Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro KH Benam, R Villenave, C Lucchesi, A Varone, C Hubeau, HH Lee, ... Nature methods 13 (2), 151-157, 2016 | 812 | 2016 |
Engineered in vitro disease models KH Benam, S Dauth, B Hassell, A Herland, A Jain, KJ Jang, K Karalis, ... Annual Review of Pathology: Mechanisms of Disease 10 (1), 195-262, 2015 | 628 | 2015 |
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics L Si, H Bai, M Rodas, W Cao, CY Oh, A Jiang, R Moller, D Hoagland, ... Nature biomedical engineering 5 (8), 815-829, 2021 | 332 | 2021 |
Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip KH Benam, R Novak, J Nawroth, M Hirano-Kobayashi, TC Ferrante, ... Cell systems 3 (5), 456-466. e4, 2016 | 307 | 2016 |
Pivotal advance: invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection WL Kok, L Denney, K Benam, S Cole, C Clelland, AJ McMichael, LP Ho Journal of leukocyte biology 91 (3), 357-368, 2012 | 117 | 2012 |
M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza SL Cole, J Dunning, WL Kok, KH Benam, A Benlahrech, E Repapi, ... JCI insight 2 (7), 2017 | 81 | 2017 |
Low shear microfluidic devices and methods of use and manufacturing thereof DE Ingber, KH Benam, R Villenave, GA Hamilton, B Hassell, CD Hinojosa US Patent WO2015138034 A2, 2015 | 78* | 2015 |
Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics L Si, H Bai, M Rodas, W Cao, CY Oh, A Jiang, A Nurani, DY Zhu, G Goyal, ... BioRxiv 13, 2020, 2020 | 76 | 2020 |
Human lung small airway-on-a-chip protocol KH Benam, M Mazur, Y Choe, TC Ferrante, R Novak, DE Ingber 3D Cell Culture: Methods and Protocols, 345-365, 2017 | 71 | 2017 |
Organomimetic devices and methods of use and manufacturing thereof J Fernandez-Alcon, N Wen, R Novak, DE Ingber, GA Hamilton, ... US Patent WO2015138032 A2, 2015 | 63 | 2015 |
Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips KH Benam, R Novak, TC Ferrante, Y Choe, DE Ingber Nature protocols 15 (2), 183-206, 2020 | 43 | 2020 |
How the respiratory epithelium senses and reacts to influenza virus KH Benam, L Denney, LP Ho American Journal of Respiratory Cell and Molecular Biology 60 (3), 259-268, 2019 | 35 | 2019 |
Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics L Si, H Bai, M Rodas, W Cao, CY Oh, A Jiang, R Moller, D Hoagland, ... BioRxiv, 2020.04. 13.039917, 2020 | 32 | 2020 |
Exploring new technologies in biomedical research KH Benam, S Gilchrist, A Kleensang, AB Satz, C Willett, Q Zhang Drug discovery today 24 (6), 1242-1247, 2019 | 31 | 2019 |
Advanced microengineered lung models for translational drug discovery BF Niemeyer, P Zhao, RM Tuder, KH Benam SLAS DISCOVERY: Advancing Life Sciences R&D 23 (8), 777-789, 2018 | 31 | 2018 |
Where we stand: lung organotypic living systems that emulate human-relevant hostenvironment/pathogen interactions RJ Jimenez-Valdes, UI Can, BF Niemeyer, KH Benam Frontiers in Bioengineering and Biotechnology 8, 989, 2020 | 27 | 2020 |
Mucociliary defense: emerging cellular, molecular, and animal models KH Benam, EK Vladar, WJ Janssen, CM Evans Annals of the American Thoracic Society 15 (Supplement 3), S210-S215, 2018 | 27 | 2018 |
Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond KH Benam, M Königshoff, O Eickelberg American Journal of Respiratory and Critical Care Medicine 197 (7), 869-875, 2018 | 26 | 2018 |
Discovery of influenza drug resistance mutations and host therapeutic targets using a human airway chip L Si, R Prantil-Baun, KH Benam, H Bai, M Rodas, M Burt, DE Ingber BioRxiv, 685552, 2019 | 25 | 2019 |
Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Syst 3: 456466. e4 KH Benam, R Novak, J Nawroth, M Hirano-Kobayashi, TC Ferrante, ... | 22 | 2016 |