| A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs AE Prota, K Bargsten, JF Diaz, M Marsh, C Cuevas, M Liniger, C Neuhaus, ... Proceedings of the National Academy of Sciences 111 (38), 13817-13821, 2014 | 265 | 2014 |
| An automated microseed matrix-screening method for protein crystallization A D'Arcy, F Villard, M Marsh Acta Crystallographica Section D: Biological Crystallography 63 (4), 550-554, 2007 | 256 | 2007 |
| Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons T Weinert, N Olieric, R Cheng, S Brünle, D James, D Ozerov, D Gashi, ... Nature communications 8 (1), 542, 2017 | 245 | 2017 |
| Structural basis of microtubule stabilization by laulimalide and peloruside A AE Prota, K Bargsten, PT Northcote, M Marsh, KH Altmann, JH Miller, ... Angewandte Chemie International Edition 53 (6), 1621-1625, 2014 | 200 | 2014 |
| Microseed matrix screening for optimization in protein crystallization: what have we learned? A D'Arcy, T Bergfors, SW Cowan-Jacob, M Marsh Acta Crystallographica Section F: Structural Biology Communications 70 (9 …, 2014 | 151 | 2014 |
| Using a fragment‐based approach to target protein–protein interactions DE Scott, MT Ehebauer, T Pukala, M Marsh, TL Blundell, ... ChemBioChem 14 (3), 332-342, 2013 | 141 | 2013 |
| Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery A Winter, AP Higueruelo, M Marsh, A Sigurdardottir, WR Pitt, TL Blundell Quarterly reviews of biophysics 45 (4), 383-426, 2012 | 129 | 2012 |
| Targeting protein–protein interactions and fragment-based drug discovery E Valkov, T Sharpe, M Marsh, S Greive, M Hyvönen Fragment-Based Drug Discovery and X-Ray Crystallography, 145-179, 2012 | 122 | 2012 |
| An enantioselective artificial Suzukiase based on the biotin–streptavidin technology A Chatterjee, H Mallin, J Klehr, J Vallapurackal, AD Finke, L Vera, ... Chemical science 7 (1), 673-677, 2016 | 108 | 2016 |
| Structural basis for− 10 promoter element melting by environmentally induced sigma factors S Campagne, ME Marsh, G Capitani, JA Vorholt, FHT Allain Nature structural & molecular biology 21 (3), 269-276, 2014 | 89 | 2014 |
| Thermodynamic properties of water molecules at a protein–protein interaction surface DJ Huggins, M Marsh, MC Payne Journal of chemical theory and computation 7 (11), 3514-3522, 2011 | 55 | 2011 |
| Comprehensive analysis of binding sites in tubulin T Mühlethaler, D Gioia, AE Prota, ME Sharpe, A Cavalli, MO Steinmetz Angewandte Chemie 133 (24), 13443-13454, 2021 | 51 | 2021 |
| NMR-based determination of the 3D structure of the ligand–protein interaction site without protein resonance assignment J Orts, MA Wälti, M Marsh, L Vera, AD Gossert, P Güntert, R Riek Journal of the American Chemical Society 138 (13), 4393-4400, 2016 | 47 | 2016 |
| Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain X Ni, M Schröder, V Olieric, ME Sharpe, V Hernandez-Olmos, ... ACS medicinal chemistry letters 12 (4), 603-609, 2021 | 37 | 2021 |
| Crystal structures of fungal tectonin in complex with O-methylated glycans suggest key role in innate immune defense R Sommer, ON Makshakova, T Wohlschlager, S Hutin, M Marsh, A Titz, ... Structure 26 (3), 391-402. e4, 2018 | 34 | 2018 |
| Structural and Spectroscopic Consequences of Hexacoordination of a Bacteriochlorophyll Cofactor in the Rhodobacter sphaeroides Reaction Center, D Frolov, M Marsh, LI Crouch, PK Fyfe, B Robert, R van Grondelle, ... Biochemistry 49 (9), 1882-1892, 2010 | 31 | 2010 |
| Advances in long-wavelength native phasing at X-ray free-electron lasers K Nass, R Cheng, L Vera, A Mozzanica, S Redford, D Ozerov, S Basu, ... IUCrJ 7 (6), 965-975, 2020 | 28 | 2020 |
| Combining high‐throughput synthesis and high‐throughput protein crystallography for accelerated hit identification F Sutanto, S Shaabani, R Oerlemans, D Eris, P Patil, M Hadian, M Wang, ... Angewandte Chemie 133 (33), 18379-18387, 2021 | 27 | 2021 |
| A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, ... Cell chemical biology 28 (6), 835-847. e5, 2021 | 27 | 2021 |
| Structure of bacterial glutathione-S-transferase maleyl pyruvate isomerase and implications for mechanism of isomerisation M Marsh, DK Shoemark, A Jacob, C Robinson, B Cahill, NY Zhou, ... Journal of molecular biology 384 (1), 165-177, 2008 | 26 | 2008 |
