Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture CK Savile, JM Janey, EC Mundorff, JC Moore, S Tam, WR Jarvis, ... Science 329 (5989), 305-309, 2010 | 2000 | 2010 |
Improving catalytic function by ProSAR-driven enzyme evolution RJ Fox, SC Davis, EC Mundorff, LM Newman, V Gavrilovic, SK Ma, ... Nature biotechnology 25 (3), 338-344, 2007 | 700 | 2007 |
Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently JE Ness, S Kim, A Gottman, R Pak, A Krebber, TV Borchert, ... Nature biotechnology 20 (12), 1251-1255, 2002 | 296 | 2002 |
Development of a biocatalytic process as an alternative to the (−)-DIP-Cl-mediated asymmetric reduction of a key intermediate of montelukast J Liang, J Lalonde, B Borup, V Mitchell, E Mundorff, N Trinh, ... Organic Process Research & Development 14 (1), 193-198, 2010 | 273 | 2010 |
Evolutionary potential of (β/α) 8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily DMZ Schmidt, EC Mundorff, M Dojka, E Bermudez, JE Ness, ... Biochemistry 42 (28), 8387-8393, 2003 | 232 | 2003 |
Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol J Liang, E Mundorff, R Voladri, S Jenne, L Gilson, A Conway, A Krebber, ... Organic Process Research & Development 14 (1), 188-192, 2010 | 141 | 2010 |
Optimization of crossover points for directed evolution EC Mundorff, S Govindarajan, C Gustafsson, JS Minshull US Patent 7,620,500, 2009 | 130 | 2009 |
The interplay between binding energy and catalysis in the evolution of a catalytic antibody HD Ulrich, E Mundorff, BD Santarsiero, EM Driggers, RC Stevens, ... Nature 389 (6648), 271-275, 1997 | 117 | 1997 |
Ketoreductase polypeptides for the production of azetidinone O Campopiano, E Mundorff, B Borup, R Voladri US Patent 7,883,879, 2011 | 102 | 2011 |
Ketoreductase polypeptides for the reduction of acetophenones J Liang, SJ Jenne, E Mundorff, C Ching, JM Gruber, A Krebber, ... US Patent 8,748,143, 2014 | 99 | 2014 |
Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane J Liang, SJ Jenne, E Mundorff, R Voladri, J Lalonde, G Huisman US Patent 7,977,078, 2011 | 97* | 2011 |
A comparative analysis of the immunological evolution of antibody 28B4 J Yin, EC Mundorff, PL Yang, KU Wendt, D Hanway, RC Stevens, ... Biochemistry 40 (36), 10764-10773, 2001 | 95 | 2001 |
Ketoreductases and uses thereof C Ching, JM Gruber, GW Huisman, E Mundorff, LM Newman US Patent 7,820,421, 2010 | 94 | 2010 |
Ketoreductase enzymes and uses thereof LJ Giver, LM Newman, E Mundorff, GW Huisman, SJ Jenne, J Zhu, ... US Patent 7,879,585, 2011 | 91 | 2011 |
Ketoreductases for the production of (S, E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl) vinyl) phenyl)-3-hroxypropyl) benzoate J Liang, B Borup, V Mitchell, E Mundorff, J Lalonde, GW Huisman US Patent 8,088,610, 2012 | 85 | 2012 |
Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1, 3-oxazolidin-2-one E Mundorff, E De Vries US Patent 8,273,554, 2012 | 83 | 2012 |
Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine C Savile, JM Gruber, E Mundorff, G Huisman, SJ Collier US Patent 8,288,141, 2012 | 68 | 2012 |
Development of a Practical Biocatalytic Process for (R)-2-Methylpentanol OW Gooding, R Voladri, A Bautista, T Hopkins, G Huisman, S Jenne, ... Organic Process Research & Development 14 (1), 119-126, 2010 | 68 | 2010 |
Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement EC Mundorff, MA Hanson, A Varvak, H Ulrich, PG Schultz, RC Stevens Biochemistry 39 (4), 627-632, 2000 | 59 | 2000 |
Ketoreductase polypeptides and uses thereof R Voladri, O Gooding, S Jenne, E Mundorff US Patent 8,288,131, 2012 | 57 | 2012 |