Dr. Franz Schuler
Dr. Franz Schuler
F. Hoffmann-La Roche Ltd.
Patvirtintas el. paštas
Oxetanes in drug discovery: structural and synthetic insights
G Wuitschik, EM Carreira, B Wagner, H Fischer, I Parrilla, F Schuler, ...
Journal of medicinal chemistry 53 (8), 3227-3246, 2010
Oxetanes as promising modules in drug discovery
G Wuitschik, M Rogers‐Evans, K Müller, H Fischer, B Wagner, F Schuler, ...
Angewandte Chemie International Edition 45 (46), 7736-7739, 2006
Spirocyclic oxetanes: synthesis and properties
G Wuitschik, M Rogers-Evans, A Buckl, M Bernasconi, M Marki, T Godel, ...
Angewandte Chemie 120 (24), 4588, 2008
Synthesis of azaspirocycles and their evaluation in drug discovery
JA Burkhard, B Wagner, H Fischer, F Schuler, K Müller, EM Carreira
Angewandte Chemie International Edition 49 (20), 3524-3527, 2010
NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron–sulfur cluster N2 to quinone
F Schuler, T Yano, S Di Bernardo, T Yagi, V Yankovskaya, TP Singer, ...
Proceedings of the National Academy of Sciences 96 (7), 4149-4153, 1999
Functional coupling of PSST and ND1 subunits in NADH: ubiquinone oxidoreductase established by photoaffinity labeling
F Schuler, JE Casida
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1506 (1), 79-87, 2001
The transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans from soil into eggs of foraging chicken
F Schuler, P Schmid, C Schlatter
Chemosphere 34 (4), 711-718, 1997
Combinatorial synthesis of novel and potent inhibitors of NADH: ubiquinone oxidoreductase
KC Nicolaou, JA Pfefferkorn, F Schuler, AJ Roecker, GQ Cao, JE Casida
Chemistry & biology 7 (12), 979-992, 2000
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics
CW McAleer, CJ Long, D Elbrecht, T Sasserath, LR Bridges, JW Rumsey, ...
Science translational medicine 11 (497), eaav1386, 2019
Minimizing DILI risk in drug discovery—a screening tool for drug candidates
S Schadt, S Simon, S Kustermann, F Boess, C McGinnis, A Brink, ...
Toxicology in vitro 30 (1), 429-437, 2015
The insecticide target in the PSST subunit of complex I
F Schuler, JE Casida
Pest management science 57 (10), 932-940, 2001
Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
HGF Richter, GM Benson, KH Bleicher, D Blum, E Chaput, N Clemann, ...
Bioorganic & medicinal chemistry letters 21 (4), 1134-1140, 2011
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling
NA Kratochwil, C Meille, S Fowler, F Klammers, A Ekiciler, B Molitor, ...
The AAPS journal 19 (2), 534-550, 2017
Recent developments in using mechanistic cardiac modelling for drug safety evaluation
MR Davies, K Wang, GR Mirams, A Caruso, D Noble, A Walz, T Lavé, ...
Drug discovery today 21 (6), 924-938, 2016
Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
HGF Richter, GM Benson, D Blum, E Chaput, S Feng, C Gardes, ...
Bioorganic & medicinal chemistry letters 21 (1), 191-194, 2011
Photodegradation of polychlorinated dibenzo-p-dioxins and dibenzofurans in cuticular waxes of laurel cherry (Prunus laurocerasus)
F Schuler, P Schmid, CH Schlatter
Chemosphere 36 (1), 21-34, 1998
Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research
K Kroll, M Chabria, K Wang, F Häusermann, F Schuler, L Polonchuk
Progress in Biophysics and Molecular Biology 130, 212-222, 2017
A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer
K Eyer, F Paech, F Schuler, P Kuhn, R Kissner, S Belli, PS Dittrich, ...
Journal of Controlled Release 173, 102-109, 2014
A sensitive in vitro approach to assess the hybridization-dependent toxic potential of high affinity gapmer oligonucleotides
A Dieckmann, PH Hagedorn, Y Burki, C Brügmann, M Berrera, M Ebeling, ...
Molecular Therapy-Nucleic Acids 10, 45-54, 2018
Differential monocyte actuation in a three‐organ functional innate immune system‐on‐a‐chip
T Sasserath, JW Rumsey, CW McAleer, LR Bridges, CJ Long, D Elbrecht, ...
Advanced science 7 (13), 2000323, 2020
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Straipsniai 1–20