Jared Toettcher
Jared Toettcher
Associate Professor, Princeton University
Verified email at - Homepage
Cited by
Cited by
Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets
Y Shin, J Berry, N Pannucci, MP Haataja, JE Toettcher, CP Brangwynne
Cell 168 (1), 159-171. e14, 2017
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
LS Weinberger, JC Burnett, JE Toettcher, AP Arkin, DV Schaffer
Cell 122 (2), 169-182, 2005
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module
JE Toettcher, OD Weiner, WA Lim
Cell 155 (6), 1422-1434, 2013
Mapping local and global liquid phase behavior in living cells using photo-oligomerizable seeds
D Bracha, MT Walls, MT Wei, L Zhu, M Kurian, JL Avalos, JE Toettcher, ...
Cell 175 (6), 1467-1480. e13, 2018
Optogenetic regulation of engineered cellular metabolism for microbial chemical production
EM Zhao, Y Zhang, J Mehl, H Park, MA Lalwani, JE Toettcher, JL Avalos
Nature 555 (7698), 683-687, 2018
Four key steps control glycolytic flux in mammalian cells
LB Tanner, AG Goglia, MH Wei, T Sehgal, LR Parsons, JO Park, E White, ...
Cell systems 7 (1), 49-62. e8, 2018
Light-based feedback for controlling intracellular signaling dynamics
JE Toettcher, D Gong, WA Lim, OD Weiner
Nature methods 8 (10), 837-839, 2011
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time
JE Toettcher, CA Voigt, OD Weiner, WA Lim
Nature methods 8 (1), 35-38, 2011
Light-based control of metabolic flux through assembly of synthetic organelles
EM Zhao, N Suek, MZ Wilson, E Dine, NL Pannucci, Z Gitai, JL Avalos, ...
Nature chemical biology 15 (6), 589-597, 2019
The spatiotemporal limits of developmental Erk signaling
HE Johnson, Y Goyal, NL Pannucci, T Schüpbach, SY Shvartsman, ...
Developmental cell 40 (2), 185-192, 2017
Protein phase separation provides long-term memory of transient spatial stimuli
E Dine, AA Gil, G Uribe, CP Brangwynne, JE Toettcher
Cell systems 6 (6), 655-663. e5, 2018
Tracing information flow from Erk to target gene induction reveals mechanisms of dynamic and combinatorial control
MZ Wilson, PT Ravindran, WA Lim, JE Toettcher
Molecular cell 67 (5), 757-769. e5, 2017
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
LJ Bugaj, AJ Sabnis, A Mitchell, JE Garbarino, JE Toettcher, TG Bivona, ...
Science 361 (6405), eaao3048, 2018
Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus …
BA Diner, KK Lum, JE Toettcher, IM Cristea
MBio 7 (6), 10.1128/mbio. 01553-16, 2016
Distinct mechanisms act in concert to mediate cell cycle arrest
JE Toettcher, A Loewer, GJ Ostheimer, MB Yaffe, B Tidor, G Lahav
Proceedings of the National Academy of Sciences 106 (3), 785-790, 2009
Optogenetic control of protein binding using light-switchable nanobodies
AA Gil, C Carrasco-López, L Zhu, EM Zhao, PT Ravindran, MZ Wilson, ...
Nature communications 11 (1), 4044, 2020
Signaling dynamics control cell fate in the early Drosophila embryo
HE Johnson, JE Toettcher
Developmental cell 48 (3), 361-370. e3, 2019
Stimulus design for model selection and validation in cell signaling
JF Apgar, JE Toettcher, D Endy, FM White, B Tidor
PLoS computational biology 4 (2), e30, 2008
A bright future: optogenetics to dissect the spatiotemporal control of cell behavior
AG Goglia, JE Toettcher
Current opinion in chemical biology 48, 106-113, 2019
A synthetic–natural hybrid oscillator in human cells
JE Toettcher, C Mock, E Batchelor, A Loewer, G Lahav
Proceedings of the National Academy of Sciences 107 (39), 17047-17052, 2010
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