Adam Lesner
Adam Lesner
Wydział Chemii, Uniwersytet Gdański
Patvirtintas el. paštas
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
P Kosikowska, A Lesner
Expert opinion on therapeutic patents 26 (6), 689-702, 2016
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
J Hahn, C Schauer, C Czegley, L Kling, L Petru, B Schmid, D Weidner, ...
The FASEB Journal 33 (1), 1401, 2019
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
B Korkmaz, GH Caughey, I Chapple, F Gauthier, J Hirschfeld, DE Jenne, ...
Pharmacology & therapeutics 190, 202-236, 2018
Fecal serine protease profiling in inflammatory bowel diseases
A Jablaoui, A Kriaa, H Mkaouar, N Akermi, S Soussou, M Wysocka, ...
Frontiers in cellular and infection microbiology 10, 21, 2020
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)
B Korkmaz, A Lesner, S Letast, YK Mahdi, ML Jourdan, S Dallet-Choisy, ...
Seminars in immunopathology 35, 411-421, 2013
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery
A Lesner, A Legowska, M Wysocka, K Rolka
Current pharmaceutical design 17 (38), 4308-4317, 2011
Lung protection by cathepsin C inhibition: A new hope for COVID-19 and ARDS? Miniperspective
B Korkmaz, A Lesner, S Marchand-Adam, C Moss, DE Jenne
Journal of Medicinal Chemistry 63 (22), 13258-13265, 2020
Substrate profiling of Zika virus NS 2B‐NS 3 protease
N Gruba, JI Rodriguez Martinez, R Grzywa, M Wysocka, M Skoreński, ...
FEBS letters 590 (20), 3459-3468, 2016
Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors
A Łęgowska, D Dębowski, A Lesner, M Wysocka, K Rolka
Bioorganic & medicinal chemistry 17 (9), 3302-3307, 2009
Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases
Y Hamon, M Legowska, V Hervé, S Dallet-Choisy, S Marchand-Adam, ...
Journal of Biological Chemistry 291 (16), 8486-8499, 2016
Myeloperoxidase modulates inflammation in generalized pustular psoriasis and additional rare pustular skin diseases
S Haskamp, H Bruns, M Hahn, M Hoffmann, A Gregor, S Löhr, J Hahn, ...
The American Journal of Human Genetics 107 (3), 527-538, 2020
Structural and functional analysis of human HtrA3 protease and its subdomains
P Glaza, J Osipiuk, T Wenta, D Zurawa-Janicka, M Jarzab, A Lesner, ...
PloS one 10 (6), e0131142, 2015
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
J Wang, S Sjöberg, TT Tang, K Öörni, W Wu, C Liu, B Secco, V Tia, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (11 …, 2014
Biochemical and structural characterization of SplD protease from Staphylococcus aureus
M Zdzalik, M Kalinska, M Wysocka, J Stec-Niemczyk, P Cichon, N Stach, ...
PLoS One 8 (10), e76812, 2013
Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
C Guarino, Y Hamon, C Croix, AS Lamort, S Dallet-Choisy, ...
Biochemical Pharmacology 131, 52-67, 2017
New selective peptidyl di (chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases
C Guarino, M Legowska, C Epinette, C Kellenberger, S Dallet-Choisy, ...
Journal of Biological Chemistry 289 (46), 31777-31791, 2014
Temperature-induced changes of HtrA2 (Omi) protease activity and structure
D Zurawa-Janicka, M Jarzab, A Polit, J Skorko-Glonek, A Lesner, A Gitlin, ...
Cell Stress and Chaperones 18, 35-51, 2013
Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI‐1 as a starting structure
E Zabłotna, A Jaśkiewicz, A Łęgowska, H Miecznikowska, A Lesner, ...
Journal of peptide science: an official publication of the European Peptide …, 2007
Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
A Lesner, R Shilpi, A Ivanova, MA Gawinowicz, J Lesniak, D Nikolov, ...
Biochemical and biophysical research communications 389 (2), 284-289, 2009
Design of selective substrates of proteinase 3 using combinatorial chemistry methods
M Wysocka, A Lesner, K Guzow, L Mackiewicz, A Łęgowska, W Wiczk, ...
Analytical biochemistry 378 (2), 208-215, 2008
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Straipsniai 1–20