF Díaz, Y Wang, Y Wang, M Kabaki, ... Biochemistry 41 (29), 9109-9115, 2002 | 305 | 2002 |
| Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines TN Gaitanos, RM Buey, JF Díaz, PT Northcote, P Teesdale-Spittle, ... Cancer research 64 (15), 5063-5067, 2004 | 251 | 2004 |
| Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity RM Buey, I Barasoain, E Jackson, A Meyer, P Giannakakou, I Paterson, ... Chemistry & biology 12 (12), 1269-1279, 2005 | 249 | 2005 |
| A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs AE Prota, K Bargsten, JF Diaz, M Marsh, C Cuevas, M Liniger, C Neuhaus, ... Proceedings of the National Academy of Sciences 111 (38), 13817-13821, 2014 | 234 | 2014 |
| Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure− activity relationships and molecular modeling studies G La Regina, MC Edler, A Brancale, S Kandil, A Coluccia, F Piscitelli, ... Journal of medicinal chemistry 50 (12), 2865-2874, 2007 | 203 | 2007 |
| Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures EH Kellogg, NMA Hejab, S Howes, P Northcote, JH Miller, JF Díaz, ... Journal of molecular biology 429 (5), 633-646, 2017 | 182 | 2017 |
| Structural basis of microtubule stabilization by laulimalide and peloruside A AE Prota, K Bargsten, PT Northcote, M Marsh, KH Altmann, JH Miller, ... Angewandte Chemie International Edition 53 (6), 1621-1625, 2014 | 180 | 2014 |
| Low resolution structure of microtubules in solution: Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in … JM Andreu, J Bordas, JF Diaz, JG de Ancos, R Gil, FJ Medrano, ... Journal of molecular biology 226 (1), 169-184, 1992 | 178 | 1992 |
| Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites RM Buey, E Calvo, I Barasoain, O Pineda, MC Edler, R Matesanz, ... Nature chemical biology 3 (2), 117-125, 2007 | 174 | 2007 |
| Molecular recognition of taxol by microtubules: kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site JF Dıaz, R Strobe, Y Engelborghs, AA Souto, JM Andreu Journal of Biological Chemistry 275 (34), 26265-26276, 2000 | 171 | 2000 |
| Changes in microtubule protofilament number induced by taxol binding to an easily accessible site: internal microtubule dynamics JF Dıaz, JM Valpuesta, P Chacón, G Diakun, JM Andreu Journal of Biological Chemistry 273 (50), 33803-33810, 1998 | 168 | 1998 |
| Reconstruction of protein form with X-ray solution scattering and a genetic algorithm P Chacón, JF Dıaz, F Morán, JM Andreu Journal of molecular biology 299 (5), 1289-1302, 2000 | 156 | 2000 |
| The susceptibility of pure tubulin to high magnetic fields: a magnetic birefringence and x-ray fiber diffraction study W Bras, GP Diakun, JF Diaz, G Maret, H Kramer, J Bordas, FJ Medrano Biophysical journal 74 (3), 1509-1521, 1998 | 151 | 1998 |
| Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity RM Buey, JF Dı́az, JM Andreu, A O'Brate, P Giannakakou, KC Nicolaou, ... Chemistry & biology 11 (2), 225-236, 2004 | 150 | 2004 |
| Fast kinetics of Taxol binding to microtubules: effects of solution variables and microtubule-associated proteins JF Dıaz, I Barasoain, JM Andreu Journal of Biological Chemistry 278 (10), 8407-8419, 2003 | 141 | 2003 |
| Thermodynamics of ligand-induced assembly of tubulin JF Diaz, M Menendez, JM Andreu Biochemistry 32 (38), 10067-10077, 1993 | 128 | 1993 |
| The binding sites of microtubule-stabilizing agents JJ Field, JF Díaz, JH Miller Chemistry & biology 20 (3), 301-315, 2013 | 124 | 2013 |
José Manuel AndreuCentro de Investigaciones Biologicas Margarita Salas CSIC Madrid, SpainVerified email at cib.csic.es
