| Oxetanes in drug discovery: structural and synthetic insights G Wuitschik, EM Carreira, B Wagner, H Fischer, I Parrilla, F Schuler, ... Journal of medicinal chemistry 53 (8), 3227-3246, 2010 | 350 | 2010 |
| Oxetanes as promising modules in drug discovery G Wuitschik, M Rogers‐Evans, K Müller, H Fischer, B Wagner, F Schuler, ... Angewandte Chemie International Edition 45 (46), 7736-7739, 2006 | 243 | 2006 |
| Spirocyclic oxetanes: synthesis and properties G Wuitschik, M Rogers-Evans, A Buckl, M Bernasconi, M Marki, T Godel, ... Angewandte Chemie 120 (24), 4588, 2008 | 204 | 2008 |
| Synthesis of azaspirocycles and their evaluation in drug discovery JA Burkhard, B Wagner, H Fischer, F Schuler, K Müller, EM Carreira Angewandte Chemie International Edition 49 (20), 3524-3527, 2010 | 199 | 2010 |
| NADH-quinone oxidoreductase: PSST subunit couples electron transfer from ironsulfur cluster N2 to quinone F Schuler, T Yano, S Di Bernardo, T Yagi, V Yankovskaya, TP Singer, ... Proceedings of the National Academy of Sciences 96 (7), 4149-4153, 1999 | 188 | 1999 |
| Functional coupling of PSST and ND1 subunits in NADH: ubiquinone oxidoreductase established by photoaffinity labeling F Schuler, JE Casida Biochimica et Biophysica Acta (BBA)-Bioenergetics 1506 (1), 79-87, 2001 | 160 | 2001 |
| The transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans from soil into eggs of foraging chicken F Schuler, P Schmid, C Schlatter Chemosphere 34 (4), 711-718, 1997 | 122 | 1997 |
| Combinatorial synthesis of novel and potent inhibitors of NADH: ubiquinone oxidoreductase KC Nicolaou, JA Pfefferkorn, F Schuler, AJ Roecker, GQ Cao, JE Casida Chemistry & biology 7 (12), 979-992, 2000 | 107 | 2000 |
| Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics CW McAleer, CJ Long, D Elbrecht, T Sasserath, LR Bridges, JW Rumsey, ... Science translational medicine 11 (497), eaav1386, 2019 | 97 | 2019 |
| Minimizing DILI risk in drug discoverya screening tool for drug candidates S Schadt, S Simon, S Kustermann, F Boess, C McGinnis, A Brink, ... Toxicology in vitro 30 (1), 429-437, 2015 | 88 | 2015 |
| The insecticide target in the PSST subunit of complex I F Schuler, JE Casida Pest management science 57 (10), 932-940, 2001 | 85 | 2001 |
| Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties HGF Richter, GM Benson, KH Bleicher, D Blum, E Chaput, N Clemann, ... Bioorganic & medicinal chemistry letters 21 (4), 1134-1140, 2011 | 82 | 2011 |
| Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling NA Kratochwil, C Meille, S Fowler, F Klammers, A Ekiciler, B Molitor, ... The AAPS journal 19 (2), 534-550, 2017 | 79 | 2017 |
| Recent developments in using mechanistic cardiac modelling for drug safety evaluation MR Davies, K Wang, GR Mirams, A Caruso, D Noble, A Walz, T Lavé, ... Drug discovery today 21 (6), 924-938, 2016 | 68 | 2016 |
| Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes HGF Richter, GM Benson, D Blum, E Chaput, S Feng, C Gardes, ... Bioorganic & medicinal chemistry letters 21 (1), 191-194, 2011 | 64 | 2011 |
| Photodegradation of polychlorinated dibenzo-p-dioxins and dibenzofurans in cuticular waxes of laurel cherry (Prunus laurocerasus) F Schuler, P Schmid, CH Schlatter Chemosphere 36 (1), 21-34, 1998 | 61 | 1998 |
| Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research K Kroll, M Chabria, K Wang, F Häusermann, F Schuler, L Polonchuk Progress in Biophysics and Molecular Biology 130, 212-222, 2017 | 59 | 2017 |
| A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer K Eyer, F Paech, F Schuler, P Kuhn, R Kissner, S Belli, PS Dittrich, ... Journal of Controlled Release 173, 102-109, 2014 | 52 | 2014 |
| A sensitive in vitro approach to assess the hybridization-dependent toxic potential of high affinity gapmer oligonucleotides A Dieckmann, PH Hagedorn, Y Burki, C Brügmann, M Berrera, M Ebeling, ... Molecular Therapy-Nucleic Acids 10, 45-54, 2018 | 50 | 2018 |
| Differential monocyte actuation in a three‐organ functional innate immune system‐on‐a‐chip T Sasserath, JW Rumsey, CW McAleer, LR Bridges, CJ Long, D Elbrecht, ... Advanced science 7 (13), 2000323, 2020 | 47 | 2020 |
